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Research ArticleOpen accessIn the keywordsβ-Naphthalene Incorporated Thiazole-5-Carboxamides/Thiazole -5- Ketones: Design, Synthesis and Anticonvulsant Screening against Two Seizure ModelsMohammed Faiz Arshad, Faisal Al-Otaibi, Gulam Mustafa et al.A bunch of β-naphthalene incorporated thiazole-5-carboxamides/thiazole -5- ketones (7a-7o& 8a-8e) were prepared by reacting 4-methyl-2-(naphthalen-2-yl)thiazole-5-carbonyl chloride with appropriate amines. Structures of all the compounds were explained by elemental analysis, FT-IR, 1H NMR and mass spectral data. The compounds were evaluated for their anticonvulsant activity employing MES and chemoshock (scPTZ) seizure tests. Neurotoxicity was also assessed. Majority of these compounds exhibited … …American Journal of Pharmacology and Toxicology, Vol. 14, Issue 1 · 29 Aug 2019 · 7,494 accessesView PDFCite