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11 results for “angiogenesis and cancer”
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Research ArticleOpen accessIn the keywordsFocal Adhesion Kinase: An Old Protein with New RolesAtul Kumar Pandey, Sonal Somvanshi, Vivek Pratap SinghFocal adhesion kinase, FAK is a tyrosine kinase which is prominently localized to focal adhesions and therefore its name, is an indispensable protein in integrin signaling. Since the discovery of FAK, this tyrosine kinase had been shown to regulate a variety of cell behavior like cell migration, proliferation, apoptosis and metastasis which makes this molecule at a centre stage of … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 13 Mar 2012 · 8,439 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effect of Lactobacillus Plantarum and Bacterial Peptidoglycan on the Growth of Mouse Tumors in vivo and in vitroArpa Aintablian, Dalal F. Jaber, Mary Ann Jallad, Alexander M. AbdelnoorSome members of the microbiota have been shown to be effective strategies for inhibiting tumor growth through stimulation of host anti-tumor immune responses. Anti-tumor immune effects were observed when Lactobacillus plantarum (Lp), a member of the gut microbiota, was used to treat colorectal cancer in mice. Moreover, constituents of bacteria, including peptidoglycan (PG), have been shown to exhibit tumoricidal effects. … …American Journal of Immunology, Vol. 13, Issue 3 · 23 Sep 2017 · 8,451 accessesView PDFCite
EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite
Review ArticleOpen accessIn the abstractVascular Endothelial Growth Factor: An Overview Across Multiple Disease ConditionsMiriam CanaveseVascular Endothelial Growth Factor (VEGF) is the major player in the regulation of physiological angiogenesis as well as it has also been implicated in pathological angiogenesis, associated with cancers and other conditions, among which psoriasis, autoimmune diseases and visual loss in macular degeneration. Interestingly, three regulatory Single Nucleotide Polymorphisms (rSNPs) in the promoter region of VEGF-A gene have been significantly … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 1 · 6 May 2015 · 7,099 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Hypoxia-Inducible Factor-1α Signaling Pathway and its Relation to Cancer and ImmunologyBruno R.B. Pires, Andre L. Mencalha, Gerson M. Ferreira et al.Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is present in all metazoans from early embryonic development throughout adult life. It plays a major roles in the different stress responses that are triggered by low Oxygen (O2) levels and its expression is associated with cell survival. HIF-1 is a heterodimer protein that comprises the subunits HIF-1α and HIF-1β. The … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 8,482 accessesView PDFCite
Research ArticleOpen accessIn the abstractPlant Pectin: A Potential Source for Cancer SuppressionSuryakant K. Niture, Lubna RefaiPectin is a branched polysaccharide present widely in a variety of fruits. It has been of high interest to cancer biologists due to its involvement in metal/carcinogen detoxification and its anti-carcinogenic properties. In particular, Citrus Pectin (CP) and Modified Citrus Pectin (MCP) have been shown to have a significant inhibitory role in cancer cell metastasis, invasion, angiogenesis and survival. The … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 18 Apr 2013 · 15,524 accessesView PDFCite
Research ArticleOpen accessIn the abstractMicrornas are Not That Small to IgnoreSanjeev Kumar Srivastava, Sonal Somvanshi, Vivek Pratap SinghMicroRNAs (miRNAs) are small, noncoding RNA molecule that negatively regulates gene expression by causing either degradation or translational inhibition of their target mRNAs. These miRNAs are key regulators of various biological processes such as differentiation, maturation and maintenance of immune homeostasis. Furthermore, deregulated expression of miRNA has now been shown to regulate several disease processes by regulating tumorigenesis, angiogenesis, apoptosis … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 2 · 22 Jun 2012 · 8,456 accessesView PDFCite
Research ArticleOpen accessIn the abstractRelationship Between Blood Fibrinogen Concentration and Pathological Features of Cancer Patients: A 139-case Clinical StudyDa-Yong Lu, Xue-Liang Chen, Min Huang et al.Angiogenesis and coagulation are among the most consistent host responses to the presence of a malignant tissue. Pathological angiogenesis and coagulation are often occurred in patients with solid tumors, especially in the occurrence of neoplasm metastasis and as targets for anti-metastatic drugs such as antiangiogenesis agents, coagulation-mediated agents and anticancer drugs. Since fibrinogen (Fib) is the most abundant and key … …OnLine Journal of Biological Sciences, Vol. 7, Issue 1 · 4 Sep 2010 · 7,859 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effects of Recombinant Human Erythropoietin and Tamoxifen on Growth and Angiogenesis of Mammary Tumor in Sprague-Dawley RatA. K. Sairah, A. Rasedee, O. Sheikh et al.Problem statement: Erythropoietin receptor (EPOR) has been detected in breast cancer cells and speculated to be involved in cancer growth, viability and angiogenesis. This has risen suspicious that EPO administration may enhance the severity of cancer. Approach: This study was undertaken to determine the effects of rHuEPO, Tamoxifen and their combination on the growth and angiogenesis of mammary tumor. Female … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 1 · 31 Mar 2009 · 7,804 accessesView PDFCite
Research ArticleOpen accessIn the abstractCorrelation between Tissue and Released VEGF Levels in Urine of Bladder Cancer PatientsMenha Swellam, Abdulla A.A. El-AalPurpose. Angiogenesis is a complex multistep process essential for tumor growth. Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen and vascular permeability-inducing agent. The aim of this study was to analyze whether tissue and urinary VEGF levels of bladder cancer patients are correlated and study their correlation with classical clinicopathological parameters and bilharizial bladder cancer patients. The … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,639 accessesView PDFCite