Author

Stefania Pacini

Silver Spring Sagl, Switzerland

9 articles in our journals

Articles where this person is an author, newest first. People are matched by their name as printed (no ORCID iD is recorded for them), not by name alone; search the name as text to find namesakes too.

Case ReportOpen accessConsumption of an Extremely Biodiverse Probiotic and a Supplement based on Microbial Chondroitin Sulfate is Associated with Very Low Serum Alpha-N-acetylgalactosaminidase (Nagalase) Activity and Decrease of C-reactive Protein ValuesMichael Carter, Stefania Pacini, Marco RuggieroWe describe the case of a 57-years-old male healthy professional who added to his nutritional plan a novel, extremely biodiverse, probiotic and a supplement based on microbial chondroitin sulfate, vitamin D3 and ultrapure phosphatidylcholine to improve his healthy life expectancy. After three months of such a nutritional regimen, serum alpha-N-acetylgalactosaminidase (nagalase) activity was 0.40 that is a value below the … …American Journal of Immunology, Vol. 16, Issue 1 · 22 Apr 2020 · 13,049 accessesView PDF Cite

Research ArticleOpen accessColor Doppler Evaluation of Isovolumetric Relaxation Time and of Signals Arising from Axons of the Median Nerve as a Means to Evaluate Mitochondrial Functionality in the Context of Immunotherapy of Cancer and Chronic Conditions Associated with Mitochondrial DysfunctionStefania Pacini, Marco RuggieroReactive Oxygen Species (ROS) arising from the disruption of mitochondrial respiration act as endogenous mutagens and tumor promoters. When production of ROS exceeds the capacity of DNA repair mechanisms, random mutations and aneuploidy ensue, thousands of genes become unbalanced and genetic/epigenetic chain reactions lead to progressive aneuploidy with only two outcomes: karyotypes so altered that are not viable or karyotypes … …American Journal of Immunology, Vol. 15, Issue 1 · 12 Oct 2019 · 9,690 accessesView PDF Cite

Research ArticleOpen accessUse of an Extremely Biodiverse Probiotic and a Supplement Based on Microbial Chondroitin Sulfate is Associated with a Significant Decrease of Serum Free Kappa Light Chains as well as a Trend Toward Normalization of Kappa/Lambda Ratio and of Plasma Cell Bone Marrow Infiltration in a Case of Multiple MyelomaNicola Antonucci, Stefania Pacini, Marco RuggieroWe describe the case of a 71-year-old woman with multiple myeloma associated with severe chronic renal insufficiency who, since October 2018, assumed a novel, extremely biodiverse, probiotic and a supplement based on microbial chondroitin sulfate, vitamin D3 and ultrapure phosphatidylcholine; such a nutritional regimen was associated with a dramatic decrease of serum free Kappa light chains (from 2,190 to a … …American Journal of Immunology, Vol. 15, Issue 1 · 18 Jun 2019 · 27,910 accessesView PDF Cite

Research ArticleOpen accessTailoring the Ruggiero-Klinghardt Protocol to Immunotherapy of AutismNicola Antonucci, Dietrich Klinghardt, Stefania Pacini, Marco RuggieroHere, we describe the adaptation to the field of autism of an original procedure denominated the "Ruggiero-Klinghardt Protocol" (RK Protocol), a procedure that represents a paradigm change with significant implications for chronic conditions where immunotherapy may prove effective; that is from silent infections to neurodegenerative diseases, autism and cancer. In the context of autism, the modified RK Protocol that we … …American Journal of Immunology, Vol. 14, Issue 1 · 25 Apr 2019 · 11,204 accessesView PDF Cite

Case ReportOpen accessClinical Case Report of a Novel Immunotherapeutic Approach to Autism Spectrum Disorders based on an emulsion of Chondroitin Sulfate, Vitamin D3 and Oleic AcidNicola Antonucci, Stefania Pacini, Marco RuggieroIn this clinical case report we describe the effects associated with the administration of a supplement constituted by chondroitin sulfate, vitamin D3 and oleic acid (Rerum®) on the symptoms of Autism Spectrum Disorders (ASD). 44 patients (11 females and 33 males) were administered this supplement for a period of two months and variations of symptomatology were evaluated by the Clinical … …American Journal of Immunology, Vol. 13, Issue 3 · 10 Aug 2017 · 19,224 accessesView PDF Cite

Research ArticleOpen accessDescription of a Novel Probiotic Concept: Implications for the Modulation of the Immune SystemStefania Pacini, Marco RuggieroIt is estimated that the first processed food products consumed by humans pertained to the category of fermented foods and beverages such as beer, wine, sauerkraut, fermented sausage as well as fermented milk derivatives such as yogurt and kefir. Thus, fermented foods are endowed with undisputed healthy properties due to the presence of probiotic microbes that not only help supporting … …American Journal of Immunology, Vol. 13, Issue 2 · 28 Jan 2017 · 9,237 accessesView PDF Cite

Research ArticleOpen accessEffects of Gc-Macrophage Activating Factor in Human Neurons; Implications for Treatment of Chronic Fatigue SyndromeRodney Smith, Lynda Thyer, Emma Ward et al.Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease of multifactorial aetiology characterized by immune system dysfunction, widespread inflammation, multisystemic neuropathology and persistent pain. Given the central role of the immune system in the pathogenesis of the syndrome, we studied the effects of a potent modulator of the immune system in in vitro and in vivo models that could help … …American Journal of Immunology, Vol. 9, Issue 4 · 6 Nov 2013 · 10,982 accessesView PDF Cite

Research ArticleOpen accessTherapeutic Effects of Highly Purified De-Glycosylated Gcmaf in the Immunotherapy of Patients with Chronic DiseasesLynda Thyer, Emma Ward, Rodney Smith et al.The de-Glycosylated vitamin D binding protein is a powerful Macrophage Activating Factor (GcMAF) that shows multiple biological effects that could be exploited in the immunotherapy of tumours, viral infections and autism. Here we report the observation of a series of clinical cases describing the results obtained administering highly purified GcMAF to patients with diverse types of chronic diseases. These are … …American Journal of Immunology, Vol. 9, Issue 3 · 20 Aug 2013 · 11,858 accessesView PDF Cite

Research ArticleOpen accessRole of Angiotensin-Converting Enzyme and Vitamin D Receptor Gene Polymorphisms in Cancer Anorexia-Cachexia SyndromeAriele Fabris, Paolo Biagioni, Tiziana Punzi et al.The ubiquitin-proteasome pathway is a crucial connection between aberrant immune system activation, systemic inflammation and Cancer Anorexia-Cachexia Syndrome (CACS), a syndrome that culminates in hyper-activation of the ubiquitin-proteasome pathway. Angiotensin directly up-regulates this pathway, while vitamin D down-regulates it indirectly through the insulin-like growth factor-1 pathway. We investigated the genetic predisposition towards CACS in a cancer population, examining Insertion/Deletion (I/D) … …American Journal of Immunology, Vol. 8, Issue 3 · 2 Aug 2012 · 9,560 accessesView PDF Cite