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68 results for “mitochondria”
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Research ArticleOpen accessEvery word in the titleOptic Neuropathy: Characteristic Pathology for Identifying Drugs with Potential to Cause Mitochondrial ToxicityConnor Dyer, Katlyn Droke, Ugne Zekonyte, Mariana RoscaDeleterious effects on mitochondria are known to be frequently caused by prescription drugs, however, there is no standard and specific testing by pharmaceutical companies on these effects on mitochondria during drug development. The objective of this study is to determine if cases of optic neuropathy are related to drug-induced mitochondrial toxicity in a way that could be used to predict … …American Journal of Pharmacology and Toxicology, Vol. 18, Issue 1 · 19 Jan 2024 · 8,562 accessesView PDFCite
Literature ReviewOpen accessEvery word in the titleMitochondrial Dysfunction Model in the Pathogenesis of Inflammatory Response Development in ObesityAlexander Blagov, Varvara Orekhova et al.Obesity is one of the growing problems of modern society. Although currently used methods of treating obesity, including diet, exercise, and drug therapy, have shown their applicability to more effectively combat obesity, an understanding of the pathogenesis of this disease is required. One of the insufficiently studied factors in the pathogenesis of obesity is the development of mitochondrial dysfunction understanding … …OnLine Journal of Biological Sciences, Vol. 24, Issue 1 · 19 Nov 2023 · 4,933 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleColor Doppler Evaluation of Isovolumetric Relaxation Time and of Signals Arising from Axons of the Median Nerve as a Means to Evaluate Mitochondrial Functionality in the Context of Immunotherapy of Cancer and Chronic Conditions Associated with Mitochondrial DysfunctionStefania Pacini, Marco RuggieroReactive Oxygen Species (ROS) arising from the disruption of mitochondrial respiration act as endogenous mutagens and tumor promoters. When production of ROS exceeds the capacity of DNA repair mechanisms, random mutations and aneuploidy ensue, thousands of genes become unbalanced and genetic/epigenetic chain reactions lead to progressive aneuploidy with only two outcomes: karyotypes so altered that are not viable or karyotypes … …American Journal of Immunology, Vol. 15, Issue 1 · 12 Oct 2019 · 9,690 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleMitochondria are Naturally Micro Robots - A reviewRaffaella Aversa, Relly Victoria V. Petrescu, Antonio Apicella, Florian Ion T. PetrescuThe mitochondrion is a natural robot (cell) with a length of about one micron. Between organisms (plant, animal or human) with its organs and the atomic and molecular components are positioned based cells, which are building all the necessary organs body. Years ago, medical specialists who are studying organ disease have considered that is caused by impaired organ or related … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 4 · 18 Nov 2016 · 8,829 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Effect of Humic Acid on the Content of Trace Element in MitochondriaDaniel Žatko, Janka Vašková, Ladislav Vaško, Peter PatlevičBased on our previous in vitro studies which pointed to the antioxidant properties of humic acids especially concerning radical scavenging activities and ability to maintain the redox system in the cell, an addition of 0.6% humic acid into the diet of farm chicken for 42 days was evaluated. The administration of humic acids have a positive effect on the antioxidant … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 4 · 29 Jan 2015 · 7,984 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCadmium Induced Changes in Metabolic Function of Mitochondrial Isolated from Potato Tissue (Solanum tuberosum L.)Chagra Ali, Djebar Mohammed Réda, Rouabhi Rachid, Berrebbah HouriaProblem statement: Cadmium is highly toxic at low concentrations, but the mechanism of its toxicity is still not understood particularly at the cellular and subcellular level. Approach: In this study we examined the effects of cadmium on the oxidophosphorylation properties of mitochondria isolated from potatoes. Results: Cadmium strongly disturbed the respiratory metabolism of mitochondria isolated especially in the transfer of … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 1 · 31 Aug 2009 · 7,838 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEvidence of Mitochondrial Dysfunction in Autism and Implications for TreatmentDaniel A. Rossignol, J. Jeffrey BradstreetClassical mitochondrial diseases occur in a subset of individuals with autism and are usually caused by genetic anomalies or mitochondrial respiratory pathway deficits. However, in many cases of autism, there is evidence of mitochondrial dysfunction (MtD) without the classic features associated with mitochondrial disease. MtD appears to be more common in autism and presents with less severe signs and symptoms. … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 16,373 accessesView PDFCite
Literature ReviewOpen accessEvery word in the titlePotential Therapies for Mitochondrial Diseases Caused by mtDNA MutationsAnastasia V. Poznyak, Nikolay A. Orekhov, Dmitry Felixovich Beloyartsev et al.Mitochondrial diseases, caused by mutations in mitochondrial DNA (mtDNA), present significant genetic and clinical complexities that challenge accurate diagnosis and treatment. This review examines the critical molecular mechanisms underlying these disorders, particularly the role of heteroplasmy, where mixtures of mutated and normal mtDNA influence disease severity, and the nuclear-mitochondrial DNA interactions that compound diagnostic and therapeutic challenges. The threshold effect, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,735 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSSR Analysis of the Chloroplast and Mitochondrial Genomes of Cultivar Lines and Wild Types of the Sunflower (Helianthus L.)Vladimir Arturovich Khachumov, Alexander Vyacheslavovich Usatov, Kirill Vitalievich Azarin et al.SSR analysis of chloroplast and mitochondrial genomes of cultivar lines and wild species of sunflower (Helianthus L.) were completed. The polymorphism of 18 microsatellite loci of the chloroplast and mitochondrial genomes was investigated. Based on the obtained data was constructed dendrogram showing the genetic diversity of chloroplast and mitochondrial genomes of sunflowers. The studied species were clustered into annual and … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 19 Feb 2020 · 7,675 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDiatrizoate, Iopromide and Iotrolan Enhanced Cytotoxicity of Daunorubicin in Multidrug Resistant K562/adr Cells: Impaired the Mitochondrial and Inhibited the P-Glycoprotein FunctionNitaya Snitwongse Na Ayudhya, Samlee MankhetkornMultidrug resistance was an obstacle in cancer chemotherapy because the cells decreased their intracellular drug accumulation by energy-dependent compounds efflux pumps such as P-glycoprotein (P-gp). This study observed some iodinated radiographic contrast media, diatrizoate, iopromide and iotrolan affected the cellular energetic state and the kinetics of P-gp in drug-sensitive K562 and drug resistant K562/adr cell lines using spectrophotometer and spectrofluorometer. … …American Journal of Applied Sciences, Vol. 6, Issue 3 · 31 Mar 2009 · 7,161 accessesView PDFCite