Author

Marco Ruggiero

National Coalition of Independent Scholars, Battleboro, VT, United States

20 articles in our journals

Articles where this person is an author, newest first. People are matched by their name as printed (no ORCID iD is recorded for them), not by name alone; search the name as text to find namesakes too.

Research ArticleOpen accessGenetic Analysis of Bifidobacteriaceae in a Fermented Milk and Colostrum Product in Relation to Immune FunctionMarco RuggieroThis study investigates the microbial composition of a commercially available Swiss fermented milk and colostrum product with a history of use in chronic condition management since 2014. The analysis, performed using the Axiom Microbiome Array, identified a high number of targets corresponding to microbial species classified as probiotics belonging to the Bifidobacteriaceae family. The array provided 28 unique targets, each … …American Journal of Immunology, Vol. 19, Issue 1 · 2 Aug 2024 · 9,049 accessesView PDF Cite

Literature ReviewOpen accessOn the Natural Intelligence and Consciousness of the Immune System and its Relationship with the BrainMarco Ruggiero, Akira HiratsukaIn this article, we consider the relationship between the brain and the immune system in the context of the Orchestrated Objective Reduction (Orch OR) theory of consciousness. Orch OR is a theory that postulates that consciousness arises from quantum computations occurring inside microtubules. The immune system is capable of acquiring, learning, and remembering information, thus showing all the attributes of … …American Journal of Immunology, Vol. 19, Issue 1 · 17 Apr 2024 · 11,431 accessesView PDF Cite

Research ArticleOpen accessEffects of a Topical Composition of GABA and Microbial Chondroitin Sulfate on Mental Calmness and Brain FunctionMarco RuggieroThis article describes a novel topical composition constituted by Gamma-Aminobutyric Acid (GABA) and microbial chondroitin sulfate. This composition, formulated by the author and manufactured in a certified facility in the United States of America, exhibits potential for non-invasive intervention in anxiety management, sleep quality enhancement and promotion of brain-related functions like meditation and nonlocal consciousness. The core component comprises GABA, … …American Journal of Immunology, Vol. 19, Issue 1 · 8 Mar 2024 · 11,673 accessesView PDF Cite

Research ArticleOpen accessRelease of Endogenous Chondroitin Sulfate and Heparin as Consequence of Dysregulated Proteolysis in COVID-19Marco RuggieroInfection by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), the pathogen responsible for COVID-19, is associated with immune-mediated responses that lead to dysregulated activation of proteolytic enzymes; these contribute to damage to the endothelium, thrombosis, hypercoagulability and other hematologic complications that include thrombotic thrombocytopenia, a complication of severe COVID-19 as well as a potentially fatal adverse effect of COVID-19 vaccination. … …American Journal of Immunology, Vol. 17, Issue 1 · 29 Dec 2021 · 7,688 accessesView PDF Cite

Research ArticleOpen accessExperimental Evidence for the Role of Natural Radioactivity in Influencing Viability of Commensal MicroorganismsMarco RuggieroTo investigate the feasibility of culturing edible microbes, classified as probiotics for human consumption, in commercially available, naturally radioactive, mineral water; to compare their viability with that of the same microbes cultured in deuterium-depleted water. A diversified array of probiotics was cultured in two different naturally radioactive mineral waters, or in deuterium-depleted water in order to assess the effects of … …American Journal of Immunology, Vol. 17, Issue 1 · 26 May 2021 · 8,741 accessesView PDF Cite

Case ReportOpen accessEffects on the Immune System of a Three-Month Consumption of an Extremely Diverse Probiotic Yogurt: Decrease of Serum Alpha-N-Acetylgalactosaminidase Activity, Detoxification and Gut Microbiota NormalizationJerry Blythe, Marco RuggieroIn this study, we describe the changes associated with the consumption of an extremely biodiverse probiotic yogurt in a 55-year-old female from South Vietnam. In August 2019, the subject voluntarily embarked on a three-month nutritional experience and decided to share her results with the goal of advancing scientific knowledge in the field of nutritional health. Consumption of this biodiverse probiotic … …American Journal of Immunology, Vol. 16, Issue 1 · 22 Oct 2020 · 9,697 accessesView PDF Cite

Case ReportOpen accessConsumption of an Extremely Biodiverse Probiotic and a Supplement based on Microbial Chondroitin Sulfate is Associated with Very Low Serum Alpha-N-acetylgalactosaminidase (Nagalase) Activity and Decrease of C-reactive Protein ValuesMichael Carter, Stefania Pacini, Marco RuggieroWe describe the case of a 57-years-old male healthy professional who added to his nutritional plan a novel, extremely biodiverse, probiotic and a supplement based on microbial chondroitin sulfate, vitamin D3 and ultrapure phosphatidylcholine to improve his healthy life expectancy. After three months of such a nutritional regimen, serum alpha-N-acetylgalactosaminidase (nagalase) activity was 0.40 that is a value below the … …American Journal of Immunology, Vol. 16, Issue 1 · 22 Apr 2020 · 13,049 accessesView PDF Cite

Research ArticleOpen accessColor Doppler Evaluation of Isovolumetric Relaxation Time and of Signals Arising from Axons of the Median Nerve as a Means to Evaluate Mitochondrial Functionality in the Context of Immunotherapy of Cancer and Chronic Conditions Associated with Mitochondrial DysfunctionStefania Pacini, Marco RuggieroReactive Oxygen Species (ROS) arising from the disruption of mitochondrial respiration act as endogenous mutagens and tumor promoters. When production of ROS exceeds the capacity of DNA repair mechanisms, random mutations and aneuploidy ensue, thousands of genes become unbalanced and genetic/epigenetic chain reactions lead to progressive aneuploidy with only two outcomes: karyotypes so altered that are not viable or karyotypes … …American Journal of Immunology, Vol. 15, Issue 1 · 12 Oct 2019 · 9,690 accessesView PDF Cite

Research ArticleOpen accessUse of an Extremely Biodiverse Probiotic and a Supplement Based on Microbial Chondroitin Sulfate is Associated with a Significant Decrease of Serum Free Kappa Light Chains as well as a Trend Toward Normalization of Kappa/Lambda Ratio and of Plasma Cell Bone Marrow Infiltration in a Case of Multiple MyelomaNicola Antonucci, Stefania Pacini, Marco RuggieroWe describe the case of a 71-year-old woman with multiple myeloma associated with severe chronic renal insufficiency who, since October 2018, assumed a novel, extremely biodiverse, probiotic and a supplement based on microbial chondroitin sulfate, vitamin D3 and ultrapure phosphatidylcholine; such a nutritional regimen was associated with a dramatic decrease of serum free Kappa light chains (from 2,190 to a … …American Journal of Immunology, Vol. 15, Issue 1 · 18 Jun 2019 · 27,910 accessesView PDF Cite

Research ArticleOpen accessTailoring the Ruggiero-Klinghardt Protocol to Immunotherapy of AutismNicola Antonucci, Dietrich Klinghardt, Stefania Pacini, Marco RuggieroHere, we describe the adaptation to the field of autism of an original procedure denominated the "Ruggiero-Klinghardt Protocol" (RK Protocol), a procedure that represents a paradigm change with significant implications for chronic conditions where immunotherapy may prove effective; that is from silent infections to neurodegenerative diseases, autism and cancer. In the context of autism, the modified RK Protocol that we … …American Journal of Immunology, Vol. 14, Issue 1 · 25 Apr 2019 · 11,204 accessesView PDF Cite