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25 results for “Cytotoxic Activity”
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Research ArticleOpen accessIn the abstractAnti-Proliferative Activity of Zerumbone Against Tumour Cell LinesAdel Sharaf Al-ZubairiZerumbone (ZER) is a cytotoxic phytochemical component extracted from the tropical herbal plant, Zingiber Zerumbet smith. It has been identified as an active anticancer compound. This study was aimed to evaluate in vitro the anti-proliferative activity of this bioactive compound, zerumbone, on seven cancer cell lines namely: CEMss (T4-lymphoplastoid), Chinese Hamster Ovary (CHO), 3T3 (mouse fibroblast), WEHI-3 (murine monomyelocytic leukemia), … …OnLine Journal of Biological Sciences, Vol. 18, Issue 2 · 25 Apr 2018 · 8,317 accessesView PDFCite
Research ArticleOpen accessIn the abstractBioactive Compounds from Sponge Associated Bacteria: Anticancer Activity and NRPS-PKS Gene Expression in Different Carbon SourcesJepri Agung Priyanto, Rika Indri Astuti, Jun Nomura, Aris Tri WahyudiSponge associated bacteria with diverse NRPS-PKS genes could be the alternative source of bioactive compounds. This study aimed to analyze the activity as well as the regulatory mechanism regarding the anticancer properties derived from these bacteria against cancer cell lines. Extraction of bacterial metabolites using ethyl acetate solvent resulted yield ranging from 0.003 to 0.016% (w/v). Six extracts of bacterial … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 4 · 5 Oct 2017 · 8,886 accessesView PDFCite
EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite
Research ArticleOpen accessIn the abstractBioactive Goniothalamin from Goniothalamus tapis with Cytotoxic PotentialKallaya Sangrueng, Saksri Sanyacharernkul, Sirinapa Nantapap et al.Goniothalamus (Annonaceae) is well known for the rich of styryllactone contents and these plants are famous for the potential to be applied as alternative biological activities. The chemical and biological investigations of Goniothalamus tapis is tested for anticancer activities. The research was processioned to extract, isolate, purify and elucidate structure from the leaves and twigs of G. tapis. The isolated … …American Journal of Applied Sciences, Vol. 12, Issue 9 · 4 Oct 2015 · 7,226 accessesView PDFCite
Research ArticleOpen accessIn the abstractBio-Guided Study on Melastoma malabathricum Linn Leaves and Elucidation of its Biological ActivitiesMourouge Saadi Alwash, Nazlina Ibrahim, Wan Yaacob AhmadThe present study aimed to isolate and identify constituents with antibacterial activity from the Methanol extract of Melastoma malabathricum leaves (MMML) through bioassay guided fractionation. Furthermore, the study scoped to evaluate the cytotoxic effects of M. malabathricum leaves fractions for possible protective effect of antoxidative constituents present in the fractions. The MMML extract was fractionated by Vacuum Liquid Chromatography (VLC) … …American Journal of Applied Sciences, Vol. 10, Issue 8 · 24 Jul 2013 · 9,513 accessesView PDFCite
Research ArticleOpen accessIn the abstractPhenolic Content, Antioxidant, Antimicrobial and Cytotoxic Activities of Ethanolic Extract of Salix albaGhassan Mohammad Sulaiman, Nehia Nima Hussien, Thorria Raddam Marzoog, Hussain Abood AwadThe total phenolic content, antioxidant, antimicrobial and cytotoxic activities of hot ethanolic extract of Salix alba bark were investigated. The antioxidant properties and the total phenolic contents of the extract were assessed by 1, 1-Diphenyl- 2-Picrylhydrazyl (DPPH) free radical scavenging and Folin-Ciocalteu methods, respectively. The extract showed significant antioxidant activity and antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa and Candida … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 1 · 18 Mar 2013 · 10,085 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntiproliferative Effects of Alkaloids Isolated from the Tuber of Stephania venosa via the Induction of Cell Cycle Arrest in Mammalian Cancer Cell LinesSirinapa Nantapap, Chatchanok Loetchutinat, Puttinan Meepowpan et al.Problem statement: S. venosa (Menispermaceae) is used in traditional medicine. The constituents of S. venosa belonging to showed remarkable cytotoxic activity. According to previous research, S. venosa contains several alkaloids, such as protoberberine stephanine cyclanoline and N-methylstepholidine, kamaline, (+)-N-carboxamidostepharine, (-)-O-methylstepharinosine, (-)-stepharinosine, aporphine (-)-O-acethylsukhodiamine and oxostephanosine. The chemical and biological investigations of this plant are interesting to bioassay-guided fractionation, particularly Antiproliferative … …American Journal of Applied Sciences, Vol. 7, Issue 8 · 31 Aug 2010 · 8,789 accessesView PDFCite
Research ArticleOpen accessIn the abstractSynthesis and Characterization of Organotin(IV) N-Benzyl-N-Isopropyldithiocarbamate Compounds: Cytotoxic Assay on Human Hepatocarcinoma Cells (HepG2)Normah Awang, Ibrahim Baba, Nor Syaidatul Akmal Mohd Yousof, Nurul Farahana KamaludinProblem statement: Several studies on organotin(IV) dithiocarbamate compounds have been carried out but not on the synthesis and characterization together with cytotoxic assay of organotin(IV) N-benzyl-N-isopropyldithiocarbamate compounds. Approach: Three new organotin(IV) compounds of type N-benzyl-N-isopropyldithiocarbamate have been successfully synthesized by direct reaction between secondary amine with organotin(IV) chloride using in situ method. All the compounds were characterized using elemental analysis, … …American Journal of Applied Sciences, Vol. 7, Issue 8 · 31 Aug 2010 · 8,092 accessesView PDFCite
Research ArticleOpen accessIn the abstractApoptosis of human Breast Cancer Cells induced by Ethylacetate Extracts of PropolisSyamsudin, Partomuan Simanjuntak, Ratna Djamil, Wan Lelly HeffenProblem statement: Propolis has been ethno medically claimed to possess a wide array of biological activities including anticancer activity. The purpose of this research was to verify the folklore claim. Approach: This study was performed in a human breast carcinoma cell, MCF-7. Extract of propolis from different solvent, ethylacetate and n-buthanol showed induced apoptotic cells was detected by flow cytometry. … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 11,587 accessesView PDFCite
Research ArticleOpen accessIn the abstractSynthesis and Characterization of Organotin(IV) Complexes Derived of 3-(Dimethylamino)benzoic Acid: Cytotoxic Assay on Human Liver Carcinoma Cells (HepG2)Yip-Foo Win, Siang-Guan Teoh, Tengku-Sifzizul Tengku-Muhammad et al.Problem statement: Many studies have been carried out on organotin(IV) complexes derivative of carboxylate anions. However, the synthesis and characterization as well as the cytotoxic assay of organotin(IV) carboxylate derived of 3-(dimethylamino)benzoic acid have not been studied. Approach: Organotin(IV) carboxylate complexes derivative of 3-(dimethylamino)benzoic acid, 3-[N(CH3)2]C6H4COOH have been successfully synthesized. Two types of diorganotin(IV) complexes, [{3-[N(CH3)2]C6H4COO(R)2Sn}2O]2 dimer (R = methyl … …American Journal of Applied Sciences, Vol. 7, Issue 3 · 31 Mar 2010 · 8,310 accessesView PDFCite