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Research ArticleOpen accessIn the abstractDihydroartemisinin Attenuates HBV-Induced Proliferation and Migration in LO2 cells via EMT Pathway ModulationYingde Nong, Caifang Ma, Wei Huang et al.Dihydroartemisinin (DHA), a derivative of artemisinin, possesses well-documented anti-inflammatory properties. This study investigated the inhibitory effects of DHA on hepatitis B virus (HBV)-induced cellular alterations in LO2 cells and elucidated underlying molecular mechanisms. Serum interleukin-6 (IL-6) levels were measured in HBV patients and analyzed for correlations with HBsAg, anti-HBs, and HBeAg. In vitro, LO2 cells were infected with clinical HBV … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 8 Jan 2026 · 2,071 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Atorvastatin on Oxidized Low-Density Lipoprotein-induced Proliferation, Apoptosis, and Matrix Metalloproteinase-9 Expression in Human MacrophagesBensheng Liu, Huifan Li, Yan Wang, Li ZhangAtorvastatin (ATV), an HMG-CoA reductase inhibitor, is utilized in the treatment of atherosclerotic diseases. Mononuclear Macrophages (MMs) are critical immune cells involved in atherosclerosis progression, participating in processes such as foam cell formation, cytokine secretion, and the development of fibrous cap and lipid core. To further elucidate the mechanism by which ATV exerts its therapeutic effects on atherosclerosis through the … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 18 Nov 2025 · 2,133 accessesView PDFCite
Research ArticleOpen accessIn the abstractCross Talk between Iron Regulatory Proteins and Proinflammatory Molecules in Ovarian Cancer Patients Based on Menopausal StatusHaritha Padannapurath Manoj, Sudha Kuthethur, Reshma Kumarchandra et al.Micronutrient iron is postulated to contribute to the initiation of cancer mainly by the formation of Reactive Oxygen Species (ROS), the key signaling molecules of inflammatory reactions. Iron may also cause elevation of MMP9, a gelatinase responsible for remodeling extracellular matrix in cancer cells through the ROS pathway. Estrogen the hormone which decreases markedly in post menopause is also known … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 31 May 2024 · 4,491 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Sled Dog Model for Positive Health Effects of Weight Management and ExerciseLaura Falkenstein, Scott Jerome et al.Obesity is a significant risk factor for metabolic syndrome and type II diabetes. Physical activity and/or dietary modification can reduce the incidence of obesity. Marginal fitness levels limit the efficacy of exercise training, and most humans choose from a wide range of dietary strategies to lose weight. Despite these limitations, exercise in the absence of weight loss may offer protective … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 1 · 23 Feb 2023 · 6,151 accessesView PDFCite
Literature ReviewOpen accessIn the abstractFundamental Questions about γδT CellsMoulay Yassine Belghali, Saadia Ba-M’hamed, Mouna Khouchani, Brahim AdmouγδT cells is a minor subgroup of T lymphocytes expressing γδ-T Cell Receptor (TCR), with many subsets, dominated by Vδ2 and Vδ1. γδT cells recognize antigens independently of the context of MHC class I, MHC class II, or CD1 presenting molecules. However, this recognition requires the expression of the transmembrane Butyrophilin proteins by the presenting cells. Their activation is controlled … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 15 Dec 2020 · 6,382 accessesView PDFCite
Research ArticleOpen accessIn the abstractClinical Significance of Precise Hyperthermic Intraperitoneal Chemotherapy Up-regulation RP11-356I2.2 Restraining the Occurrence and Development of Gastric CancerYu Yan, Feng Yanlin, Feng Jinxin et al.In order to study the therapeutic effect and possible mechanism of Precise Hyperthermic Intraperitoneal Chemotherapy (HIPEC) on gastric cancer, the expression of RP11-356I2.2 in gastric cancer cell lines and tissues was detected by real-time fluorescence quantitative PCR (RT-PCR). Chi-square test was used to analyze the correlation between the expression and clinic pathological parameters. Western blotting was used to detect the … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 2 · 4 Jun 2020 · 6,487 accessesView PDFCite
Review ArticleOpen accessIn the abstractMicroRNA-92a: The Administrator of Certain DiseasesZhiyuan Sun, Qing Xu, Xiaoyi Tian et al.MicroRNA-92a (miR-92a) is an evolutionarily conserved noncoding small RNA that can regulate gene expression after transcription. Previous studies have found that miR-92a is overexpressed in many tumors and can regulate numerous tumor suppressor genes negatively, with relevant effects on the development of different tumors, by regulating the DUSP10/c-Jun N-terminal kinase (JNK), phosphatase and tensin homologs (PTEN)/AKT, Wnt and EP4/Notch1 signaling … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 2 · 21 May 2020 · 6,494 accessesView PDFCite
EditorialOpen accessIn the abstractEditorial Commentary: Challenge of Non–AIDS-Defining Cancers (NADCs), Focusing on Trans Activation Response Element (TAR) RNA Embedding ExosomesLechuang Chen, Ge JinGlobally, 37.9 million people were living with HIV at the end of 2018 (Organization, 2018). Cancer is a major cause of mortality and morbidity in AIDS patients and chronically HIV-infected people. With the aid of combination Antiretroviral Therapy (ART), people living with HIV (PLWH) have a longer life span. However, because the virus is not completely eradicated, PLWH under antiretroviral … …American Journal of Immunology, Vol. 15, Issue 1 · 28 Nov 2019 · 6,657 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition Effect of Walnut Leaf Polysaccharide on HepG2 Cells in vitroShuqing Yang, Haifang Xiao, Shuyan Yu et al.In this study, the effect of Walnut Leaf Polysaccharides (WLP) on human liver tumor HepG2 cells was investigated. The results showed that WLP had dose-dependent and time-dependent inhibitory effects on HepG2 cell viability. Typical apoptosis characteristics were observed in WLP-treated HepG2 cells through 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-benzimidazolyl-carbocyanine iodide (DAPI) staining and Acridine Orange (AO)/Ethidium Bromide (EB) dual staining. Meanwhile, significant decrease in Mitochondrial … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 4 · 29 Oct 2019 · 7,313 accessesView PDFCite
Research ArticleOpen accessIn the abstractColor Doppler Evaluation of Isovolumetric Relaxation Time and of Signals Arising from Axons of the Median Nerve as a Means to Evaluate Mitochondrial Functionality in the Context of Immunotherapy of Cancer and Chronic Conditions Associated with Mitochondrial DysfunctionStefania Pacini, Marco RuggieroReactive Oxygen Species (ROS) arising from the disruption of mitochondrial respiration act as endogenous mutagens and tumor promoters. When production of ROS exceeds the capacity of DNA repair mechanisms, random mutations and aneuploidy ensue, thousands of genes become unbalanced and genetic/epigenetic chain reactions lead to progressive aneuploidy with only two outcomes: karyotypes so altered that are not viable or karyotypes … …American Journal of Immunology, Vol. 15, Issue 1 · 12 Oct 2019 · 9,690 accessesView PDFCite