Unveiling the Impact of Endogenous Sialidases on Human Non-Infectious Disease Pathogenesis

In our review, we have compiled existing information regarding the role of endogenous sialidases (neuraminidases) in the initiation and development of various non-infectious processes in humans. Precisely, pathologies of the cardiovascular system, tumor formations, neurological and metabolic disorders, and hereditary diseases. Sialidases appeared to be widely involved in a variety of human pathologies. An increase or decrease in the enzymatic activity of sialidase can be a triggering factor in the pathogenesis of these disorders. This led us to the conclusion that enzymes of this family are essential for the normal functioning of human organisms. Therefore, with a detailed study of the characteristics and functions of sialidase, it is possible to develop new and effective diagnostic methods, treatment strategies, and prevention of many important human diseases. In this review, we are linking all sialidase-related features of different diseases, which can set a direction for further studies.