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85 results for “Underlying Mechanism”
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Research ArticleOpen accessEvery word in the titleUPLC-QTOF-MS/MS and Bioinformatics Association Analysis Reveals the Pharmacodynamic Flavonoids in Scutellaria barbata and the Underlying Anti-Colorectal Cancer MechanismYi-Jie Cheng, Xin-Yun Du et al.Colorectal Cancer (CRC) is one of the most common and deadly malignancies worldwide, with no safe and effective drugs. The flavonoid in Scutellaria Barbata D. Don (SB) showed a good therapeutic effect on CRC. However, the pharmacodynamic substances and underlying mechanisms have not been elucidated which limited its development and application. This study aimed to identify the main flavonoid in … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 4 · 14 Nov 2023 · 5,398 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Beneficial Effect of Asiaticoside on Experimental Neuropathy in Diabetic RatsChonlathip Thipkaew, Jintanaporn Wattanathorn, Supaporn MuchimapuraThough diabetic neuropathy produces high impact on quality of life, annual cost and morbidities, the therapeutic efficacy is still not in a satisfaction level. Based on the crucial role of oxidative stress on the pathophysiology of diabetic neuropathy and the improvement of this condition induced by antioxidant, we hypothesized that asiaticoside, a substance possessing antioxidant activity, could provide beneficial effect. … …American Journal of Applied Sciences, Vol. 9, Issue 11 · 31 Aug 2012 · 7,051 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPhyllanthus Amarus Facilitates the Recovery of Peripheral Nerve after InjuryPanakpaporn Wannannond, Jintanaporn Wattanathorn, Supaporn Muchimapura et al.Problem statement: Peripheral nerve injuries are associated with morbidity and outcomes of peripheral nerve repair are poor. Moreover, it can subsequently leads to economic or social disability. Recent findings have shown that oxidative stress plays an important role on the functional recovery retardation of peripheral nerve. However, the impairment mentioned earlier is counteracted by antioxidant. Therefore, this study was carried … …American Journal of Applied Sciences, Vol. 9, Issue 7 · 10 May 2012 · 7,098 accessesView PDFCite
Literature ReviewOpen accessIn the abstractUnraveling Sterile Inflammation in Atherosclerosis: Mechanisms, Implications and Therapeutic StrategiesAnastasia Vladimirovna Poznyak, Vasily Nikolaevich Sukhorukov, Anton Yuvenalievich Postnov et al.Atherosclerosis, a leading factor in the development of cardiovascular diseases, is a complex and multifaceted condition with inflammation emerging as a pivotal determinant of its pathogenesis. This review comprehensively investigates the role of sterile inflammation in atherosclerosis and deliberates on potential therapeutic interventions targeting this underlying mechanism. Despite advancements in the understanding of atherosclerosis, diagnosing, preventing, and choosing effective treatment … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 4 Mar 2025 · 3,965 accessesView PDFCite
Literature ReviewOpen accessIn the abstractA Review of Cellular Mechanism of Pulsed Electromagnetic Field (PEMF) in Inhibiting Adipogenesis of Mesenchymal Stem CellsPuji Sari, Nuzli Fahdia Mazfufah, Umiatin et al.PEMF is a method that utilizes electric current using a coil that is powered by dynamic electric current, it will cause a dynamic magnetic field in the coil. In the last few decades, it is known that PEMF has the potential to be used as a modality in the treatment of obesity. For this reason, PEMFs have been studied in … …OnLine Journal of Biological Sciences, Vol. 23, Issue 2 · 26 Mar 2023 · 6,041 accessesView PDFCite
Research ArticleOpen accessIn the abstractFunctional Role of Vitelline Glands and Mehlis Gland in the Process of Resistant Egg Shell Formation in TrematodesRimma UaliyevaThe study of the functional morphology of the reproductive system of trematodes, as well as its individual parts, provides an opportunity to solve an important problem that plays a huge role in theoretical and practical terms as the directed regulation of the fecundity of endoparasites. The article is devoted to the study of the functional role of vitelline glands and … …OnLine Journal of Biological Sciences, Vol. 23, Issue 2 · 28 Feb 2023 · 6,367 accessesView PDFCite
Research ArticleOpen accessIn the abstractBlood-Circulating Type 2 Follicular Helper T Cells in Pediatric Allergy PatientsMasaaki Hamada, Yoshihiko Sakurai, Tomohiro TakedaPediatric allergic diseases are primarily caused by an IgE-dependent immunological reaction. Despite studies reporting the involvement of T follicular Helper (TfH) cells, especially type 2 TfH cells, in class-switching to IgE production in B cells, TfH subset skewing in peripheral blood in pediatric allergy patients remains to be elucidated. This study aimed to investigate the possible involvement of type 2 … …American Journal of Immunology, Vol. 16, Issue 1 · 18 Jun 2020 · 7,505 accessesView PDFCite
Research ArticleOpen accessIn the abstractONCODIAG Select and Test (ST) Algorithm: An Approximate Clinical Reasoning Model for Diagnosing and Monitoring Breast CancerO.N. Oyelade, A.A. Obiniyi, S.B. JunaiduClinical reasoning involves coordinated thinking strategies targeted at gathering and analyzing relevant information to arrive at a high-quality clinical solution to patients' medical problems. The correctness and proper choice of clinical reasoning approach chosen by a clinician or machine affect the accuracy and acceptability of the diagnosis; moreover, another challenge that usually surfaces during clinical reasoning is the burden of … …Current Research in Bioinformatics, Vol. 9, Issue 1 · 22 Feb 2020 · 8,936 accessesView PDFCite