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Research ArticleOpen accessPhrase in the titleThe Action of Bovine Cartilage on Tumor Cells In Vitro And In VivoArax Tanelian, Alexander M. AbdelnoorIn an earlier study we had investigated the effect of Bovine Cartilage (BC) on mouse melanoma cells. In pursuant to this study BC anti-tumor activity in vitro against several human tumor cell lines was evaluated, mechanism by which BC induces tumor cell death was studied and its immunogenicity was assessed. Five mice received Intraperitoneal (IP) injection of BC once every … …American Journal of Immunology, Vol. 14, Issue 1 · 23 Jan 2018 · 9,664 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleImatinib Mesylate Inhibits Glucose Uptake in Gastrointestinal Stromal Tumor Cells by Downregulation of the Glucose Transporters Recruitment to the Plasma MembraneHans Prenen, Cristiana Stefan, Bart Landuyt et al.Imatinib mesylate, the inhibitor of the KIT protein tyrosine kinase that is constitutively activated in Gastrointestinal Stromal Tumors (GISTs), has been established as the first highly effective drug in the treatment of patients with advanced GISTs. Recent studies suggest that changes in the glucose metabolism could be an additional mechanism of the anti-proliferative action of imatinib. The aim of this … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 7,245 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRADIOSENSITIZATION OF CANCER STEM CELLS: TARGETING TGFβ, NOTCH OR TELOMERASE TO IMPROVE TUMOR RESPONSE O RADIOTHERAPYIgnacio Fernandez-GarciaRadiation resistant cancer stem cells are the main reason for treatment failure and tumor recurrence after cancer radiotherapy. Increasing biological evidences demonstrate that these cells possess the capacity to repair radiation induced DNA damage, protect themselves from radiation derived reactive oxygen species, survive and proliferate after several fractions of radiotherapy and finally, repopulate the heterogeneity of the tumor. Thus, targeting … …Current Research in Medicine, Vol. 5, Issue 2 · 16 Jul 2014 · 7,459 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMast Cells Inhibit CD8+ T Cell-Mediated Rejection of a Malignant Fibrous Histiocytoma-Like Tumor: Involvement of Fas-Fas Ligand AxisHiroshi Furukawa, Hiroshi Kitazawa, Izumi Kaneko et al.Problem statement: Mast cells develop from bone marrow-derived progenitor cells and are distributed in the skin or mucosa where they play proinflammatory roles in the first line of defense. Since some tumors in humans and experimental animals exhibited infiltration of increased mast cells, we investigated the contribution of mast cells to the override of tumor rejection. Approach: MRL/N-1 cells are … …American Journal of Immunology, Vol. 5, Issue 3 · 30 Sep 2009 · 7,670 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Role of Treg Cells in the Cancer Immunological ResponseZhi-Zhang Yang, Stephen M. AnsellProblem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 8,518 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMonocytes and their Role in Human Immunodeficiency Virus PathogenesisTara Sassé, Jingqin Wu, Li Zhou, Nitin K. SaksenaMonocytes play several significant immunological roles during HIV infection. The phenotypic pliability and the cellular differentiation ability monocytes possess are crucial to the ways they combat infections and control inflammatory processes. The purpose of this review is to provide a comprehensive snapshot of the importance of monocytes in HIV-1 infection and pathogenesis. Moreover, this review also provides newly emerging data … …American Journal of Infectious Diseases, Vol. 8, Issue 2 · 31 Jul 2012 · 8,018 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEffect of Verapamil on Serum Level of Salinomycin in Diabetic RatsHossein Najafzadeh, Said Reza Fatemi, Amir AshnaProblem statement: The aim of present study was evaluation function of P-glycoprotein with or without verapamil in normal and diabetic rats; which the function of P-glycoprotein was indirectly evaluated by detection of serum slainomycin concentration with HPLC method. Approach: This study was carried in 4 groups of rats including normal rats which received salinomycin and verapamil together salinomycin; and diabetic … …American Journal of Applied Sciences, Vol. 8, Issue 9 · 1 Aug 2011 · 6,823 accessesView PDFCite
Research ArticleOpen accessIn the abstractBrain Tumor Segmentation and Classification Using HardNet Transformer With Gated Recurrent Unit ModelSaida D, Srinivas Adepu, Thade Lakshmi Devi et al.The uncontrolled growth of brain tumor cells presents a severe health risk, making early diagnosis and accurate classification essential for improving treatment outcomes. However, the existing approaches used for segmentation fail to delineate the tumor regions accurately due to a lack of global contextual information of brain tumors, resulting in poor classification performance. To overcome this limitation, this research proposes … …Journal of Computer Science, Vol. 22, Issue 9 · 26 Sep 2026 · 630 accessesView PDFCite
Research ArticleOpen accessIn the abstractDecoding Lung Cancer: PLAU as a Critical Driver and Diagnostic MarkerStanley Cho, Min Gyeong KimLung cancer remains a leading cause of cancer-related mortality, and understanding its underlying molecular mechanisms is critical for developing targeted therapies. We developed a novel tool called the Transcriptome-TCGA Integration (TTI), which combines in vitro transcriptome data with clinical datasets from the Cancer Genome Atlas (TCGA). TTI allows for the identification of key genes and pathways involved in lung cancer, … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,424 accessesView PDFCite
Research ArticleOpen accessIn the abstractTowards an Explainable Approach: Hybrid Residual Network and SVM for Automated Brain Tumor Detection and ClassificationKamini Lamba, Shalli RaniThe abnormal growth of brain cells leads to tumor formation, which can be fatal if not detected and treated promptly. Given the complexity of brain tumors, early detection is critical in healthcare. Traditional radiology-based tumor detection is prone to human error and delays. Hence, a computer- assisted method is needed for accurate and efficient diagnosis. With the rapid advancements in … …Journal of Computer Science, Vol. 22, Issue 1 · 11 Feb 2026 · 1,427 accessesView PDFCite