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Research ArticleOpen accessEvery word in the titleWound Healing Activity of Chlorogenic Acid in Diabetic Rats is Mediated Through Antibacterial, Antioxidant, and Proliferative EffectsAbdullah Abdulrahman Al-Ghanayem, Mohammed Sanad Alhussaini, AbdulRahman Abdulla Ibrahim Alyahya et al.Chlorogenic acid is known to have antibacterial action against a number of pathogens. This study provides insights into the potentiality of chlorogenic acid in the treatment of chronic infection in wounds. The anti-infective and healing effect of chlorogenic acid in infected wounds was evaluated using diabetic rats. Antibacterial activity of chlorogenic acid against Methicillin-Resistant Staphylococcus Aureus (MRSA) and Multidrug-Resistant (MDR) … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 21 Jan 2024 · 6,154 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHepato and Nephrotoxicity Caused by Sub-Chronic Exposure to Relevant Concentrations of Human Exposure to Glyphosate-Based Herbicide: An Experimental Study in RatsFernanda de Maria Serra, Letícia Rocha Magalhães, Beatriz Bertholace Magalhães Silva et al.Glyphosate's remarkable effectiveness in weed control has made it among the foremost widely employed herbicides globally. Several Glyphosate-Based Herbicides (GBHs) contain 1-4 dioxane, a compound known to induce cancer in animals and potentially contribute to liver and kidney damage in humans. The objective was to assess the liver and kidney toxicity resulting from sub-chronic exposure to GBH in rats. Eighty … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 26 Dec 2023 · 5,194 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAlcohol Intubation and Synergistic Effect of Folic Acid and Egg Yolk Powder Solution on Alcohol Dehydrogenase [ADH] Class I Gene Expression and Single Nucleotide Polymorphism Frequency in Parent and Prenatal Alcohol Exposed Wistar RatsAdejoke Olukayode Obajuluwa, Oluyinka Ajibola Iyiola, Joseph Akintade Morakinyo et al.Point mutation detections in alcohol metabolizing genes could unravel molecular targets of gestational alcohol and epigenetic remodeling capacity of maternal nutrition, which underscores growth and health endpoints in Pre­natal Alcohol Exposed (PAE) fetuses. gene expression was assayed using sequenced target and internal control gene primers in a two-step thermal cycling process from isolated RNA in purely bred alcohol male and … …OnLine Journal of Biological Sciences, Vol. 24, Issue 1 · 22 Nov 2023 · 4,857 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleImpact of Coriander Seeds Extract Against Thyroidectomy Induced Testicular Damage and DNA Replication in Male RatsAzhar Azher Alankooshi, Ahmed F. Hasan et al.An important target organ for thyroid hormone activity is the testis and hypo or hyperthyroidism causes noticeable alterations in testicular function. This study aimed to investigate the therapeutic effect of Coriander Seeds Extract (CSE) against thyroidectomy induced toxicity, oxidative stress, injury, and proliferation in male testes rats. 40 male rats were equally divided into 4 groups [Gp1, control; Gp2, CSE; … …OnLine Journal of Biological Sciences, Vol. 23, Issue 2 · 3 Apr 2023 · 6,611 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleOrlistat Induce Renal Toxicity, DNA Damage, and Apoptosis in Normal and Obese Female RatsHaneen Mushtaq Hameed, Ahmed Flayyih Hasan, Zainab Haytham Razooki et al.Obesity has been linked to several chronic diseases, including fatty liver disease, fatty heart disease, diabetes mellitus, hypertension, obstructive sleep apnea, and cancer. The purpose of the current study was to determine how Orlistat affected renal toxicity, DNA damage, and apoptosis that were brought on by obesity in normal and obese female rats. There were four groups made up of … …OnLine Journal of Biological Sciences, Vol. 23, Issue 1 · 18 Jan 2023 · 5,831 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRole of the Wnt/β-Catenin Signaling Pathway in Reducing Lipogenesis of Obese Rats Under Hypoxic ExercisePeiming Xu, Zhiyuan Sun, Xiaoyi Tian et al.Hypoxic exercise exerts a significant effect on body weight loss and body fat reduction. Methods: In the present study, we constructed an obese rat model and divided rats into the following groups: Normoxic quiet (C), Hypoxic quiet (H), Normoxic Exercise (CE), and Hypoxic Exercise (HE). We employed isobaric tags for relative and absolute quantification (iTRAQ) using proteomic technology to screen … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 2 · 3 Jun 2022 · 5,737 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDifferent Arrangement of Dopamine Receptors/NMDA Receptors Heterocomplexes in the Brain Regions of a Healthy Male, Female and Audiogenic Seizure-Prone Male RatsGigi Tevzadze, Elene Zhuravliova, Natia Okriashvili et al.Differences in the composition and subcellular localization of heteroreceptors in the brain can trigger central nervous system diseases, including epilepsy and autism. Protein-protein interactions between Dopamine Receptors (DRs) and GLUN2A and GLUN2B subunits are critical mechanisms that regulate dopamine and glutamate coordinated signals. These interactions may be involved in the pathophysiological predisposition of epilepsy. We hypothesized that the specificity of … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 2 · 27 Apr 2022 · 6,098 accessesView PDFCite
Research ArticleOpen accessEvery word in the titlePreparation, Identification and Antioxidant Evaluation of Citrullus Colocynthis Root and Fruit Extracts Against Doxorubicin in Male RatsSarah Samir Othman, Gamal M. Hamad, Sabria Abo Zaid Hassan et al.Millions of people are affected by diseases in developing or developed countries. Citrullus colocynthis is a high-antioxidant wildflower, it is healthy to eat and may be used as a source of energy or medication. The goal of this research was to conduct a phytochemical analysis of Citrullus colocynthis fruit extract, which is abundant in Egypt. Different extracts from that plant … …OnLine Journal of Biological Sciences, Vol. 22, Issue 1 · 8 Feb 2022 · 6,243 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleProtective Role of Chichorium intybus Extract Against Renal Toxicity Induced by Magnetite Silver Nanoparticles in Male RatsDoha M. Beltagy, Ehab Tousson, Nabiha I Abdo, Batoul M. IzzularabMagnetite silver nanoparticles (Fe3O4/AgNPs) symbolize a new candidate in several industrial and biological products for their activities, simple preparation and low synthesis costs. Many studies recommended the usage of Fe3O4/AgNPs to overcome lacking biocompatibility of AgNPs inside the body. However, Fe3O4/AgNPs also has toxic effects on kidney tissues. In this study, AgNPs was synthesized on the surface of magnetic nanoparticles … …OnLine Journal of Biological Sciences, Vol. 21, Issue 3 · 15 Sep 2021 · 6,318 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleProtective Effect of Lactoferrin against Chromium Induced Adverse Renal Changes in Rats: Oxidative Stress TheoryMohammed H. Hassan, Dorreia Abd-Alla Mohamed Zaghloul, Marwa Ahmed Mahmoud et al.Among the toxic metals, chromium (Cr) which is a naturally occurring heavy metal commonly enters the environment through the effluents from various industries. Kidney disease is often cited as an adverse effect of chromium. We aimed to assess chromium-induced pathophysiological adverse renal damage and determine the potential protective effects of co-therapy with Lactoferrin (LF) in male albino rats. Forty male … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 2 · 28 Apr 2021 · 6,663 accessesView PDFCite