21 articles for “nucleic acid”

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Research ArticleOpen accessPhrase in the titleDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,506 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleThe Meaning of a Redundant Codon: There is Protein Folding Information in Nucleic Acids in Addition to the Genetic CodeJan C. Biro, Josephine M.K. BiroAll the information necessary for protein folding is supposed to be present in the amino acid sequence. It is still not possible to provide specific ab initio structure predictions by bioinformatical methods. It is suspected that additional folding information is present in protein coding nucleic acid sequences, which is not represented by the known genetic code. Nucleic acid subsequences comprising … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 1 · 31 Mar 2006 · 8,292 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleA Survey of Compute Intensive Algorithms for Ribo Nucleic Acids Structural DetectionRa’ed Al-Khatib, Rosni Abdullah, Nur’Aini Abdul RashidProblem statement: Finding an accurate RNA structural alignment from primary sequence due to it is time consuming and computationally NP-hard problem is a major bioinformatics challenge. According to our investigation majority of current researches were concerned on achieving faster execution time, improving space complexity and better cache management. Recently one research introduced cache-efficient Chip Multiprocessor (CMP) algorithms with good speed-up … …Journal of Computer Science, Vol. 5, Issue 10 · 31 Oct 2009 · 6,458 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsComparative Analysis of Various Diagnostic Methods for Trichomonas Vaginalis Infection in Trinidad and TobagoAruna Kumari Divakaruni, Bisram Mahabir, FA Orrett et al.Trichomonas vaginalis infection is a common sexually transmitted infection in the reproductive age group, which may lead to complications. Wet mount examination is the most common test for diagnosis, but it has low sensitivity. Fluorescent antibody staining can be used for diagnosis, but it is expensive and requires special microscopic facility. Culture is considered as the gold standard, but it … …American Journal of Infectious Diseases, Vol. 14, Issue 2 · 6 Oct 2018 · 8,057 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsStructural Analysis of DNA Interactions with Magnesium Ion Studied by Raman SpectroscopyS. Ponkumar, P. Duraisamy, N. IyanduraiProblem statement: In the present study, FT Raman spectroscopy had been used to extend our knowledge about Magnesium ion - DNA interactions at various volume ratios (1:50, 1:20, 1:10 and 1:5). Approach: The analysis of FT Raman data supported the existence of structural specificities in the interaction and also the stability of DNA secondary structure. Results: Results from the Raman … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 3 · 28 Nov 2011 · 8,679 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsAntibiotic Resistance of Community and Hospital Acquired Methicillin-Resistant Staphylococcus aureus Isolates from Clinical SpecimensAza Bahadeen Taha, Sabria M. Said Al-SalihiProblem statement: Methicillin-Resistant Staphylococcus aureus (MRSA) is responsible for an increasing number of serious hospital and community acquired infections. Increased emergence in MRSA resistance to antibiotics is a growing problem. Approach: The resistance of MRSA to 20 antibiotics agents were studied. Also comparison of antibiotics resistance of community and hospital acquired MRSA were performed. Meanwhile the profile of antibiotics resistance … …Current Research in Medicine, Vol. 2, Issue 2 · 4 Oct 2011 · 7,876 accessesView PDF Cite

EditorialOpen accessIn the abstractEditorial Commentary: Challenge of Non–AIDS-Defining Cancers (NADCs), Focusing on Trans Activation Response Element (TAR) RNA Embedding ExosomesLechuang Chen, Ge JinGlobally, 37.9 million people were living with HIV at the end of 2018 (Organization, 2018). Cancer is a major cause of mortality and morbidity in AIDS patients and chronically HIV-infected people. With the aid of combination Antiretroviral Therapy (ART), people living with HIV (PLWH) have a longer life span. However, because the virus is not completely eradicated, PLWH under antiretroviral … …American Journal of Immunology, Vol. 15, Issue 1 · 28 Nov 2019 · 6,657 accessesView PDF Cite

Research ArticleOpen accessIn the abstractImpact of Proven Viral Load on Common Cold Patients Treated with Pelargonium sidoides Preparation EPs 7630Tilman Keck, Andreas Strobl, Andreas Weinhaeusel, Berenike StrackeThe Common Cold (CC) is an acute respiratory tract disorder with viral etiology in at least 90% of the cases. Nevertheless, molecular diagnostic testing often confirms the presence of viral Nucleic Acids (NA) in only about half of the patients. Based on the results of a non-comparative, interventional multicenter study we compare the course of CC between patients with and … …American Journal of Infectious Diseases, Vol. 14, Issue 3 · 13 Nov 2018 · 8,402 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIn silico Analysis of 4CL Family in Scutellaria baicalensis through Biocomputational Tools and ServersGuoming Li, Xiaozhong Lan, Xiaorong Shui et al.The gene sequences of 4-coumarate:coenzyme A ligase (4CL) family of Scutellaria baicalensis came from the GenBank Database. With help of some bioinformatics tools such as Vector NTI Suite 8, ProtParam and SWISS-MODEL and so on, a series of biological information of their nucleic acid sequences and amino acid sequences were predicted and analyzed and the results were revealed as following: … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 1 · 15 Feb 2017 · 7,864 accessesView PDF Cite

Research ArticleOpen accessIn the abstractOne Can Slow Down the Aging through AntioxidantsRaffaella Aversa, Relly Victoria V. Petrescu, Antonio Apicella, Florian Ion T. PetrescuFree radicals are natural nanoparticles which are doing their part well defined in the human cell, but then they must be annihilated or eliminated to not destroy the cell or another part of our body. It has been shown that residual free radicals in the body are responsible for the aging. The role to annihilate them is ful-filled by the … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 4 · 8 Dec 2016 · 10,070 accessesView PDF Cite