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10 results for “Plasmodium falciparum”
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Research ArticleOpen accessPhrase in the titleGenetic Diversity in Merozoite Surface Protein.1 of Plasmodium falciparum in Highlands: Wamena Papua IndonesiaRosye Hefmi Rechnelty Tanjung, Yulius Sarungu, Meidy Johana Imbiri et al.Malaria is the first killer as well as endemic disease in highland, lowland and coastal areas of Papua. In 2016 there were 160 thousands cases noted and 80% of the cases were caused by Plasmodium falciparum. Total sample for this study were provided by a clinical trial conducted from May to June 2018 in the regional hospital of Puncak Jaya, … …American Journal of Infectious Diseases, Vol. 14, Issue 4 · 11 Jan 2019 · 7,753 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleStage Specificity of Eurycomanone Isolated from Eurycoma longifolia on Plasmodium falciparum CyclesEti Nurwening Sholikhah, Mahardika Agus Wijayanti, Ratna Asmah Susidarti et al.Eurycomanone is the most active compounds in the roots of Eurycoma longifolia and shown to have in vitro antiplasmodial activity. However, the stage of Plasmodium falciparum cycles which are sensitive to eurycomanone have not been investigated. This study was conducted to investigate stage specificity of eurycomanone at various stages of P. falciparum life cycles. Stage specificity of eurycomanone at various … …American Journal of Pharmacology and Toxicology, Vol. 11, Issue 1 · 16 Jan 2016 · 7,739 accessesView PDFCite
Case ReportOpen accessPhrase in the titleA Case Report of Severe Malaria Due to Plasmodium falciparum Malaria Complicated by Symmetrical Peripheral Gangrene (SPG) at the Matlaboul Fawzaini National Hospital Center, Touba, SenegalJules Yindoni Zande, Ndeye Fatou Ngom et al.Malaria remains a major public health problem worldwide, particularly in Africa. Symmetrical Peripheral Gangrene (SPG) is a distal ischemic lesion affecting at least two extremities in the absence of proximal arterial obstruction and vasculitis. It is a rare and severe clinical entity. Its association with malaria is rare, with approximately 27 cases reported worldwide, mostly in Asia. A 15-year-old male … …American Journal of Infectious Diseases, Vol. 21, Issue 1 · 22 Jan 2026 · 2,806 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleDetermination of Optimum Values of Descriptors to Set Filters for Synthetic Tri-Pyrrole Derivatives (Prodiginines) Against Multi Drug Resistant Strain of Plasmodium FalciparumVijay H. Masand, Devidas T. Mahajan, Eslam Pourbasheer et al.In the present study, we have carried out extensive non-linear Quantitative-Structure Activity Relationship (QSAR) analysis to correlate in vitro anti-malarial activity against multi drug resistant strain of Plasmodium falciparum. Forty-three synthetic prodiginines with different structural features were used for their potential antimalarial activity. Linear, bilinear, biexponential and parabolic equations were developed. These equations were compared to determine the optimum values … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 14,141 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIn vitro Anti Plasmodial Activity of Enicostemma littoraleSanket Soni, Sarita GuptaProblem statement: Malaria is a prevalent disease in India. The problem of drug resistance is worsening. Hence, new effective and affordable antimalarial drugs are very much needed. The long-established use of quinine and the more recent introduction of artemisinin as highly effective anti malarials demonstrate that plant species are an important resource for the discovery of new anti malarial agents. … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 7,707 accessesView PDFCite
Research ArticleOpen accessIn the abstractWhy Continue Studying HRP2 and HRP3 in Malaria?María Luz Gunturiz, Pablo Enrique Chaparro, Gabriel Carrasquilla, Mónica Marcela JiménezThe main malaria control strategy is rapid and accurate diagnosis followed by effective treatment. The quality of the diagnosis is relevant, since an erroneous diagnosis can generate an increase in morbidity and mortality significantly. The World Health Organization (WHO) has recommended that all patients with suspected malaria be diagnosed by microscopy or a Rapid Diagnostic Test (RDT) before treatment. Microscopy … …American Journal of Infectious Diseases, Vol. 16, Issue 3 · 24 Aug 2020 · 6,897 accessesView PDFCite
Letters to the EditorOpen accessIn the abstractIs Hydroxychloroquine a Safe and Effective Choice for Covid-19 ProphylaxisRodrigo Moisés de Almeida-Leite, Tais Rondello Bonatti, Carolina Rodrigues Ponzoni et al.The authors speculate about the possibility of Hydroxychloroquine as Covid-19 Phrophylaxis in the dose of 400 mg per week. The authors compared the experience of Malaria phrophylaxis in this dose, with acceptable safety profile. Also, we compared in vitro susceptibility of SARS-Cov-2 with that of Plasmodium falciparum. This agent show significant higher potency for the first. Also, the extended Half-life … …American Journal of Infectious Diseases, Vol. 16, Issue 3 · 29 Jul 2020 · 7,048 accessesView PDFCite
EditorialOpen accessIn the abstractAre Heat Shock Proteins Druggable Candidates?Tawanda Zininga, Addmore ShonhaiBanumathy, G., V. Singh, S.R. Pavithra and U. Tatu, 2003. Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. J. Biol. Chem., 278: 18336-18345. DOI: 10.1074/jbc.M211309200 Brehmer, D., S. Rudiger, C.S. Gassler, D. Klostermeier and L. Packschies et al., 2001. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nature Structural Molecular … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 2 Dec 2014 · 8,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractPlasmodium Pre-Erythrocytic Stages: Biology, Whole Parasite Vaccines and Transgenic ModelsKota Arun Kumar, Satish MishraMalaria remains one of the world’s worst health problems, which causes 216 million new cases and approximately 655,000 deaths every year WHO World Malaria Report, 2011. Malaria transmission to the mammalian host is initiated through a mosquito bite that delivers sporozoites into the vertebrate host. The injected sporozoites are selectively targeted to liver which is the first obligatory step in … …American Journal of Immunology, Vol. 8, Issue 3 · 13 Sep 2012 · 8,263 accessesView PDFCite
Research ArticleOpen accessIn the abstractIntrinsically Unstructured Proteins: Potential Targets for Drug DiscoveryPathan Salma, Chintan Chhatbar, Sriram SeshadriProblem statement: The function of a protein is dependent on its three-dimensional structure. However, numerous proteins lacking intrinsic globular 3D structure under physiological conditions had been recognized. These proteins are frequently involved in some of the most critical cellular control mechanisms and it appears that their rapid turnover, aided by their unstructured nature in the unbound state, provides a level … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,578 accessesView PDFCite