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Research ArticleOpen accessIn the keywordsElevated Th17 and IL-23 in Hypertensive Patients with Acutly Increased Blood PressureJunxian Wang, Jianying Chen, Can Chen et al.Problem statement: Many severe cardiovascular complications such as stroke and heart attack can result from acutely increased blood pressure in patients with hypertension. The underlying mechanisms remain unclear despite of extensive study. To characterize the inflammatory mechanisms in hypertensive patients with acute blood pressure increase, we tested circulating Th17 levels, IL-23R expression and plasma levels of IL-17 and IL-23 in … …American Journal of Immunology, Vol. 8, Issue 2 · 21 May 2012 · 7,911 accessesView PDF Cite

Research ArticleOpen accessIn the abstractMRI Observation and Analysis of Muscle Activity During ExerciseLi-Chang Zou, Hong-Wu LiWhile conventional biomechanical testing techniques are able to determine the mechanical characteristics of muscle tissue, they do not offer precise insight into how muscle metabolism and microstructure change in response to various types of exercise activities over the course of time. Using Magnetic Resonance Imaging (MRI) analysis of muscle tissue allows researchers to examine how different levels of intensity affect … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 30 Jul 2026 · 1,025 accessesView PDF Cite

Research ArticleOpen accessIn the abstractBridging Innovation and Access: Randomized, Single-Dose, Open-Label, Parallel-Group Bioequivalence Study of Generic and Innovator Injection Semaglutide in IndiaMayur Madhav Mayabhate, Nitin Kapure, Akhilesh Sharma, Radhakrishna VaddemSemaglutide, a long-acting Glucagon-Like Peptide-1 (GLP-1) receptor agonist, is effective in improving glycemic control, reducing body weight, and lowering cardiovascular risk in Type 2 Diabetes Mellitus (T2DM). Limited accessibility of the innovator formulation underscores the need for bioequivalent generic alternatives. To assess the pharmacokinetic bioequivalence of a synthetic Semaglutide Injection (2 mg/1.5 mL) developed by Alkem Laboratories Ltd., India, compared … …American Journal of Pharmacology and Toxicology, Vol. 20, Issue 1 · 20 Apr 2026 · 2,626 accessesView PDF Cite

Research NotesOpen accessIn the abstractPre-Analytical Stability of Glycemia and Cholesterolemia in Serum Samples After Overnight Storage Under Controlled Freezing Conditions at -20°CSamia El Mahi, Asmae Tantane, Sanaa Ait HamouThe process of analysis comprised three phases: the pre-analytical, analytical, and post-analytical phases. Understanding the stability of biochemical analytes is of crucial importance. A study was conducted at the biochemistry and hematology laboratory in the National Institute of Hygiene in Rabat, Morocco. This study, that involved 160 individuals (both patients and healthy subjects), aimed to determine the stability of two … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 30 Sep 2025 · 2,581 accessesView PDF Cite

Research ArticleOpen accessIn the abstractFrequencies of the C1236T, G2677T/A, and C3435T Polymorphisms of the MDR1 Gene and their Haplotypes in UzbekistanS. B. Nurmatova, A. A. Abdurakhimov, O. S. Charishnikova et al.P-glycoprotein (P-gp) is encoded by the MDR1 gene and is involved in the pharmacokinetics of drugs. The best-known MDR1 gene polymorphisms are 1236C>T, 3435C>T, and 2677G>T/A, which are associated with protein folding, changes in mRNA levels, and drug pharmacokinetics. The aim of this study was to identify the frequency of distribution of functional polymorphisms C1236T, C3435T, G2677T/A of the MDR1 … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 5 Dec 2022 · 5,022 accessesView PDF Cite

Research ArticleOpen accessIn the abstractFrequency of Single Nucleotide Polymorphisms of the SLCO1B1 Gene in Slavic Population of Central EuropeMichaela Mikulová, Veronika Kramarova, Ján ChandogaThe organic anion transporting polypeptide 1B1 (encoded by SLCO1B1 gene) is involved in the active cellular influx of diverse endogenous compounds and several drugs, such as HMG-CoA reductase inhibitors (statins). Two common polymorphisms c.388A>G and c.521T>C in SLCO1B1 alter transport activity of this transporter and play an important role in the pharmaceutical response to many drugs. The aim of our … …OnLine Journal of Biological Sciences, Vol. 16, Issue 4 · 11 Dec 2016 · 7,308 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEfficacy Assessment of Kaempferia parviflora for the Management of Erectile DysfunctionPanakaporn Wannanon, Jintanaporn Wattanathorn, Terdthai Tong-Un et al.Age-related decline in erectile function is a noted phenomenon worldwide. A variety of medicinal plants have been identified as having strong aphrodisiac properties along with the ability to improve erectile functioning. Kaempferia Parviflora (KP) has famous as a Thai Viagra and use it to increase male impotency. However, there is limited scientific evidence regarding the efficacy of this herb on … …OnLine Journal of Biological Sciences, Vol. 12, Issue 4 · 4 Feb 2013 · 19,852 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRelationship between Fetuin-A and Systemic Lupus Erythematosus as a Predictor Marker for AtherosclerosisOsama F. Mosa, Ibrahim H. Mohamad, Magdi M. SalamaProblem statement: Associations between serum levels of fetuin-A, C3 complement, calcium × phosphate product and calcification risk index and lipid profile in SLE patients were established. However, the mechanism of accelerated atherosclerosis accompanied with SLE remains elusive. We therefore turned to investigate the association between Fetuin-A, disease activity and accelerated atherosclerosis in patients with SLE. Approach: Serum blood samples were … …Current Research in Medicine, Vol. 3, Issue 2 · 15 Sep 2012 · 7,777 accessesView PDF Cite

Research ArticleOpen accessIn the abstractComparative Analysis of UGT1A9 Genetic Polymorphisms between Chinese Han and Tibetan PopulationsWei Yan, Jian Cui, Yuewen Wang et al.Although various polymorphisms have been identified in the UGT1A9 gene in the main sorts of ethnic groups in the world, no investigations have been focused on the Chinese Tibetan populations and the comparison between Chinese Tibetan and Han populations to date. This study was designed to systematically compare genetic differences between the two populations. We investigated the functional regions of … …Current Research in Medicine, Vol. 3, Issue 2 · 23 Aug 2012 · 7,641 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRole of Progranulin Gene Expression as a Molecular Biomarker for Bladder CancerSalwa M. Abo El-khair, Mie A. Mohamed, Tamer E. AlkhiaryBladder cancer is the second most common cancer of the urinary system. Early diagnosis of this tumor and estimation of risk of future progression has a significant impact on prognosis. Although there are several molecular markers for the diagnosis and prognosis for this tumor, their accuracy is not ideal. Progranulin is a growth factor that may play a critical role … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 2 · 22 Jun 2012 · 7,699 accessesView PDF Cite