54 results for “IC50”

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Research ArticleOpen accessIn the keywordsUse of Novel Triphenyltin (IV) Dithiocarbamate Compounds in Assessing the Cytotoxicity and Mode of Cell Death of Acute Lymphoblastic Leukemia Cell Lines, CCRF CEM (CCL-119)Normah Awang, Nur Hidayah Hasrin, Nurul Farahana Kamaludin et al.Chemotherapy and radiotherapy are often used to treat Acute Lymphoblastic Leukemia (ALL). However, the resistance problem of treatment using the current drug in ALL patients has decreased the effectiveness of such therapy. Therefore, a study needs to be conducted to identify the potential of new anticancer agents. Organotin (IV) dithiocarbamate, an organometallic compound, causes toxic effects on cancer cells in … …OnLine Journal of Biological Sciences, Vol. 23, Issue 2 · 10 Mar 2023 · 5,159 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsLippia graveolens and Carya illinoensis Organic Extracts and there in vitro Effect Against Rhizoctonia Solani KuhnFrancisco Daniel Hernandez-Castillo, Francisco Castillo-Reyes, Gabriel Gallegos-Morales et al.Problem statement: Plant extracts with polyphenolic compounds obtained with different solvents have been evaluated against plant pathogens. However, most of these extract have been obtained using solvents no allowed under an organic production context. Approach: In the present research was to evaluate the inhibitory effect of polyphenolic extracts from L. graveolens and C. illinoensis, obtained with alternative organic solvents (lanolin … …American Journal of Agricultural and Biological Sciences, Vol. 5, Issue 3 · 30 Sep 2010 · 8,991 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEffects of a Cyclachaena Xanthiifolia Extract on Trematodes Opisthorchis Felineus: An in Vitro StudyDenis Ponomarev, Elena Khramova, Natalia Gubanova et al.Cyclachaena xanthiifolia is a phytochemically rich invasive weed with documented allelopathic properties, making it a candidate source of bioactive compounds with potential medicinal applications. This study investigated the anthelmintic activity of a crude aqueous-ethanolic extract of C. xanthiifolia (CxEt), prepared from equal proportions of leaves and seeds, against the trematode Opisthorchis felineus in vitro. The effects of CxEt on the … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 1 Jun 2026 · 1,251 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEffect of Methyl Jasmonate and Plant Growth Promoting Rhizobacteria (PGPR) on Antioxidant Potential and Metabolomic Profiles of Zingiberaceae RhizomesHenny Lieke Rampe, Hanny Hesky Pontororing, Hanry Jefry Lengkong et al.The rhizomes of Zingiberaceae plants are used as cooking spices, medicines, cosmetics and beverage ingredients. Zingiberaceae rhizomes have the potential to be immunostimulants, antioxidants and immunomodulators. Antioxidants are chemical compounds that bind free oxygen radicals and prevent free radicals from damaging healthy cells. This research aimed to analyze the antioxidant potential and metabolomic compounds of the rhizomes of the Zingiberaceae … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 10 Apr 2026 · 1,311 accessesView PDF Cite

Research ArticleOpen accessIn the abstractScreening of Bioactive Constituents from the Aerial Parts of Dictamnus dasycarpus Turcz. With Antioxidant, Immunoenhancing, and Anticoagulant PotentialJiaqi Sun, Shiyu Ji et al.The cultivation of Dictamnus dasycarpus Turcz (DdT) is expensive and difficulty associated with growing, making its root bark the only commonly used medicinal part, while other parts are discarded. Therefore, in order to improve the limited utilization of resources, the new medicinal parts were screened from polysaccharide-rich aqueous extracts. The samples were the purified polysaccharides from the aerial part on … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 9 Oct 2025 · 2,018 accessesView PDF Cite

Research ArticleOpen accessIn the abstractStudy of Ageratum conyzoides L. (Asteraceae) Phytochemical Composition as Quorum-sensing Inhibitors to Combat Antibiotic-resistant Bacterial InfectionsEli Compaoré, Lassané Ouedraogo, Ablassé Rouamba et al.The rise of antibiotic-resistant bacterial infections has intensified the search for plant-derived quorum-sensing (QS) inhibitors as alternative therapeutic strategies. Ageratum conyzoides L. has a long history of traditional use as an antimicrobial agent against multidrug-resistant pathogens, yet the phytochemical basis of its QS-inhibitory activity remains incompletely characterized. This study aimed to investigate the phytochemical composition of A. conyzoides and evaluate … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 3 Apr 2026 · 1,772 accessesView PDF Cite

Research ArticleOpen accessIn the abstractOptimization of Hydrodistillation Extraction by Response Surface Methodology and Evaluation of the Antioxidant and Antimicrobial Activities of Essential Oils from Phragmites communis (Cav) TrinXin-Tong Zou, Hong-Yuan Ma, Yu-He Li et al.The principal objectives of this study encompass three distinct aspects: firstly, to streamline the extraction process of Phragmites communis (Cav) Trin essential oil; secondly, to systematically analyze the essential oil’s chemical composition; and finally, to evaluate biological activity. Through the system optimization experiment, the optimal extraction process was determined: the crushing size was set to 10 mesh, the total solid-liquid … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 6 Jan 2026 · 2,315 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCytotoxicity and Apoptosis Prevailed by Tricyclohexyltin(IV) Dithiocarbamate Compounds Against Human Lung Carcinoma Cell Line (A549)Normah Awang, Nurul Amalina Abd Aziz, Nur Fatini Nordin, Nurul Farahana KamaludinIn Malaysia, lung cancer is a highly common kind of cancer and the leading cause of cancer-related deaths. This study examined the cytotoxicity of two new tricyclohexyltin(IV) dithiocarbamate compounds compounds, which are tricyclohexyltin(IV) N-methyl-N-benzyldithiocarbamate (C1) and tricyclohexyltin(IV) N-ethyl-N-benzyldithiocarbamate (C2), on lung carcinoma cell lines (A549) of humans. The cytotoxicity was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. Cell death mode … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 13 Jun 2024 · 4,622 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPhytochemical Composition, Antibacterial, and Antioxidant Properties of Foeniculum vulgare Essential OilSaif M. Dmour, Saqr Abushattal, Sultan Ayesh Mohammed Saghir et al.This study intended to inspect the phytochemical composition and bioactivity of Fennel (Foeniculum vulgare) Seed Essential Oil (FSEO) from Jordan. The EO was extracted via hydrodistillation from air-dried samples with 4.42% (v/w) yield. Twenty compounds, constituting around 98.5% of the EO were identified using Gas Chromatography-Mass Spectrometry (GC-MS). Estragole (47.15%) and Anethole (36.2%), appeared as predominant oxygenated monoterpenes compounds in … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 1 Aug 2025 · 4,638 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCultivation of Antioxidant-Producing Endophytic Fungus in Rhizophora apiculata Mangrove PlantsAnthoni Agustien, Putra Santoso, Siti Zaharani Zalamah et al.West Sumatra is known as one of the largest areas of mangrove forests in Indonesia, dominated by Rhizophora. Therefore, there will be huge opportunities to discover new types or strains of endophytes and antioxidant compounds, which play an important role in protecting cells caused by free radicals, preventing oxidation, and protecting the human body from ROS. This study aims to … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 4 Aug 2024 · 4,991 accessesView PDF Cite