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100 results for “Pathogenesis”
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Literature ReviewOpen accessEvery word in the titleMitochondrial Dysfunction Model in the Pathogenesis of Inflammatory Response Development in ObesityAlexander Blagov, Varvara Orekhova et al.Obesity is one of the growing problems of modern society. Although currently used methods of treating obesity, including diet, exercise, and drug therapy, have shown their applicability to more effectively combat obesity, an understanding of the pathogenesis of this disease is required. One of the insufficiently studied factors in the pathogenesis of obesity is the development of mitochondrial dysfunction understanding … …OnLine Journal of Biological Sciences, Vol. 24, Issue 1 · 19 Nov 2023 · 4,933 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleThe Role of the Microbial Biofilm in the Pathogenesis of Periodontal Disease: An UpdateAndreas L. Ioannou, Konstantinos Siormpas, Miltiades E. Mitsias, Georgios A. KotsakisMicrobial biofilm is generally considered to be an etiologic factor for the diseases of the periodontium and has been and continues to be the main focus of avid periodontal researchers. Based on our current understanding of the role of the biofilm in the pathogenesis of periodontal disease, each different species seems to have a specific role to fulfill in this … …Current Research in Dentistry, Vol. 5, Issue 1 · 6 May 2015 · 6,906 accessesView PDFCite
Literature ReviewOpen accessEvery word in the titleCorrelation of Atherosclerosis and Osteoarthritis, the Role of Inflammation in the Pathogenesis of Osteoarthritis and AtherosclerosisAnastasia V. Poznyak, Nikolay A. Orekhov, Aleksandra Sergeevna Utkina et al.Cardiovascular Diseases (CVD) rank among the leading causes of death globally, accounting for a substantial proportion of mortality rates and affecting millions of individuals. Risk factors such as ageing, obesity, diabetes and a sedentary lifestyle contribute significantly to the prevalence of CVD. Osteoarthritis (OA), on the other hand, is one of the most common joint disorders, affecting a large segment … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,769 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleFrom Health to Disease: Functional Insights of Scavenger Receptor Class B Type I in Lipid Metabolism and Disease PathogenesisSujina Simon Sailet, Poornima Ajay Manjrekar, Santosh Rai et al.Scavenger receptor class B type I (SR-B1) has caught considerable interest among the scientific community due to its pivotal role in several biological and pathological processes. It is a multifunctional integral membrane protein and multiligand receptor encoded by the SCARB1 gene. SR-B1 has a wide distribution, primarily in the liver as well as steroidogenic organs including the gonads and adrenal … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 11 Jul 2025 · 3,667 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleUnveiling the Impact of Endogenous Sialidases on Human Non-Infectious Disease PathogenesisRaisa Sergeevna Surkova, Anastasia Vladimirovna Poznyak, Dmitry Alexandrovich Kashirskikh et al.In our review, we have compiled existing information regarding the role of endogenous sialidases (neuraminidases) in the initiation and development of various non-infectious processes in humans. Precisely, pathologies of the cardiovascular system, tumor formations, neurological and metabolic disorders, and hereditary diseases. Sialidases appeared to be widely involved in a variety of human pathologies. An increase or decrease in the enzymatic … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 10 Feb 2024 · 4,546 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleRCMV ALL-03 Model and Study of CMV Pathogenesis in Congenital InfectionAshwaq Ahmed Abdullah, Krishnan Nair Balakrishnan, Yusuf Abba et al.Cytomegalovirus (CMV) is one of the most commonly studied members of the Herpesviridae family. So far several strains have been identified but human CMV (HCMV) remains the most important due to its ability to infect humans and also cross the placenta causing neonatal infection and mortality. However, there are several limitations in the study of this strain which includes availability … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 3 · 18 Jul 2015 · 8,061 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMonocytes and their Role in Human Immunodeficiency Virus PathogenesisTara Sassé, Jingqin Wu, Li Zhou, Nitin K. SaksenaMonocytes play several significant immunological roles during HIV infection. The phenotypic pliability and the cellular differentiation ability monocytes possess are crucial to the ways they combat infections and control inflammatory processes. The purpose of this review is to provide a comprehensive snapshot of the importance of monocytes in HIV-1 infection and pathogenesis. Moreover, this review also provides newly emerging data … …American Journal of Infectious Diseases, Vol. 8, Issue 2 · 31 Jul 2012 · 8,018 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleInterplay of Cytokines and Chemokines in the Pathogenesis of Systemic Lupus ErythematosusDilip Shah, Ajay Wanchu, Archana BhatnagarProblem statement: Dysbalance of T-helper-cell (Th) cytokines and chemokines was suggested to contribute to the pathogenesis of Systemic Lupus Erythematosus (SLE). Recent reports suggest the involvement of cytokines and chemokines in the pathogenesis of SLE, but their relationship with each other and particularly in the severity of disease, was not yet understood. We analyzed the interaction between cytokines and chemokines … …American Journal of Immunology, Vol. 7, Issue 3 · 21 Dec 2011 · 8,161 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleGENE IMPRINTING: ENGRAVING THE PATHOGENESIS OF HERIDETARY DISEASESSandeep Satapathy, Roshan Kumar Singh, Harikrishnan RajendranGene imprinting has conduited the scope of our understanding of phenotypic expression and its corelation with constituent genotype. It is an epigenetic process that involves DNA methylation and histone modulation to attain monoallelic gene expression without altering the genetic sequences. A distinctive model of non-mendelian genetics, imprinting extends the control over expression of traits and selection of the allele that … …American Journal of Immunology, Vol. 10, Issue 1 · 12 Feb 2014 · 7,682 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRendezvous with Tat: Transactivator of Transcription during Human Immunodeficiency Virus PathogenesisSneham Tiwari, Madhavan P.N. Nair, Shailendra K. SaxenaAcquired immune deficiency syndrome is a deadly disease caused by HIV, declared as a global catastrophe engulfing millions of lives per year. It took ~1.8 million lives in the year 2010 alone, as per reports of UNAIDS. HIV-1 is an enveloped retrovirus, having genome composed of two copies of ssRNA. It attacks the T-lymphocytes of the hosts, causes several multifaceted … …American Journal of Infectious Diseases, Vol. 8, Issue 2 · 31 Jul 2012 · 7,625 accessesView PDFCite