Is Hydroxychloroquine a Safe and Effective Choice for Covid-19 Prophylaxis
Rodrigo Moisés de Almeida-Leite1, Tais Rondello Bonatti2, Carolina Rodrigues Ponzoni3, Ana Cristina da Cunha Korndorfer4 & Solange Bifani Tavares da Silva1 Show affiliations
- Faculdade de Medicina de Jundiaí, Brazil
- Universidade Paulista, Brazil
- Unimed Itatiba, Brazil
- Faculdade de Medicina de Teresópolis, Brazil
American Journal of Infectious Diseases, Volume 16, Issue 3, pp. 118–119 · doi.org/10.3844/ajidsp.2020.118.119
Abstract
The authors speculate about the possibility of Hydroxychloroquine as Covid-19 Phrophylaxis in the dose of 400 mg per week. The authors compared the experience of Malaria phrophylaxis in this dose, with acceptable safety profile. Also, we compared in vitro susceptibility of SARS-Cov-2 with that of Plasmodium falciparum. This agent show significant higher potency for the first. Also, the extended Half-life (40-50 days) make it an acceptable choice for prophylaxis. We also cite Brazilian experience with Chloroquinated Salt in the 1950s, its efficacy and feasibility. Lastly, we suggest that clinical trials should be conducted test this hypothesis.
Licence and reuse
Open access. This article is licensed under a Creative Commons Attribution 3.0 Licence (CC BY 3.0), as printed on the article, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original authors and the source. No permission is needed.
How to reuse this articleResponses (0)
About this article
de Almeida-Leite, R. M., Bonatti, T. R., Ponzoni, C. R., Korndorfer, A. C. D. C. & da Silva, S. B. T. (2020). Is Hydroxychloroquine a Safe and Effective Choice for Covid-19 Prophylaxis. American Journal of Infectious Diseases, 16(3), 118–119. https://doi.org/10.3844/ajidsp.2020.118.119
- Licence
- CC BY 3.0
- Issue
- Volume 16, Issue 3
- Policies
- Editorial independenceUse of generative AIData availabilityAppeals and complaints
- Version
- Version of record