Author

Vasily Nikolaevich Sukhorukov

Institute of Experimental Cardiology, National Medical Research Center of Cardiology, Moscow, Russia

24 articles in our journals

Articles where this person is an author, newest first. People are matched by their name as printed (no ORCID iD is recorded for them), not by name alone; search the name as text to find namesakes too.

Review ArticleOpen accessResveratrol for Atherosclerosis: Potential MechanismsAnastasia Vladimirovna Poznyak, Sergey Kozlov, Gulalek A Babayeva et al.Cardiovascular disease is a big problem around the world. At the heart of most serious cardiovascular diseases is such a pathology as atherosclerosis. Atherosclerosis is a complex set of interactions between inflammation, oxidative stress, lipid disorders, and other molecular, genetic, and lifestyle factors. It is this complexity and multicomponent nature of atherogenesis that make the treatment of atherosclerosis a non-trivial … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 11 Aug 2026 · 605 accessesView PDF Cite

Literature ReviewOpen accessIntracranial Atherosclerotic Disease: Treatment Potential and Diagnostic OpportunitiesAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Anton Yuvenalievich Postnov et al.Atherosclerosis, characterized by the accumulation of atherosclerotic plaques within large arteries, substantially increases the risk of cardiovascular events, including ischemic stroke. Intracranial atherosclerotic disease (ICAD) represents a particularly significant clinical threat given its strong association with ischemic stroke across multiple intracranial arterial territories. This review provides a comprehensive analysis of the pathogenesis, diagnosis, and management of intracranial atherosclerosis. Special attention … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 5 May 2026 · 1,093 accessesView PDF Cite

Review ArticleOpen accessRole of HDL in Atherogenesis: Cholesterol and AtheroprotectionAnastasia Vladimirovna Poznyak, Vasily Nikolaevich Sukhorukov, Victor Yurievich Glanz et al.Atherosclerosis is a major global health burden, responsible for a significant proportion of cardiovascular morbidity and mortality worldwide. Its high prevalence and severe clinical consequences have made it a subject of extensive research. Despite considerable advances, the complexity of its pathogenesis continues to hinder the development of effective preventive strategies and therapeutic interventions. Current evidence implicates chronic inflammation, dysregulated lipid … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 3 Apr 2026 · 1,476 accessesView PDF Cite

Literature ReviewOpen accessSigns of Predisposition to Atherosclerosis in Fetal DevelopmentAnastasia Vladimirovna Poznyak, Igor Alexandrovich Sobenin, Elizaveta M. Pleshko et al.Atherosclerotic Cardiovascular Disease (ASCVD) remains a significant global health concern, contributing to a substantial number of deaths worldwide. The etiology of this condition is multifaceted, influenced by a plethora of genetic and environmental determinants. Notably, certain risk factors and predictive markers associated with ASCVD may already present or emerge during the prenatal or neonatal period. Early recognition of these markers … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,302 accessesView PDF Cite

Review ArticleOpen accessObesity as a Predisposing Factor for AtherosclerosisAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina et al.Obesity stands as a pressing global health concern, associated with a myriad of threats to human well-being and longevity. Within the scope of this review, we zero in on how obesity impacts the onset of atherosclerosis, given its well-established link as a risk factor in its development. The progression of atherosclerosis is notably hastened by obesity, driven by a host … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 23 Jul 2025 · 2,737 accessesView PDF Cite

Literature ReviewOpen accessUnraveling Sterile Inflammation in Atherosclerosis: Mechanisms, Implications and Therapeutic StrategiesAnastasia Vladimirovna Poznyak, Vasily Nikolaevich Sukhorukov, Anton Yuvenalievich Postnov et al.Atherosclerosis, a leading factor in the development of cardiovascular diseases, is a complex and multifaceted condition with inflammation emerging as a pivotal determinant of its pathogenesis. This review comprehensively investigates the role of sterile inflammation in atherosclerosis and deliberates on potential therapeutic interventions targeting this underlying mechanism. Despite advancements in the understanding of atherosclerosis, diagnosing, preventing, and choosing effective treatment … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 4 Mar 2025 · 3,965 accessesView PDF Cite

Review ArticleOpen accessThe Effect of Main Heat Shock Proteins on AtherosclerosisAnastasia Vladimirovna Poznyak, Alexey V. Churov et al.Atherosclerosis is a multifaceted disease characterized by complex pathogenesis involving diverse mechanisms. In recent years, the autoimmune nature of atherosclerosis has gained significant attention, emphasizing the indispensable role of the immune system in its initiation and progression. Heat Shock Proteins (HSPs) are vital for cellular functionality, facilitating cellular adaptation to environmental changes and survival under adverse conditions. Notably, various HSP … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 3 Oct 2024 · 4,354 accessesView PDF Cite

Literature ReviewOpen accessUnveiling the Complex Relationship between Polycystic Ovary Syndrome and Cardiovascular Risk Factors: A Comprehensive ReviewAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina et al.Polycystic ovary syndrome remains a relatively unexplored endocrine disorder with significant implications for female health. Despite its prevalence and known associations with various metabolic disorders, the specific link between polycystic ovary syndrome and cardiovascular risk factors, particularly atherosclerosis, remains inadequately understood. This review aims to address the existing research gap by investigating the connection between polycystic ovary syndrome and cardiovascular … …OnLine Journal of Biological Sciences, Vol. 25, Issue 1 · 2 Oct 2024 · 4,607 accessesView PDF Cite

Review ArticleOpen accessCirculating Immune Complexes as an Important Link between Inflammation and Lipid Alterations in AtherosclerosisAnastasia Vladimirovna Poznyak, Nikolay Alexandrovich Orekhov, Vasily Nikolaevich Sukhorukov et al.This review article rigorously investigates the emerging facets of atherosclerosis pathogenesis through an exhaustive examination of the existing data on the intricate interplay between lipid metabolism disorders and inflammation. A primary objective of this study is to thoroughly explore the role of Circulating Immune Complexes (CIC) as a pivotal indicator of this multifaceted interaction. The focus of this review centers … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 14 Aug 2024 · 3,926 accessesView PDF Cite

Review ArticleOpen accessVLDL in Atherosclerosis: Variety of Mechanistic ImplicationsAnastasia Vladimirovna Poznyak, Victor Yurievich Glanz, Vasily Nikolaevich Sukhorukov et al.Very-Low-Density Lipoprotein (VLDL) particles play a pivotal role as precursors for Intermediate-Density Lipoprotein (IDL) and eventually transform into Low-Density Lipoprotein (LDL). These particles have been categorized based on size and particle charge. Various types of VLDL impact diverse physiological processes in the human body. The accumulation of VLDL, along with other triglyceride-rich lipoproteins, significantly contributes to the development of atherosclerotic … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 29 Jul 2024 · 4,308 accessesView PDF Cite