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Author

Bruno R.B. Pires

Instituto Nacional de Câncer José Alencar Gomes da Silva, Brazil
1 article in our journals

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Research ArticleOpen accessThe Hypoxia-Inducible Factor-1α Signaling Pathway and its Relation to Cancer and ImmunologyBruno R.B. Pires, Andre L. Mencalha, Gerson M. Ferreira et al.Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is present in all metazoans from early embryonic development throughout adult life. It plays a major roles in the different stress responses that are triggered by low Oxygen (O2) levels and its expression is associated with cell survival. HIF-1 is a heterodimer protein that comprises the subunits HIF-1α and HIF-1β. The … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 8,482 accessesView PDFCite