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37 results for “Alexander Orekhov”
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Literature ReviewOpen accessIn the author namesUnraveling NETosis: From Immune Mechanisms to Therapeutic InnovationsAnastasia V. Poznyak, Alexey V. Churov, Gulalek Amanmyradovna Babayeva et al.Neutrophil Extracellular Traps (NETs) are integral to immune responses, serving both protective and pathological roles in inflammatory diseases. Despite increasing recognition of NETs, significant gaps remain in understanding the nuanced mechanisms of NETosis and its implications for health and disease. This review systematically explores NETosis—the formation of NETs—by elucidating the molecular signaling pathways and cellular mechanisms involved. We highlight the … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 21 Feb 2026 · 1,685 accessesView PDFCite
Literature ReviewOpen accessIn the author namesSigns of Predisposition to Atherosclerosis in Fetal DevelopmentAnastasia Vladimirovna Poznyak, Igor Alexandrovich Sobenin, Elizaveta M. Pleshko et al.Atherosclerotic Cardiovascular Disease (ASCVD) remains a significant global health concern, contributing to a substantial number of deaths worldwide. The etiology of this condition is multifaceted, influenced by a plethora of genetic and environmental determinants. Notably, certain risk factors and predictive markers associated with ASCVD may already present or emerge during the prenatal or neonatal period. Early recognition of these markers … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,307 accessesView PDFCite
Literature ReviewOpen accessIn the author namesCorrelation of Atherosclerosis and Osteoarthritis, the Role of Inflammation in the Pathogenesis of Osteoarthritis and AtherosclerosisAnastasia V. Poznyak, Nikolay A. Orekhov, Aleksandra Sergeevna Utkina et al.Cardiovascular Diseases (CVD) rank among the leading causes of death globally, accounting for a substantial proportion of mortality rates and affecting millions of individuals. Risk factors such as ageing, obesity, diabetes and a sedentary lifestyle contribute significantly to the prevalence of CVD. Osteoarthritis (OA), on the other hand, is one of the most common joint disorders, affecting a large segment … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,777 accessesView PDFCite
Literature ReviewOpen accessIn the author namesPotential Therapies for Mitochondrial Diseases Caused by mtDNA MutationsAnastasia V. Poznyak, Nikolay A. Orekhov, Dmitry Felixovich Beloyartsev et al.Mitochondrial diseases, caused by mutations in mitochondrial DNA (mtDNA), present significant genetic and clinical complexities that challenge accurate diagnosis and treatment. This review examines the critical molecular mechanisms underlying these disorders, particularly the role of heteroplasmy, where mixtures of mutated and normal mtDNA influence disease severity, and the nuclear-mitochondrial DNA interactions that compound diagnostic and therapeutic challenges. The threshold effect, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,750 accessesView PDFCite
Review ArticleOpen accessIn the author namesTheory and Strategies of Atherosclerotic Renal Artery Stenosis TreatmentAnastasia V. Poznyak, Nikolay A. Orekhov, Gulalek Amanmyradovna Babayeva et al.Atherosclerosis is a disease that affects large arteries and contributes to the development of cardiovascular disease and adverse events. The main characteristic of this disease is the formation of plaques that narrow the lumen of the vessel. However, atherosclerosis is not the only cause of vasoconstriction. For example, various causes may be involved in renal artery stenosis, such as vasculitis … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 4 Jan 2026 · 1,862 accessesView PDFCite
Review ArticleOpen accessIn the author namesObesity as a Predisposing Factor for AtherosclerosisAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina et al.Obesity stands as a pressing global health concern, associated with a myriad of threats to human well-being and longevity. Within the scope of this review, we zero in on how obesity impacts the onset of atherosclerosis, given its well-established link as a risk factor in its development. The progression of atherosclerosis is notably hastened by obesity, driven by a host … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 23 Jul 2025 · 2,742 accessesView PDFCite
Literature ReviewOpen accessIn the author namesUnraveling Sterile Inflammation in Atherosclerosis: Mechanisms, Implications and Therapeutic StrategiesAnastasia Vladimirovna Poznyak, Vasily Nikolaevich Sukhorukov, Anton Yuvenalievich Postnov et al.Atherosclerosis, a leading factor in the development of cardiovascular diseases, is a complex and multifaceted condition with inflammation emerging as a pivotal determinant of its pathogenesis. This review comprehensively investigates the role of sterile inflammation in atherosclerosis and deliberates on potential therapeutic interventions targeting this underlying mechanism. Despite advancements in the understanding of atherosclerosis, diagnosing, preventing, and choosing effective treatment … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 4 Mar 2025 · 3,973 accessesView PDFCite
Review ArticleOpen accessIn the author namesThe Effect of Main Heat Shock Proteins on AtherosclerosisAnastasia Vladimirovna Poznyak, Alexey V. Churov et al.Atherosclerosis is a multifaceted disease characterized by complex pathogenesis involving diverse mechanisms. In recent years, the autoimmune nature of atherosclerosis has gained significant attention, emphasizing the indispensable role of the immune system in its initiation and progression. Heat Shock Proteins (HSPs) are vital for cellular functionality, facilitating cellular adaptation to environmental changes and survival under adverse conditions. Notably, various HSP … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 3 Oct 2024 · 4,361 accessesView PDFCite
Literature ReviewOpen accessIn the author namesUnveiling the Complex Relationship between Polycystic Ovary Syndrome and Cardiovascular Risk Factors: A Comprehensive ReviewAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina et al.Polycystic ovary syndrome remains a relatively unexplored endocrine disorder with significant implications for female health. Despite its prevalence and known associations with various metabolic disorders, the specific link between polycystic ovary syndrome and cardiovascular risk factors, particularly atherosclerosis, remains inadequately understood. This review aims to address the existing research gap by investigating the connection between polycystic ovary syndrome and cardiovascular … …OnLine Journal of Biological Sciences, Vol. 25, Issue 1 · 2 Oct 2024 · 4,614 accessesView PDFCite
Review ArticleOpen accessIn the author namesCirculating Immune Complexes as an Important Link between Inflammation and Lipid Alterations in AtherosclerosisAnastasia Vladimirovna Poznyak, Nikolay Alexandrovich Orekhov, Vasily Nikolaevich Sukhorukov et al.This review article rigorously investigates the emerging facets of atherosclerosis pathogenesis through an exhaustive examination of the existing data on the intricate interplay between lipid metabolism disorders and inflammation. A primary objective of this study is to thoroughly explore the role of Circulating Immune Complexes (CIC) as a pivotal indicator of this multifaceted interaction. The focus of this review centers … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 14 Aug 2024 · 3,932 accessesView PDFCite