In silico Analysis of 4CL Family in Scutellaria baicalensis through Biocomputational Tools and Servers
Guoming Li1, Xiaozhong Lan2, Xiaorong Shui1, Shian Huang1, Can Chen1 & Wei Lei1 Show affiliations
- Guangdong Medical University, China
- Tibet Agricultural and Animal Husbandry College, China
American Journal of Biochemistry and Biotechnology, Volume 13, Issue 1, pp. 27–33 · doi.org/10.3844/ajbbsp.2017.27.33
Abstract
The gene sequences of 4-coumarate:coenzyme A ligase (4CL) family of Scutellaria baicalensis came from the GenBank Database. With help of some bioinformatics tools such as Vector NTI Suite 8, ProtParam and SWISS-MODEL and so on, a series of biological information of their nucleic acid sequences and amino acid sequences were predicted and analyzed and the results were revealed as following: Two 4cl member genes share high similarity in structure and properties on level of nucleic acid and amino acid molecular. 4CLs are hydrophic proteins without any transmembrane topological structure and some crucial motifs were found. The secondary structures of Sb4CLs are mainly composed of random coil and α-helix and the models of their tertiary structures were built. In silico analysis of Sv4CL was finished, which would pave for further studies of physichemical properties of 4CL family and its related molecular mechanism of flavonoid metabolic regulation.
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Li, G., Lan, X., Shui, X., Huang, S., Chen, C. & Lei, W. (2017). In silico Analysis of 4CL Family in Scutellaria baicalensis through Biocomputational Tools and Servers. American Journal of Biochemistry and Biotechnology, 13(1), 27–33. https://doi.org/10.3844/ajbbsp.2017.27.33
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