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28 results for “nucleic acid”
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Research ArticleOpen accessPhrase in the titleDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,506 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleThe Meaning of a Redundant Codon: There is Protein Folding Information in Nucleic Acids in Addition to the Genetic CodeJan C. Biro, Josephine M.K. BiroAll the information necessary for protein folding is supposed to be present in the amino acid sequence. It is still not possible to provide specific ab initio structure predictions by bioinformatical methods. It is suspected that additional folding information is present in protein coding nucleic acid sequences, which is not represented by the known genetic code. Nucleic acid subsequences comprising … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 1 · 31 Mar 2006 · 8,292 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleA Survey of Compute Intensive Algorithms for Ribo Nucleic Acids Structural DetectionRa’ed Al-Khatib, Rosni Abdullah, Nur’Aini Abdul RashidProblem statement: Finding an accurate RNA structural alignment from primary sequence due to it is time consuming and computationally NP-hard problem is a major bioinformatics challenge. According to our investigation majority of current researches were concerned on achieving faster execution time, improving space complexity and better cache management. Recently one research introduced cache-efficient Chip Multiprocessor (CMP) algorithms with good speed-up … …Journal of Computer Science, Vol. 5, Issue 10 · 31 Oct 2009 · 6,458 accessesView PDFCite
Research ArticleOpen accessIn the keywordsComparative Analysis of Various Diagnostic Methods for Trichomonas Vaginalis Infection in Trinidad and TobagoAruna Kumari Divakaruni, Bisram Mahabir, FA Orrett et al.Trichomonas vaginalis infection is a common sexually transmitted infection in the reproductive age group, which may lead to complications. Wet mount examination is the most common test for diagnosis, but it has low sensitivity. Fluorescent antibody staining can be used for diagnosis, but it is expensive and requires special microscopic facility. Culture is considered as the gold standard, but it … …American Journal of Infectious Diseases, Vol. 14, Issue 2 · 6 Oct 2018 · 8,057 accessesView PDFCite
Research ArticleOpen accessIn the keywordsStructural Analysis of DNA Interactions with Magnesium Ion Studied by Raman SpectroscopyS. Ponkumar, P. Duraisamy, N. IyanduraiProblem statement: In the present study, FT Raman spectroscopy had been used to extend our knowledge about Magnesium ion - DNA interactions at various volume ratios (1:50, 1:20, 1:10 and 1:5). Approach: The analysis of FT Raman data supported the existence of structural specificities in the interaction and also the stability of DNA secondary structure. Results: Results from the Raman … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 3 · 28 Nov 2011 · 8,679 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAntibiotic Resistance of Community and Hospital Acquired Methicillin-Resistant Staphylococcus aureus Isolates from Clinical SpecimensAza Bahadeen Taha, Sabria M. Said Al-SalihiProblem statement: Methicillin-Resistant Staphylococcus aureus (MRSA) is responsible for an increasing number of serious hospital and community acquired infections. Increased emergence in MRSA resistance to antibiotics is a growing problem. Approach: The resistance of MRSA to 20 antibiotics agents were studied. Also comparison of antibiotics resistance of community and hospital acquired MRSA were performed. Meanwhile the profile of antibiotics resistance … …Current Research in Medicine, Vol. 2, Issue 2 · 4 Oct 2011 · 7,876 accessesView PDFCite