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62 articles for “therapeutic agent”
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Research ArticleOpen accessIn the keywordsAntimicrobial Activity of Ficus benghalensis and Ficus racemosa roots L.Krishna Murti, Upendra KumarProblems statement: To evaluate the antimicrobial activity of aqueous and ethanolic extracts of Ficus benghalensis and Ficus racemosa against three bacterial strains that is Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumonia. Approach: The different concentrations viz. 25, 50 and 75 mg mL-1 of aqueous as well as ethanolic extract solutions of roots of Ficus benghalensis and Ficus racemosa were tested … …Current Research in Microbiology, Vol. 2, Issue 1 · 25 Jan 2012 · 14,486 accessesView PDFCite
Review ArticleOpen accessIn the abstractJAK Inhibitors for Rheumatoid Arthritis: Assessing Efficacy and Safety in TreatmentAnastasia V. Poznyak, Varvara A Orekhova, Natalia Vladimirovna Elizova et al.Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, progressive joint destruction, and systemic complications. Dysregulated cytokine signaling through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway plays a central role in RA pathogenesis, making JAK inhibitors an important therapeutic option. Tofacitinib, baricitinib, and upadacitinib are oral targeted synthetic disease-modifying antirheumatic drugs that interfere with … …OnLine Journal of Biological Sciences, Vol. 26, Issue 4 · 8 Oct 2026 · 412 accessesView PDFCite
Review ArticleOpen accessIn the abstractMultidrug Resistant Microorganisms (MDR) and Biofilm Producers: A Challenge for Hospital Infectious ControlDaniel Lucio, Elizabeth Proaño, Alberto Bustillos et al.Antimicrobial Resistance (AMR) now represents a major threat to contemporary health care, especially in hospitals, where repeated antimicrobial exposure selects for and facilitates the dissemination of Multidrug-Resistant (MDR) microorganisms. Biofilm growth adds another layer of persistence by increasing microbial tolerance, supporting long-term colonization of medical devices, and worsening clinical and economic outcomes. This narrative review synthesizes evidence on MDR biofilm-forming … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 12 Sep 2026 · 774 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Metformin Treatment on Inflammatory Factors and Gut Microbial Diversity in Patients with Type II Diabetes MellitusLei Tong, Jingjing Zhang, Li Xiao Yue et al.With the persistent rise in the prevalence of Type 2 Diabetes Mellitus (T2DM), traditional treatment evaluations have primarily focused on glycemic control, often overlooking the multidimensional effects of medications. As a first-line therapeutic agent, the anti-inflammatory effects and gut microbiota regulation mechanisms of metformin remain incompletely elucidated. This prospective cohort study established a metformin treatment group and a T2DM control … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 20 Jul 2026 · 774 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudy of Ageratum conyzoides L. (Asteraceae) Phytochemical Composition as Quorum-sensing Inhibitors to Combat Antibiotic-resistant Bacterial InfectionsEli Compaoré, Lassané Ouedraogo, Ablassé Rouamba et al.The rise of antibiotic-resistant bacterial infections has intensified the search for plant-derived quorum-sensing (QS) inhibitors as alternative therapeutic strategies. Ageratum conyzoides L. has a long history of traditional use as an antimicrobial agent against multidrug-resistant pathogens, yet the phytochemical basis of its QS-inhibitory activity remains incompletely characterized. This study aimed to investigate the phytochemical composition of A. conyzoides and evaluate … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 3 Apr 2026 · 1,772 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntiproliferative Potential of Pomegranate Peel Extract in MDA-MB Breast Cancer Cell LinesManal Asif Hamdulay, Fatema Yusuf Singaporewala, Grisilda Vidya Bernhardt et al.Nutraceuticals have gained recognition as adjuvant therapies in cancer treatment due to their non-toxic and protective properties. Among various natural products, pomegranate peel with high antioxidant capacity and rich polyphenol content suggest potential anticancer properties. Previous studies have shown promising anticancer effects of other parts of the pomegranate. The purpose of this research is to compare the effectiveness of Pomegranate … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 1 · 13 May 2025 · 5,582 accessesView PDFCite
Research ArticleOpen accessIn the abstractInteractivity in VR Therapy: Assessing Efficacy Across Acrophobia SeverityChiew Mei Chan, Soo See Chai, Kok Luong Goh, Sze Kiat SimVirtual Reality (VR) and Artificial Intelligence (AI) have gained popularity in medical treatments, including for acrophobia- a common but often untreated fear of heights. Traditional therapies are often expensive and complex, making VR therapy a convenient and safe alternative. This study evaluates the efficacy of an AI-augmented interactivity VR therapy for acrophobia, focusing on user satisfaction and treatment outcomes. Graded … …Journal of Computer Science, Vol. 21, Issue 5 · 16 Apr 2025 · 5,864 accessesView PDFCite
Literature ReviewOpen accessIn the abstractUnraveling Sterile Inflammation in Atherosclerosis: Mechanisms, Implications and Therapeutic StrategiesAnastasia Vladimirovna Poznyak, Vasily Nikolaevich Sukhorukov, Anton Yuvenalievich Postnov et al.Atherosclerosis, a leading factor in the development of cardiovascular diseases, is a complex and multifaceted condition with inflammation emerging as a pivotal determinant of its pathogenesis. This review comprehensively investigates the role of sterile inflammation in atherosclerosis and deliberates on potential therapeutic interventions targeting this underlying mechanism. Despite advancements in the understanding of atherosclerosis, diagnosing, preventing, and choosing effective treatment … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 4 Mar 2025 · 3,965 accessesView PDFCite
Literature ReviewOpen accessIn the abstractAtherosclerosis as Age-Related Disease: The Potential of Sirtuins TreatmentAnastasia Vladimirovna Poznyak, Victor Yurievich Glanz, Vasily Nikolaevich Sukhorukov et al.Atherosclerosis, a global health concern, has attracted researchers worldwide due to its severe consequences. The elderly are particularly susceptible to cardiovascular diseases and events, making them a high-risk group. Although gaps in our understanding of atherosclerosis pathogenesis persist, it is evident that oxidative stress, endothelial dysfunction, inflammation, mitochondrial dysfunction, and autophagy impairments are key components of its development. Remarkably, these … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 16 May 2024 · 4,717 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of the Renoprotective Effects of Valsartan in Methotrexate-Induced Acute Kidney Injury in RatsDina KutbiMethotrexate (MTX) is a widely used chemotherapeutic agent known for its nephrotoxic effects, which can lead to acute kidney injury in hospitalized patients. However, the mechanism by which MTX induces nephrotoxicity is not entirely clear, but it is believed to involve oxidative stress and direct toxic effects on renal tubules. Valsartan, an angiotensin II receptor blocker, has been shown to … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 4 May 2024 · 4,571 accessesView PDFCite