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Research ArticleOpen accessEvery word in the titleEvaluation of Acute Oral Toxicity Induced by Tablets Based on Ethanolic Extract of Salvia dumetorum Leaves in Experimental RatsYana Levaya, Karakoz Badekova, Mussa Zholdasbayev, Gayane AtazhanovaThe aim of this study was to assess the acute oral toxicity of a solid dosage form based on Salvia dumetorum Andrz. ex Besser leaf extract (SDT5) in experimental rats. Acute toxicity was evaluated over a 14-day observation period following a single oral administration at three dose levels (500 mg/kg, 1000 mg/kg, and 2000 mg/kg), prepared in 0.5 mL of … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 23 Jun 2026 · 1,241 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAluminium-Induced Hepatotoxicity and the Protective Role of Withania somnifera (Ashwagandha) in Wistar RatsAnchana Babu, Rekha D Kini, Nayanatara Arun Kumar, Megha GokulAluminium is a widely distributed environmental contaminant whose chronic exposure leads to accumulation in multiple organs, including the liver, resulting in oxidative stress and tissue damage. When reactive oxygen species production exceeds the body's antioxidant defense capacity, cellular injury ensues — a mechanism central to aluminium-induced hepatotoxicity. Withania somnifera (Ashwagandha), an evergreen herb of the Solanaceae family widely cultivated in … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 6 Apr 2026 · 1,449 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Long Term Cadmium Chloride Exposure on Testicular Functions in Male Albino RatsRania Abdel Rahman Elgawish, Mohamed Elshabrawy GhanemThis study was carried out to investigate the adverse effects of different doses of Cadmium Chloride (CdCl2) on reproductive functions in male rats. Forty male albino rats weighted 100-130 g were equally divided into 4 groups. The control group received distilled water throughout the experimental period, while the three treated groups received 5, 50 and 100 ppm of CdCl2 in … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 4 · 10 Dec 2014 · 8,302 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEFFECTS STUDY OF NIGELLA SATIVA, ITS OIL AND THEIR COMBINATION WITH VITAMIN E ON OXIDATIVE STRESS IN RATSAmr A. RezqAntioxidants or free radical scavengers are very important in protecting the living cells against any damage induced by free radicals. The effects of Nigella Sativa Extract (NSE), Nigella Sativa Oil (NSO) and Vitamin E (Vit. E) and the combination of NSE or NSO with Vit. E on potassium bromate (KBrO3)-induced oxidative stress in male rats were investigated. Forty nine Sprague … …American Journal of Applied Sciences, Vol. 11, Issue 7 · 23 Apr 2014 · 7,005 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIMPACT OF DEHYDROEPIANDROSTERONE IN PREVENTION OF PARACETAMOL INDUCED NEPHROTOXICITY IN RATSAbbas O. ElkaribParacetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. However, Dehydroepiandrosterone (DHEA), the major secretory product of the human adrenal gland, has been shown to possess a multi-targeted antioxidant activity which is also effective against lipid peroxidation induced in various animal models and against various human disorders. In this study, the … …Current Research in Medicine, Vol. 5, Issue 1 · 26 Mar 2014 · 7,566 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHEPATOTOXIC EFFECT OF ITRACONAZOLE IN EXPERIMENTAL RATSMohammed El-Hassan Abdelmaged KemeirItraconazole is a widely used antifungal drug. In situations such as managing patients with gastrointestinal basidiobolomycosis, third of which cases world-wide occur in the southwestern region of Saudi Arabia, prolonged treatment with this drug is required. Thus, this is study was designed to investigate the hepatotoxicity of long term administration of itraconazolein in Wistar rats. Two groups of rats were … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 1 · 30 Jan 2014 · 9,042 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Bisphenol a on Passive Avoidance Performance in Male RatsMahnaz Taherianfard, Bita Geramizadeh, Mehrzad Banihashemi et al.Bisphenol A (BPA) is used to manufacture polycarbonate plastic products in resins lining metal cans, in dental sealants and in blends with other types of plastic products. In sharp contrast, there are many published studies that BPA has a wide range of significant adverse effects including structural and neurochemical changes throughout the brain associated with behavioral changes, such as hyperactivity, … …Current Research in Medicine, Vol. 4, Issue 2 · 10 Dec 2013 · 7,222 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCombined Chelation Therapy with Deferasirox and Desferrioxamine In Removing Lead from RatsFaezeh Dahooee Balooch, Seyed Jamilaldin Fatemi, Marzieh Iranmanesh, Batool HosseinkhaniThe present study aimed to evaluate the potential efficiency of Deferasirox (DFX) and Desfferioxamine (DFO) as chelating agents in removing lead from rats as a biological model. Two different doses of lead (II) chloride (40 and 80 mg kg-1 body weight) were used for 45 days. After this period, all rats showed toxicity symptoms through loss of hair, greenish mottling … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 24 Sep 2013 · 7,151 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleNiacin Ameliorates Hypercalciuria and Hyperphosphaturia Due to Glucocorticoid Administration in RatsTahoora Shomali, Ali FakhrzadHypercalciuria and hyperphosphaturia are present in long term and high dose regimens of glucocorticoid therapy. This study aims to evaluate the effect of niacin at its pharmacological dose on calcium and phosphate disturbances due to methylprednisolone administration in growing rats. Twenty one rats were randomly divided into three equal groups and treated as follows for 4 weeks: 1-Normal saline (Control); … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 13 Jul 2013 · 7,404 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleProtective Effects of Propolis on Gamma-Irradiated Nigella sativa Extract Induced Blood and Immune Changes in Wistar RatsOsama Moseilhy Saleh, Mohamed Mohamed Soliman, Ahmed Abdel-Khalik Mansour, Omniya Mahmoud Abdel-HamidThe present study conducted to test the effect of Nigella Sativa (NS, 5 mg kg-1 of body weight), or γ-irradiated Nigella Sativa (GRNS) on the changes of blood component profiles, liver, kidney functions and immune cytokines secretion in male Wistar rats. Moreover, the possible protection by propolis (200 mg kg-1 B. W.) on the changes induced by NS and GRNS … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 2 · 20 Jun 2013 · 7,463 accessesView PDFCite