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Research ArticleOpen accessPhrase in the titleTolemerase Reverse Transcriptase Gene Expression as a Tumor Marker for Hepatocellular CarcinomaM. Magdi Atta, Naglaa Al-Toukhy, Omnia Al-Said et al.Problem statement: Hepatocellular carcinoma will emerge as a major form of malignancy in the coming decades. The continuing high incidence of hepatocellular carcinoma, suggests that this disease will continue to represent a global health problem far into the future. Different genes encode for the various components of the human telomerase complex. These components include the human Telomerase RNA Component (hTERC) … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 2 · 3 Aug 2011 · 7,905 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleCorrelation of Some Tumor Markers Between Serum and Saliva of Patients with Breast CancerHuthaifa Tarawneh, Omar AtroozBreast cancer, which affects 36% of all female oncological patients, is the most frequent cancer in the world among women. Since routine laboratory evaluation of serum can be stressful for patients, it is critical to comprehend the features and limitations of salivary test methods in order to achieve an accurate diagnosis of breast cancer. The purpose of the study is … …OnLine Journal of Biological Sciences, Vol. 25, Issue 1 · 12 Oct 2024 · 4,901 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSoluble Tumor Necrosis Factor Receptor Type I and Dranulysin as Immunological Markers in Congestive Heart FailureSimone de Lima e Silva Deo, Maria Do Carmo Valente De Crasto, Alda Maria Da-Cruz et al.Previous studies have shown that circulating levels of cytokines are increased in patients with congestive heart failure (CHF), resulting in myocardial depression. In this work, we have determined serum levels of TNF-α and IFN-γ by ELISA, detected sTNFR-I by dot ELISA, as well as TNFα, IL-6, IL-10 and granulysin mRNA in unstimulated peripheral blood mononuclear cells (PBMC) by RT-PCR in … …American Journal of Immunology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,773 accessesView PDFCite
Review ArticleOpen accessIn the keywordsRoles of DLK1 in Liver Development and OncogenesisIsabella Kurnia Liem, Sibiri Indriyani, Msy Rulan Adnindya, Ahmad Azmi NasutionHepato Cellular Carcinoma (HCC) has an increased mortality rate in the last decade. Protein expression in HCC has similarities to the liver cells during the development process. One of the proteins expressions is Delta-Like 1 homolog (DLK1) that was found during liver development and oncogenesis. This permits the opportunity to study pathophysiology and signaling pathway of DLK1 and to find … …OnLine Journal of Biological Sciences, Vol. 17, Issue 4 · 23 Oct 2017 · 8,053 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCorrelation of Some Biochemical Parameters between Serum and Saliva of Patients with Breast CancerOmar Atrooz, Huthaifa TarawnehRegular breast cancer laboratory examination of serum is aburden on patients, therefore understanding salivary test methods' featuresand limits is important for diagnosis. The study aims to evaluate thebiochemical parameters in the serum and saliva of breast cancer and controlindividuals. Furthermore, to investigate the correlation between two biofluidlevels in both groups. This cross-sectional study recruited Jordanian femalesincluding 40 breast cancer patients … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 20 May 2025 · 4,487 accessesView PDFCite
Research ArticleOpen accessIn the keywordsImpact of Vitamin B17 Against Growth of Colitis Bearing Mice Induced Variations in Colon Structure, AFP, CEA and PCNA ImmunoreactivityGihan Hosny Abd Elsamie, Sabah Gaber El-Banna, Ehab Tousson et al.Colitis alludes to inflammation of the internal coating of the colon that accompanied clinically through abdominal pains, diarrhea, weight loss, nausea. Current study aimed to study the impact of vitamin B17 against growth of colitis bearing mice induced variations in colon structure, AFP, CEA and PCNA immune reactivity. Forty female Swiss albino mice separated into 4 groups (Control, vitamin B17, … …OnLine Journal of Biological Sciences, Vol. 21, Issue 3 · 23 Aug 2021 · 6,397 accessesView PDFCite
Research ArticleOpen accessIn the abstractDecoding Lung Cancer: PLAU as a Critical Driver and Diagnostic MarkerStanley Cho, Min Gyeong KimLung cancer remains a leading cause of cancer-related mortality, and understanding its underlying molecular mechanisms is critical for developing targeted therapies. We developed a novel tool called the Transcriptome-TCGA Integration (TTI), which combines in vitro transcriptome data with clinical datasets from the Cancer Genome Atlas (TCGA). TTI allows for the identification of key genes and pathways involved in lung cancer, … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,424 accessesView PDFCite
Research NotesOpen accessIn the abstractHistopathological Characterization and Expression of Vitamin D Receptor in the Prostate of Healthy Dogs and Dogs with Prostatic CarcinomaAkiko Ikeda, Masanori Kobayashi, Tatsuya Hori et al.Vitamin D Receptor (VDR) expression is implicated in human Prostatic Carcinoma (PC), but its role in canine PC is unclear. To investigate how VDR expression is affected by age and castration in healthy dogs and how it changes with PC, we evaluated prostates from 8-month-old (n = 5) or 6-year-old (n = 8) intact males, 1-8-year-old healthy castrated males (n … …American Journal of Animal and Veterinary Sciences, Vol. 18, Issue 1 · 24 Feb 2023 · 5,291 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvestigation of Inflammatory and Oxidative Stress Biomarkers in Multi Vessels Minimally Invasive Coronary Artery Bypass Graft Surgery Versus Off-Pump Coronary Artery Bypass GraftMohammed Farouk Abdel-Hafez, Ahmed El-Minshawy, Ahmed M. Taha et al.Traditional Coronary Artery Bypass Graft (CABG) is currently among of the chief methods in dealing with patients suffering from atherosclerotic coronary heart disease. The current study aimed to measure and compare the levels of proinflammatory cytokines and oxidative stress marker in patients who underwent multivessels Minimally Invasive Coronary Artery Bypass Graft Surgery (MICS– CABG) versus off-pump Coronary Artery Bypass Grafting … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 3 · 29 Sep 2021 · 6,170 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Metformin Treatment on Inflammatory Factors and Gut Microbial Diversity in Patients with Type II Diabetes MellitusLei Tong, Jingjing Zhang, Li Xiao Yue et al.With the persistent rise in the prevalence of Type 2 Diabetes Mellitus (T2DM), traditional treatment evaluations have primarily focused on glycemic control, often overlooking the multidimensional effects of medications. As a first-line therapeutic agent, the anti-inflammatory effects and gut microbiota regulation mechanisms of metformin remain incompletely elucidated. This prospective cohort study established a metformin treatment group and a T2DM control … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 20 Jul 2026 · 774 accessesView PDFCite