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44 articles for “Animal Models”
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EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite
Review ArticleOpen accessIn the abstractCirculating Immune Complexes as an Important Link between Inflammation and Lipid Alterations in AtherosclerosisAnastasia Vladimirovna Poznyak, Nikolay Alexandrovich Orekhov, Vasily Nikolaevich Sukhorukov et al.This review article rigorously investigates the emerging facets of atherosclerosis pathogenesis through an exhaustive examination of the existing data on the intricate interplay between lipid metabolism disorders and inflammation. A primary objective of this study is to thoroughly explore the role of Circulating Immune Complexes (CIC) as a pivotal indicator of this multifaceted interaction. The focus of this review centers … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 14 Aug 2024 · 3,926 accessesView PDFCite
Research ArticleOpen accessIn the abstractβ-Naphthalene Incorporated Thiazole-5-Carboxamides/Thiazole -5- Ketones: Design, Synthesis and Anticonvulsant Screening against Two Seizure ModelsMohammed Faiz Arshad, Faisal Al-Otaibi, Gulam Mustafa et al.A bunch of β-naphthalene incorporated thiazole-5-carboxamides/thiazole -5- ketones (7a-7o& 8a-8e) were prepared by reacting 4-methyl-2-(naphthalen-2-yl)thiazole-5-carbonyl chloride with appropriate amines. Structures of all the compounds were explained by elemental analysis, FT-IR, 1H NMR and mass spectral data. The compounds were evaluated for their anticonvulsant activity employing MES and chemoshock (scPTZ) seizure tests. Neurotoxicity was also assessed. Majority of these compounds exhibited … …American Journal of Pharmacology and Toxicology, Vol. 14, Issue 1 · 29 Aug 2019 · 7,494 accessesView PDFCite
Research ArticleOpen accessIn the abstractPreventive Effect of Marsileacrenata Leaves and Stalks Juices Against Urolithiasis Showed by Improving of Kidney FunctionSri MurwaniNowadays urolithiasisis still as a major problem in pet animals, particularly for dogs and cats. Urolithiasisis caused by formation of crystals in the urinary tract that inhibit the process of urination. It is frequently as an impact of dry food given regularly, keeping animals in a place so that the movement of the animal becomes restricted, lack of water intake, … …American Journal of Animal and Veterinary Sciences, Vol. 11, Issue 1 · 10 Feb 2016 · 9,305 accessesView PDFCite
Research ArticleOpen accessIn the abstractSpinal Cord Injury: Current Mammalian ModelsSarina Kundi, Roy Bicknell, Zubair AhmedIt is estimated that approximately 2.5 million people are affected by Spinal Cord Injury (SCI), with more than 130,000 new cases reported each year (International Campaign for Cures of Spinal Cord Injury Paralysis). Although there is currently no cure for SCI, various strategies including rehabilitative, cellular and molecular therapies have been tested in a variety of animal models. But questions … …Neuroscience International, Vol. 4, Issue 1 · 27 Mar 2013 · 14,041 accessesView PDFCite
Research ArticleOpen accessIn the abstractLagrangian Micromixing Models for Concentration Fluctuations: An OverviewPaolo Monti, Giovanni Leuzzi, Andrea AmicarelliThis study presents a brief overview of the main features, theoretical formulations and validation tests of some Lagrangian micromixing models, currently used for estimations of the ensemble mean and the turbulent fluctuations of concentration. Their application fields regards several pollutant dispersion phenomena such as: accidents (power or production plants, terroristic attacks, hydrocarbons storage and transport, extraordinary emissions), odours (power plants … …American Journal of Environmental Sciences, Vol. 8, Issue 6 · 28 Dec 2012 · 6,779 accessesView PDFCite
Research ArticleOpen accessIn the abstractUncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel MechanismClaudia Maturo, King C. Lee, Robert Rodriguez, Robert ShorrProblem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK) effects of CPI-613 in rats and to compare the toxicological profile of rats to minipigs to determine if there were differences between the two animal species. Approach: These studies involved assessments … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 9,582 accessesView PDFCite
Research ArticleOpen accessIn the abstractBotulinum Toxin as a Novel Addition to Anti-Arthritis ArmamentariumHamid Namazi, Zahra MajdOsteoarthritis is the most common joint disease and is among the most frequent health problems for middle aged and older people. There is strong evidence that proinflammatory cytokines contribute to cartilage degradation in osteoarthritis. Interleukin-1 is the prototypical proinflammatory cytokine implicated in the pathogenesis of cartilage matrix degeneration. Results from studies in animal models provide stronger evidence implicating a role … …American Journal of Immunology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,775 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Role of Living, Resident Bacterial Biofilm Populations in the Osseointegration of Oral ImplantsStephen Nelson, Honghua Hu et al.This study presents a human jawbone model which explains bone health, disease and quality and the osseointegration interphase, at the cell level. Curation of 454 pyrosequencing data obtained from 153 bone, serous-effusion and granulation samples taken from 40 patients during two-stage dental implant installation, revealed a 20 phyla jawbone microbiome with total genera of 387. Multivariate statistical ordination of curated … …Current Research in Dentistry, Vol. 14, Issue 1 · 16 Nov 2023 · 8,245 accessesView PDFCite
Review ArticleOpen accessIn the abstractPotential Effects of Adropin in Subarachnoid HemorrhageZahra Hasanpour Segherlou, Mohammad Reza Hosseini Siyanaki, Brandon Lucke-WoldSubarachnoid Hemorrhage (SAH) typically, occurs in patients over 55 years of age and can cause a significant loss of productivity. SAH also has a high mortality rate and those who survive often suffer from early and secondary brain injuries that can result from the condition. By gaining a better understanding of the pathophysiology of SAH, it may be possible to … …Neuroscience International, Vol. 13, Issue 1 · 21 Jul 2023 · 9,237 accessesView PDFCite