Author

Hussein F. Sakr

King Khalid University, Saudi Arabia

3 articles in our journals

Articles where this person is an author, newest first. People are matched by their name as printed (no ORCID iD is recorded for them), not by name alone; search the name as text to find namesakes too.

Research ArticleOpen accessQUERCETIN AMELIORATES DIABETIC NEPHROPATHY IN RATS VIA MODULATION OF RENAL NA+, K+-ATPASE EXPRESSION AND OXIDATIVE STRESSSalah O. Bashir, Mohamed Darwesh Morsy, Hussein F. Sakr et al.Diabetic Nephropathy (DN) is one of most prevalent complications of Diabetes Mellitus (DM), therefore prevention of its development is a important field for researches. Quercetin is a plant flavenoid with hypoglycemic and antioxidant properties that is claimed to have a reno-protective effect in diabetes. This study was designed to investigate the reno-preventive role of Quercetin treatment in terms of biochemical … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 14 Feb 2014 · 8,047 accessesView PDF Cite

Research ArticleOpen accessCardiac Depression Produced by L-Arginine and Phosphodiestrase Inhibitor on Isolated Mammalian Rabbit Heart: Function of Cyclic Guanosine Monophosphate (cGMP)Hussein F. Sakr, Fahaid Al-Hashem, Mahmoud Al-Khateeb et al.Problem statement: Cyclic guanosine 3',5'-monophosphate cGMP is one the important second messengers that determines the cardiomyocyte activity and its role in healthy and diseased cardiac muscle is still controversial. We are reporting the effect of adding L-arginine, the NO donor that stimulates cGMP production and Sildenafil citrate (phosphodiestrase inhibitor) that inhibits cGMP hydrolyis on isolated rabbit’s heart to answer: Is … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 8,182 accessesView PDF Cite

Research ArticleOpen accessEndothelial Dysfunction Induced by Type 2 Diabetes Mellitus and Fibrinolytic ActivityHussein F. SakrProblem statement: Type 2 diabetes mellitus is the world's largest systemic and metabolic disease. Endothelin (ET) was first described as a peptidergic endothelium-derived constricting factor. Endothelin-1 is one of the endothelial factors that is overexpressed in cases of endothelial dysfunction. The fibrinolytic system is present in plasma with the degradation of fibrin polymers in blood clots. It is a proteolytic … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,729 accessesView PDF Cite