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11 results for “transforming growth factor-α”
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Research ArticleOpen accessEvery word in the titleTransforming Growth Factor-β: An Indirect Inducer of Th17 Cell Differentiation both in Human and Murine SystemJ. SchumannSince their first description only some years ago Th17 cells have become of vital importance in immunological research. However, the role of TGF-β in Th17 cell development is still a matter of controversial discussion. Predicted to have a key function in Th17 cell differentiation in the mouse TGF-β was shown to inhibit IL-17 production of human CD4+ T cells. Moreover, … …American Journal of Immunology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,575 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInternalizing Versus Non-internalizing Receptors for Targeting L-Methioninase to Cancer CellsXiao-Ping Zang, Naveen R. Palwai, J. T. Pento, Roger G. HarrisonWe reported previously that L-methioninase targeted to the urokinase receptor of MCF-7 breast cancer cells is significantly more effective in inhibiting cell proliferation and migration than free L-methioninase both in vitro and in vivo. L-methioninase was targeted by linking at its amino terminus to an amino-terminal fragment (ATF) of urokinase. The ATF was selected for targeting because is has previously … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,817 accessesView PDFCite
Review ArticleOpen accessIn the keywordsRole of Cytokines and Transcription Factors in Periodontitis: A Review of Cellular and Molecular MechanismsAnne Carolina Eleutério Leite, Valéria Martins de Araújo Carneiro, Júlia Faria Nunes et al.Periodontal Diseases (PD) are characterized by pathological manifestation of host immune response to bacterial infection at the tooth/gingival interface. Evidences points periodontitis as a risk factor for pathological systemic conditions, such as, cardiovascular diseases and diabetes. The identification of host factors that determine their susceptibility to immune subversion can provide useful information in the pathogenesis of periodontitis. Protective acute inflammatory … …American Journal of Immunology, Vol. 11, Issue 4 · 9 Dec 2015 · 7,807 accessesView PDFCite
Research ArticleOpen accessIn the keywordsSerum TGF-β and TNF-α During Psoriasis Therapy with Narrowband Ultraviolet BAhmad Taha Khalaf, Yan YuehuaAlthough it is now an accepted concept that narrow-band UVB therapy is an efficacious therapy for psoriasis, the relationship between the response rate and the potential effects on serum cytokines is less well-established. The purpose of this study was to investigate the correlation between the response rate and the changes of serum TGF-β and TNF-α necessary for understanding the underlying … …American Journal of Applied Sciences, Vol. 11, Issue 12 · 6 Jan 2015 · 6,088 accessesView PDFCite
Research ArticleOpen accessIn the keywordsProduction and Roles of Glial Tissue Inhibitor of Metalloproteinases-1 in Human Immunodeficiency Virus-1-Associated Dementia Neuroinflammation: A ReviewC. Chao, A. GhorpadeProblem statement: Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and its cognate targets, the Matrix Metalloproteinases (MMPs), were differentially expressed in human brain samples with or without HIV-1 infection or HIV-1 Encephalitis (HIVE). Approach: A through literature review demonstrated that cell culture models of Central Nervous System (CNS) cell types had been used to illustrate the intricate temporal patterns of TIMP-1/MMP expression, … …American Journal of Infectious Diseases, Vol. 5, Issue 4 · 31 Dec 2009 · 6,953 accessesView PDFCite
Review ArticleOpen accessIn the abstractGoats’ Litter Size Concerning Bone Morphogenetic Protein 15 Gene VariationsTebogo Letsukulo Percy Thepa, Thobela Louis Tyasi, Jones Ng’ambiBone morphogenetic protein 15 (BMP15), a member of the transforming growth factor-β (TGF-β) superfamily, plays essential roles in follicular development and ovulation. Single nucleotide polymorphisms (SNPs) in the BMP15 gene have been associated with litter size in multiple livestock species, yet no comprehensive systematic review has synthesized findings across goat breeds. This systematic review aimed to evaluate the association between … …American Journal of Animal and Veterinary Sciences, Vol. 20, Issue 4 · 18 Feb 2026 · 1,405 accessesView PDFCite
Research ArticleOpen accessIn the abstractWound Healing Activity of Chlorogenic Acid in Diabetic Rats is Mediated Through Antibacterial, Antioxidant, and Proliferative EffectsAbdullah Abdulrahman Al-Ghanayem, Mohammed Sanad Alhussaini, AbdulRahman Abdulla Ibrahim Alyahya et al.Chlorogenic acid is known to have antibacterial action against a number of pathogens. This study provides insights into the potentiality of chlorogenic acid in the treatment of chronic infection in wounds. The anti-infective and healing effect of chlorogenic acid in infected wounds was evaluated using diabetic rats. Antibacterial activity of chlorogenic acid against Methicillin-Resistant Staphylococcus Aureus (MRSA) and Multidrug-Resistant (MDR) … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 21 Jan 2024 · 6,154 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Progress of BMP4 on the Role of Ocular Development and Eye DiseasesLiang Jiaming, Wang Qian, Liu Xiaohe et al.Bone morphogenetic protein belongs to the transforming growth factor beta superfamily, is a unique ectopic cartilage and bone inducing activity of acidic protein. As one of the members of BMPs family, the formation and development of BMP4 in many organizations. In ocular tissue, BMP4 not only promotes the differentiation and development of different eye cells, but also plays an important … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 2 · 5 Apr 2017 · 7,686 accessesView PDFCite
Research ArticleOpen accessIn the abstractPossible Therapeutic Role of Jasonia Candicans and Jasonia Montana Extracts in the Regression of Alzheimer’s Disease in Experimental ModelHanaa H. Ahmed, Hoda F. Booles, Wagdy K.B. Khalil et al.The present article aimed to investigate the potential role of the ethanolic extracts of the aerial parts of Jasonia candicans and Jasonia montana in management of Alzheimer’s Disease (AD) in experimental model. Supplementation of drinking water AlCl3 (0.3%) for 16 weeks induced AD in male rats with siginifcant increase in brain Acetylcholinesterase (AchE) activity, Tumour Necrosis Factor (TNF-α), Transforming Growth … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 2 · 20 Jun 2013 · 7,830 accessesView PDFCite
Research ArticleOpen accessIn the abstractEconomic, Social and Political Scenarios of Mexico in the Next Two DecadesJosè G. Vargas-Hernàndez, Mohammad Reza NoruziProblem statement: This research proposal aims to analyze the economic, social and political foreseeable scenarios of Mexico by the year 2030. Approach: Starting from the analyzes of the recent economic, social and political developments, to searching the trends in specific economic issues such as international commerce, energy, employment, environmental constraints; social trends such as demographic transition, fertility, population growth, aging, … …Journal of Social Sciences, Vol. 5, Issue 4 · 31 Dec 2009 · 7,650 accessesView PDFCite