β-Naphthalene Incorporated Thiazole-5-Carboxamides/Thiazole -5- Ketones: Design, Synthesis and Anticonvulsant Screening against Two Seizure Models
Mohammed Faiz Arshad1, Faisal Al-Otaibi1, Gulam Mustafa1, Saad Shousha2 & Abdulrahman Alshahrani1 Show affiliations
- Shaqra University, Saudi Arabia
- Benha University, Egypt
American Journal of Pharmacology and Toxicology, Volume 14, Issue 1, pp. 27–37 · doi.org/10.3844/ajptsp.2019.27.37
Abstract
A bunch of β-naphthalene incorporated thiazole-5-carboxamides/thiazole -5- ketones (7a-7o& 8a-8e) were prepared by reacting 4-methyl-2-(naphthalen-2-yl)thiazole-5-carbonyl chloride with appropriate amines. Structures of all the compounds were explained by elemental analysis, FT-IR, 1H NMR and mass spectral data. The compounds were evaluated for their anticonvulsant activity employing MES and chemoshock (scPTZ) seizure tests. Neurotoxicity was also assessed. Majority of these compounds exhibited significant activity against both animal models; however, compounds 7e, 7j, 7n and 8c displayed promising activity and could be considered as leads for further investigations.
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Arshad, M. F., Al-Otaibi, F., Mustafa, G., Shousha, S. & Alshahrani, A. (2019). β-Naphthalene Incorporated Thiazole-5-Carboxamides/Thiazole -5- Ketones: Design, Synthesis and Anticonvulsant Screening against Two Seizure Models. American Journal of Pharmacology and Toxicology, 14(1), 27–37. https://doi.org/10.3844/ajptsp.2019.27.37
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