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74 articles for “Cardiovascular diseases”
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Research ArticleOpen accessIn the abstractsuPAR as an Inflammatory and Preclinical Atherosclerotic Marker in Hypovitaminosis DShravan Ajith Panchwadkar, Sudha Kuthethur, Neelam Manjunath Pawar et al.The mechanistic link between inflammation and atherosclerosis highlights the critical role of immune modulation in cardiovascular disease. The soluble urokinase plasminogen activator receptor (suPAR), an immune-derived factor, has recently emerged as a non-specific inflammatory marker across chronic diseases and infections. All cells within the atherosclerotic arterial wall can express uPAR and release urokinase, which plays a key role in the … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 30 Mar 2026 · 1,126 accessesView PDFCite
Research ArticleOpen accessIn the abstractAn Intelligent System for Cardiovascular Disease Prediction Using Deep LearningDeepika Arora, Deepak Dudeja, B K AgrawalHeart disease remains among the major causes of death in the world. Hence, accurate and reliable prediction schemes are key. To detect the presence of diseases in early stages, data mining and deep learning algorithms offer powerful tools to determine important trends in large and complex data. To enhance the prediction of cardiac diseases, this paper proposes a hybrid deep … …Journal of Computer Science, Vol. 22, Issue 2 · 9 Mar 2026 · 1,613 accessesView PDFCite
Literature ReviewOpen accessIn the abstractCorrelation of Atherosclerosis and Osteoarthritis, the Role of Inflammation in the Pathogenesis of Osteoarthritis and AtherosclerosisAnastasia V. Poznyak, Nikolay A. Orekhov, Aleksandra Sergeevna Utkina et al.Cardiovascular Diseases (CVD) rank among the leading causes of death globally, accounting for a substantial proportion of mortality rates and affecting millions of individuals. Risk factors such as ageing, obesity, diabetes and a sedentary lifestyle contribute significantly to the prevalence of CVD. Osteoarthritis (OA), on the other hand, is one of the most common joint disorders, affecting a large segment … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,777 accessesView PDFCite
Research ArticleOpen accessIn the abstractUPLC-Q-Exactive Orbitrap-MS Analysis of Anchusa italica Retz. Flowers: Molecular Docking, Dynamics Modeling, and Pharmacokinetics for Cardiovascular DiseaseLinyang Wang, Yan Chen, Ainiwaer Aikemu, Shuge TianThis study builds on prior UPLC-Q-Exactive Orbit rap-MS analyses of Anchusa italica Retz. Flowers (Airfs) to explore their anti-cardiovascular mechanis·ms and key bioactive markers. UPLC-Q-Exactive Orbitrap-MS identified 30 major compounds, including polyphenols and flavonoids with strong antioxidant activity. The potential active ingredients were then screened using Lipinski's rule of five, and a network pharmacology method was employed to construct an … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 25 Oct 2025 · 2,601 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Metaheuristic-Optimized Feature Selection for Early-Stage Diabetes Prediction With SHAP-Guided Insight into Influential AttributesEsmay Azam Rochy, Jannatul Ferdaus, Uzzal Biswas et al.Diabetes is a metabolic disorder that causes elevated blood glucose. This long-term health condition can lead to cardiovascular diseases, stroke, kidney failure, visual impairment, neuropathy, and even death in critical cases. So, a Computer-Aided Diagnostic (CAD) system is necessary to diagnose diabetes automatically. A clinician can utilize a machine learning-based CAD system that automatically diagnoses many people. This paper will … …Journal of Computer Science, Vol. 22, Issue 2 · 24 Feb 2026 · 1,744 accessesView PDFCite
Review ArticleOpen accessIn the abstractVLDL in Atherosclerosis: Variety of Mechanistic ImplicationsAnastasia Vladimirovna Poznyak, Victor Yurievich Glanz, Vasily Nikolaevich Sukhorukov et al.Very-Low-Density Lipoprotein (VLDL) particles play a pivotal role as precursors for Intermediate-Density Lipoprotein (IDL) and eventually transform into Low-Density Lipoprotein (LDL). These particles have been categorized based on size and particle charge. Various types of VLDL impact diverse physiological processes in the human body. The accumulation of VLDL, along with other triglyceride-rich lipoproteins, significantly contributes to the development of atherosclerotic … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 29 Jul 2024 · 4,314 accessesView PDFCite
Review ArticleOpen accessIn the abstractSIRT1 Controls Lipid Metabolism Under Physiological and Pathological Conditions: Implications in AtherosclerosisAnastasia Vladimirovna Poznyak, Ludmila Viktorovna Nedosugova, Victoria Alexandrovna Khotina et al.This comprehensive review examines the multifaceted role of Sirtuin 1 (SIRT1) in cellular metabolism and energy regulation, with a particular focus on its involvement in lipid metabolism and glucose regulation. Additionally, SIRT1's impact on several pathologies, including osteoarthritis, diabetes, and cardiovascular disease, is explored. Notably, this review sheds light on the unique contribution of SIRT1 in the development and progression … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 7 Jun 2024 · 4,743 accessesView PDFCite
Literature ReviewOpen accessIn the abstractAtherosclerosis as Age-Related Disease: The Potential of Sirtuins TreatmentAnastasia Vladimirovna Poznyak, Victor Yurievich Glanz, Vasily Nikolaevich Sukhorukov et al.Atherosclerosis, a global health concern, has attracted researchers worldwide due to its severe consequences. The elderly are particularly susceptible to cardiovascular diseases and events, making them a high-risk group. Although gaps in our understanding of atherosclerosis pathogenesis persist, it is evident that oxidative stress, endothelial dysfunction, inflammation, mitochondrial dysfunction, and autophagy impairments are key components of its development. Remarkably, these … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 16 May 2024 · 4,718 accessesView PDFCite
Review ArticleOpen accessIn the abstractOverview of Atherosclerotic Plaque: From Formation to ComplicationAnastasia Vladimirovna Poznyak, Varvara Alexandrovna Orekhova, Vasily Nikolaevich Sukhorukov et al.Atherosclerosis is a serious worldwide health problem. The pathogenesis of this disease is complex and includes a multilevel interaction of such processes as inflammation, endothelial dysfunction, mitochondrial dysfunction, and multiple modifications of lipid particles. With the increase in life expectancy, mankind is more and more often faced with the unpleasant consequences of atherosclerosis. Atherosclerosis is a precursor to serious health … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 6 Mar 2024 · 5,395 accessesView PDFCite
Review ArticleOpen accessIn the abstractUnveiling the Impact of Endogenous Sialidases on Human Non-Infectious Disease PathogenesisRaisa Sergeevna Surkova, Anastasia Vladimirovna Poznyak, Dmitry Alexandrovich Kashirskikh et al.In our review, we have compiled existing information regarding the role of endogenous sialidases (neuraminidases) in the initiation and development of various non-infectious processes in humans. Precisely, pathologies of the cardiovascular system, tumor formations, neurological and metabolic disorders, and hereditary diseases. Sialidases appeared to be widely involved in a variety of human pathologies. An increase or decrease in the enzymatic … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 10 Feb 2024 · 4,551 accessesView PDFCite