Author

Mark Chang

Boston University, United States

4 articles in our journals

Articles where this person is an author, newest first. People are matched by their name as printed (no ORCID iD is recorded for them), not by name alone; search the name as text to find namesakes too.

Research ArticleOpen accessATLCEP: A New Integrated Design that Encompasses the Safety and Efficacy Objectives of Phase I/II TrialsRevathi Ananthakrishnan, Stephanie Green, Mark Chang et al.Several designs, such as designs to find the optimal biological dose, the Eff-Tox design and seamless Phase I/II designs, have been proposed to evaluate both drug toxicity and efficacy as alternatives to the traditional paradigm of a stepwise drug development approach. Here, we first examine the effect of sample and cohort size on the accuracy of dose selection in early … …Current Research in Biostatistics, Vol. 7, Issue 2 · 7 Apr 2018 · 7,980 accessesView PDF Cite

Research ArticleOpen accessAn Alpha-Exhaustive Multiple Testing ProcedureMark Chang, Xuan Deng, John BalserA multiple testing procedure can be a single-step procedure such as Bonferroni's method or a stepwise procedure such as Hochberg's stepup method and Hommel's method. It can be an α-exhaustive or α-conservative approach. We develop a single α-exhaustive procedure that can improve power 2-5% over Hochberg's and Hommel's methods in common situations when the test statistics are mutually independent. The … …Current Research in Biostatistics, Vol. 6, Issue 2 · 30 Jun 2017 · 8,095 accessesView PDF Cite

Research ArticleOpen accessTrial Design and Analysis with Incomplete Paired DataMark Chang, Jing WangFor a clinical trial design with paired data, it often involves missing observations. In such a case, the data from the trial become a mixture of paired and unpaired data. A commonly used approach for the analysis of the trial data is to ignore the incomplete pairs. Such a treatment of missing data is not statistically efficient. We propose a … …Current Research in Biostatistics, Vol. 5, Issue 2 · 12 Nov 2015 · 7,889 accessesView PDF Cite

Research ArticleOpen accessAdaptive Superiority and Noninferiority Trial Design with Paired Binary DataMark Chang, Jing WangNon-inferiority of a diagnostic test to the standard is a common issue in medical research. For instance, we may be interested in determining if a new diagnostic test is noninferior to the standard reference test because the new test might be inexpensive to the extent that some small inferior margin in sensitivity or specificity may be acceptable. Noninferiority trials are … …Current Research in Biostatistics, Vol. 5, Issue 2 · 7 Sep 2015 · 8,236 accessesView PDF Cite