2 results for “endothelin-1”

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Research ArticleOpen accessIn the keywordsEndothelial Dysfunction Induced by Type 2 Diabetes Mellitus and Fibrinolytic ActivityHussein F. SakrProblem statement: Type 2 diabetes mellitus is the world's largest systemic and metabolic disease. Endothelin (ET) was first described as a peptidergic endothelium-derived constricting factor. Endothelin-1 is one of the endothelial factors that is overexpressed in cases of endothelial dysfunction. The fibrinolytic system is present in plasma with the degradation of fibrin polymers in blood clots. It is a proteolytic … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,729 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEndothelial Dysfunction and Insulin Resistance as Pathophysiologic Mechanisms in a Rat Model of PreeclampsiaAyman Z. Elsamanoudy, Amr M. AbbasProblem statement: To assess the plasma concentrations and placental gene expression of soluble fms like tyrosine kinase (sFlt-1), Vascular Endothelial Growth Factor (VEGF), visfatin and Tumour Necrosis Factor α (TNFα) in a rat model of preeclampsia, induced by chronic Reduction of Uterine Perfusion Pressure (RUPP) and to investigate the involvement of Insulin Resistance (IR) in the pathophysiology of preeclampsia and … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 7,503 accessesView PDF Cite