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82 articles for “Underlying Mechanism”
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Research ArticleOpen accessEvery word in the titleUPLC-QTOF-MS/MS and Bioinformatics Association Analysis Reveals the Pharmacodynamic Flavonoids in Scutellaria barbata and the Underlying Anti-Colorectal Cancer MechanismYi-Jie Cheng, Xin-Yun Du et al.Colorectal Cancer (CRC) is one of the most common and deadly malignancies worldwide, with no safe and effective drugs. The flavonoid in Scutellaria Barbata D. Don (SB) showed a good therapeutic effect on CRC. However, the pharmacodynamic substances and underlying mechanisms have not been elucidated which limited its development and application. This study aimed to identify the main flavonoid in … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 4 · 14 Nov 2023 · 5,404 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Beneficial Effect of Asiaticoside on Experimental Neuropathy in Diabetic RatsChonlathip Thipkaew, Jintanaporn Wattanathorn, Supaporn MuchimapuraThough diabetic neuropathy produces high impact on quality of life, annual cost and morbidities, the therapeutic efficacy is still not in a satisfaction level. Based on the crucial role of oxidative stress on the pathophysiology of diabetic neuropathy and the improvement of this condition induced by antioxidant, we hypothesized that asiaticoside, a substance possessing antioxidant activity, could provide beneficial effect. … …American Journal of Applied Sciences, Vol. 9, Issue 11 · 31 Aug 2012 · 7,054 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPhyllanthus Amarus Facilitates the Recovery of Peripheral Nerve after InjuryPanakpaporn Wannannond, Jintanaporn Wattanathorn, Supaporn Muchimapura et al.Problem statement: Peripheral nerve injuries are associated with morbidity and outcomes of peripheral nerve repair are poor. Moreover, it can subsequently leads to economic or social disability. Recent findings have shown that oxidative stress plays an important role on the functional recovery retardation of peripheral nerve. However, the impairment mentioned earlier is counteracted by antioxidant. Therefore, this study was carried … …American Journal of Applied Sciences, Vol. 9, Issue 7 · 10 May 2012 · 7,100 accessesView PDFCite
Literature ReviewOpen accessIn the abstractA Review of Cellular Mechanism of Pulsed Electromagnetic Field (PEMF) in Inhibiting Adipogenesis of Mesenchymal Stem CellsPuji Sari, Nuzli Fahdia Mazfufah, Umiatin et al.PEMF is a method that utilizes electric current using a coil that is powered by dynamic electric current, it will cause a dynamic magnetic field in the coil. In the last few decades, it is known that PEMF has the potential to be used as a modality in the treatment of obesity. For this reason, PEMFs have been studied in … …OnLine Journal of Biological Sciences, Vol. 23, Issue 2 · 26 Mar 2023 · 6,043 accessesView PDFCite
Research ArticleOpen accessIn the abstractFunctional Role of Vitelline Glands and Mehlis Gland in the Process of Resistant Egg Shell Formation in TrematodesRimma UaliyevaThe study of the functional morphology of the reproductive system of trematodes, as well as its individual parts, provides an opportunity to solve an important problem that plays a huge role in theoretical and practical terms as the directed regulation of the fecundity of endoparasites. The article is devoted to the study of the functional role of vitelline glands and … …OnLine Journal of Biological Sciences, Vol. 23, Issue 2 · 28 Feb 2023 · 6,371 accessesView PDFCite
Literature ReviewOpen accessIn the abstractUnraveling Sterile Inflammation in Atherosclerosis: Mechanisms, Implications and Therapeutic StrategiesAnastasia Vladimirovna Poznyak, Vasily Nikolaevich Sukhorukov, Anton Yuvenalievich Postnov et al.Atherosclerosis, a leading factor in the development of cardiovascular diseases, is a complex and multifaceted condition with inflammation emerging as a pivotal determinant of its pathogenesis. This review comprehensively investigates the role of sterile inflammation in atherosclerosis and deliberates on potential therapeutic interventions targeting this underlying mechanism. Despite advancements in the understanding of atherosclerosis, diagnosing, preventing, and choosing effective treatment … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 4 Mar 2025 · 3,973 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Maize Potato Intercropping and Different Fertilization Methods on Rhizosphere Soil Microorganisms and Yield of PotatoHuanjin Ma, Shengguang Xu et al.A field experiment with three replicates was conducted to explore the effects of maize-potato intercropping and different nitrogen application strategies on rhizosphere soil microorganisms and potato yield. Microbial community analysis was based on relative abundance. Maize-potato intercropping improves land use efficiency, yet how differentiated nitrogen management regulates rhizosphere microecology and potato productivity in this system remains unclear. Clarifying nitrogen-mediated shifts … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 14 Sep 2026 · 814 accessesView PDFCite
Research ArticleOpen accessIn the abstractDecoding Lung Cancer: PLAU as a Critical Driver and Diagnostic MarkerStanley Cho, Min Gyeong KimLung cancer remains a leading cause of cancer-related mortality, and understanding its underlying molecular mechanisms is critical for developing targeted therapies. We developed a novel tool called the Transcriptome-TCGA Integration (TTI), which combines in vitro transcriptome data with clinical datasets from the Cancer Genome Atlas (TCGA). TTI allows for the identification of key genes and pathways involved in lung cancer, … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,429 accessesView PDFCite
Literature ReviewOpen accessIn the abstractCorrelation of Atherosclerosis and Osteoarthritis, the Role of Inflammation in the Pathogenesis of Osteoarthritis and AtherosclerosisAnastasia V. Poznyak, Nikolay A. Orekhov, Aleksandra Sergeevna Utkina et al.Cardiovascular Diseases (CVD) rank among the leading causes of death globally, accounting for a substantial proportion of mortality rates and affecting millions of individuals. Risk factors such as ageing, obesity, diabetes and a sedentary lifestyle contribute significantly to the prevalence of CVD. Osteoarthritis (OA), on the other hand, is one of the most common joint disorders, affecting a large segment … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,777 accessesView PDFCite
Literature ReviewOpen accessIn the abstractPotential Therapies for Mitochondrial Diseases Caused by mtDNA MutationsAnastasia V. Poznyak, Nikolay A. Orekhov, Dmitry Felixovich Beloyartsev et al.Mitochondrial diseases, caused by mutations in mitochondrial DNA (mtDNA), present significant genetic and clinical complexities that challenge accurate diagnosis and treatment. This review examines the critical molecular mechanisms underlying these disorders, particularly the role of heteroplasmy, where mixtures of mutated and normal mtDNA influence disease severity, and the nuclear-mitochondrial DNA interactions that compound diagnostic and therapeutic challenges. The threshold effect, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,750 accessesView PDFCite