7 results for “mtDNA”

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Literature ReviewOpen accessEvery word in the titlePotential Therapies for Mitochondrial Diseases Caused by mtDNA MutationsAnastasia V. Poznyak, Nikolay A. Orekhov, Dmitry Felixovich Beloyartsev et al.Mitochondrial diseases, caused by mutations in mitochondrial DNA (mtDNA), present significant genetic and clinical complexities that challenge accurate diagnosis and treatment. This review examines the critical molecular mechanisms underlying these disorders, particularly the role of heteroplasmy, where mixtures of mutated and normal mtDNA influence disease severity, and the nuclear-mitochondrial DNA interactions that compound diagnostic and therapeutic challenges. The threshold effect, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,735 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsGenetic Characterization of Kazakh Native Sheep Breeds Using Mitochondrial DNAIlmira Mukhametzharova, Yessenbay Islamov, Saukymbek Shauyenov et al.In this study, we used mitochondrial (mt) DNA to reveal patterns of genetic diversity among six breeds of sheep native to Kazakhstan, including the Chu and Kalchengel types of Kazakh mutton-semifine-wool breed of sheep, Akzhayik, Edilbay, Kazakh fat-rumped semi-course-wool and South Kazakh Merino breeds. Mitochondrial DNA D-loop was studied in 64 samples to determine the genetic diversity of the local … …OnLine Journal of Biological Sciences, Vol. 18, Issue 3 · 7 Sep 2018 · 8,848 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsComparative Genomics of Domesticated and Wild Sunflower: Complete Chloroplast and Mitochondrial GenomesM. S. Makarenko, A. V. Usatov, N. V. Markin et al.The entire chloroplast and mitochondrial genomes of domesticated and wild type sunflower were sequenced. The comparative analysis of chloroplast genomes revealed 43 variant sites, including 21 polymorphic SSR loci and 22 SNPs. About 14 variant sites were found by collation of mitochondrial DNA (mtDNA), among them 4 SSRs, 8 SNPs and 2 deletions. About 9 SNPs were located in coding … …OnLine Journal of Biological Sciences, Vol. 16, Issue 1 · 29 Feb 2016 · 7,775 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsThe COXII Haplotypes and their Association with Productive Traits in Large White Breed PigsMaria A. Kolosova, Lyubov V. Getmantseva, Nekruz F. Bakoev et al.The mitochondrial genome encodes key electron transfer chain (ETC) proteins which produce the vast majority of cellular ATP. Sequence analysis of maternal inherited mitochondrial DNA is an effective way to assess the individual characteristics of commercial breeding lines of pigs. The aims of our study were to analyze the nucleotide sequence of the mitochondrial gene COXII in Large White pigs, … …OnLine Journal of Biological Sciences, Vol. 19, Issue 3 · 2 Jul 2019 · 7,655 accessesView PDF Cite

Research ArticleOpen accessIn the abstractForensic Relationship between ATP6 Gene and Sperm Motility in a Saudi PopulationSafa A.M. Elsanousi, Murid Javed, Hamad Sufyan, Sayed A.M. AmerApproximately 600 bp of ATP synthase subunit 6 mitochondrial gene (ATP6) were amplified and sequenced for 110 semen samples collected from infertile and normal Saudi men inhabiting Riyadh province. These data were analyzed in order to identify the Single Nucleotide Polymorphisms (SNPs) associated with male infertility. Six silent substitutions G8697A, G8856A, T8889C, T8952C, C9075T and C9060A were recorded with one … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 11 Jan 2020 · 7,617 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAge-Dependent Variation of Telomere Length and DNA Damage in ChickenMaxim S. Makarenko, Alexander V. Usatov, Lyubov V. Getmantseva et al.Birds are unique models for molecular studies on aging processes and cellular senescence because of their slow rates of aging and comparatively long life spans among homoeothermic animals. The study aimed to examine the relative telomere length and amount of nuclear, mitochondrial DNA lesions in hens of different ages and to find out the correlation between these biomarkers of aging. … …OnLine Journal of Biological Sciences, Vol. 17, Issue 4 · 14 Dec 2017 · 7,505 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPreliminary Study of Phylogenetic Relationship of Rice Field Chironomidae (Diptera) Inferred From DNA Sequences of Mitochondrial Cytochrome Oxidase Subunit ISalman A. Al-Shami, M.N. Siti Azizah, Che Salmah Md Rawi, Abu Hassan AhmadProblem statement: Chironomidae have been recorded in rice fields throughout the world including in many countries such as India, Australia and the USA. Although some studies provide the key to genera level and note the difficulty of identifying the larvae to species level. Chironomid researches have been hindered because of difficulties in specimen preparation, identification, morphology and literature. Systematics, phylogenetics … …American Journal of Applied Sciences, Vol. 6, Issue 5 · 31 May 2009 · 7,520 accessesView PDF Cite