Research ArticleOpen accessIn the keywordsFrom Humans to Dogs and Back: The Translational Lesson of Metronomic ChemotherapyAlessio Pierini, Guido Bocci, Mario Giorgi et al.The main priority in veterinary oncology is to maintain patient quality of life. It is important that new chemotherapy strategies aim to minimize side effects, thus making the treatment attractive for owners as well as their pets. Metronomic chemotherapy has been shown to have an important stabilizing effect on human cancer (including chemotherapy-resistant disease) resulting in prolonged clinical benefit. In … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 4 · 31 Dec 2012 · 7,738 accessesView PDFCite
Case ReportOpen accessIn the keywordsThe Diagnostic and Etiologic Challenge of Myocarditis in Oncologic Patients: Acute Myocarditis During Induction Treatment with All-Trans Retinoic AcidNúria Coma, Sergio Moral, Rosa Coll et al.Myocarditis is an inflammatory disease of the myocardium characterized by myocardial infiltration with inflammatory cells and non-ischemic myocytic necrosis. Its diagnosis is based on clinical, electrocardiogram, laboratory and echocardiographic parameters and also cardiac magnetic resonance or endomyocardial biopsy when possible. It occurs primarily as a result of infections that include viruses, parasites, bacteria and fungi. Moreover, there are other causes … …American Journal of Infectious Diseases, Vol. 17, Issue 3 · 7 Jun 2021 · 7,013 accessesView PDFCite
Research ArticleOpen accessIn the abstractDecoding Lung Cancer: PLAU as a Critical Driver and Diagnostic MarkerStanley Cho, Min Gyeong KimLung cancer remains a leading cause of cancer-related mortality, and understanding its underlying molecular mechanisms is critical for developing targeted therapies. We developed a novel tool called the Transcriptome-TCGA Integration (TTI), which combines in vitro transcriptome data with clinical datasets from the Cancer Genome Atlas (TCGA). TTI allows for the identification of key genes and pathways involved in lung cancer, … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,424 accessesView PDFCite
Research ArticleOpen accessIn the abstractAI-Guided Anatomical Landmark and Abnormality Detection for Autonomous Endoscopy ExaminationMd Shakhawat Hossain, Munim Ahmed et al.Aabakken, L., Barkun, A. N., Cotton, P. B., Fedorov, E., Fujino, M. A., Ivanova, E., Kudo, S., Kuznetzov, K., De Lange, T., Matsuda, K., Moine, O., Rembacken, B., Rey, J., Romagnuolo, J., Rösch, T., Sawhney, M., Yao, K., & Waye, J. D. (2014). Standardized endoscopic reporting. Journal of Gastroenterology and Hepatology, 29(2), 234–240. https://doi.org/10.1111/jgh.12489 Aliyi, S., Dese, K., & Raj, … …Journal of Computer Science, Vol. 20, Issue 8 · 29 May 2024 · 6,783 accessesView PDFCite
Research ArticleOpen accessIn the abstractRelease of Endogenous Chondroitin Sulfate and Heparin as Consequence of Dysregulated Proteolysis in COVID-19Marco RuggieroInfection by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), the pathogen responsible for COVID-19, is associated with immune-mediated responses that lead to dysregulated activation of proteolytic enzymes; these contribute to damage to the endothelium, thrombosis, hypercoagulability and other hematologic complications that include thrombotic thrombocytopenia, a complication of severe COVID-19 as well as a potentially fatal adverse effect of COVID-19 vaccination. … …American Journal of Immunology, Vol. 17, Issue 1 · 29 Dec 2021 · 7,688 accessesView PDFCite
Literature ReviewOpen accessIn the abstractDiagnostic Imaging of Gastrointestinal Tumours in Dogs and Cats: A ReviewFrancesco Simeoni, Francesca Del Signore, Rossella Terragni et al.Gastrointestinal tract tumours in dogs and cats are characterized by non-specific clinical presentation and laboratory abnormalities, but require fast identification, characterization and staging. Imaging techniques play a key role in the diagnostic process of these diseases in routine veterinary practice. Survey and contrast radiography may indicate primary or secondary signs of gastric or intestinal neoplasia such as a wall mass, … …American Journal of Animal and Veterinary Sciences, Vol. 15, Issue 2 · 15 Apr 2020 · 9,833 accessesView PDFCite
Research ArticleOpen accessIn the abstractATLCEP: A New Integrated Design that Encompasses the Safety and Efficacy Objectives of Phase I/II TrialsRevathi Ananthakrishnan, Stephanie Green, Mark Chang et al.Several designs, such as designs to find the optimal biological dose, the Eff-Tox design and seamless Phase I/II designs, have been proposed to evaluate both drug toxicity and efficacy as alternatives to the traditional paradigm of a stepwise drug development approach. Here, we first examine the effect of sample and cohort size on the accuracy of dose selection in early … …Current Research in Biostatistics, Vol. 7, Issue 2 · 7 Apr 2018 · 7,980 accessesView PDFCite
EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite