16 results for “active sites”

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Research ArticleOpen accessPhrase in the titleIn silico Modeling of α1A-Adrenoceptor: Interaction of its Normal and Mutated Active Sites with Noradrenaline as well as its Agonist and AntagonistRamchandran Vijayan, Naidu Subbarao, Birendra Nath MallickNoradrenaline, like most other neurotransmitters, acts through various adrenoceptor subtypes. The structure and active site of adrenoceptors for the binding of noradrenaline were unknown, however, such information are crucial for understanding the molecular mechanism of action of neurotransmitters, including noradrenaline, in health and disease as well as for drug designing. In this in silico study, we modeled the α1A-adrenoceptor; a … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 7,140 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsUse of Enterobacterial Repetitive Intergenic Consensus PCR in Detecting Target(s) of Hapalindole-T, From a Cyanobacterium, in Escherichia Coli: In Silico ValidationManoj K. Tripathi, Maheep Kumar, Vinay K. Singh et al.Problem statement: Identification of newer biomolecule as well as targets are a rising concern because of increasing drug resistance in bacteria. We have isolated a broad spectrum antibiotic biomolecule Hapalindole-T from a cyanobacterium, Fisherella sp. growing on local Azadirachta indica tree bark. A model bacterium E. coli was screened spontaneously for Hap-T resistance. These resistant strains of E. coli were … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 3 Mar 2012 · 13,777 accessesView PDF Cite

Research ArticleOpen accessIn the abstractComputational Validation of Selected Compounds from the GC-MS Profile of Abies numidica Essential Oil and their Antibacterial EffectsAbdelouahab Dehimat, Boudjellal Fayssal, Salem Dounya et al.This work examined the chemical composition of the Algerian endemic tree Abies numidica (Pinaceae) and investigated the antibacterial potential of three major constituents of its essential oil-Santene, Linalyl acetate, and 2,6-Octadiene-2,6-dimethyl-as reported in previously published GC-MS data. Computational antibacterial screening was carried out by docking the selected compounds onto the bacterial proteins 5Z9N (Staphylococcus aureus) and 3AQC (Micrococcus luteus). Molecular … …Current Research in Bioinformatics, Vol. 10, Issue 1 · 24 Jan 2026 · 2,939 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCharacterization of the Electrical Energy Consumption of Some Areas Supplied by the Lomé a Interconnection Station of the CEET in Lomé, Togo: Analysis and DiscussionKrou Iparbè, Palanga Eyouléki Tcheyi Gnadi et al.This study aims to analyze the electricity consumption of Greater Lomé (Togo), a critical issue in view of the increasing needs and imperatives of energy transition. We used 63,943 data samples from the Togo Electric Energy Company (CEET), covering eight sites spread across three municipalities over a period of 84 months (2018-2024). A multidimensional statistical approach was used to evaluate … …American Journal of Engineering and Applied Sciences, Vol. 19, Issue 1 · 21 Jan 2026 · 3,384 accessesView PDF Cite

Research ArticleOpen accessIn the abstractMicro-Retargeted Advertising and Online Shoppers' Motivation in NigeriaJoseph Wilson, Yusuf Mu'azu, Fredrick WilsonOnline shopping is increasingly gaining popularity worldwide, as the experience is perceived not only to replicate but sometimes exceed that of traditional retail. The rapid transformation of the e-commerce sector compels online stores to adopt innovative strategies to attract and retain customers, enhance service delivery, increase product visibility, and remain competitive. The integration of big data and artificial intelligence has … …Journal of Social Sciences, Vol. 21, Issue 1 · 15 Aug 2025 · 5,437 accessesView PDF Cite

Research ArticleOpen accessIn the abstractTetrastigma hemsleyanum Diels et Gilg Roots from Different Origins: Pharmacognostical Identification, Content Determination of Functional Composition and in vitro Antioxidant ActivityGuang Mei Li, Jian Ge, Yongli Zheng et al.Tetrastigma hemsleyanum Diels et Gilg (T. hemsleyanum) is a unique and rare Chinese medicinal herb mainly distributed in the south of the Yangtze River in China. In the present study, T. hemsleyanum roots from seven different sites in the south of the Yangtze River (Guangxi [Baise, Guilin, and Hechi], Hunan [Fenghuang], and Zhejiang [Hangzhou, Taizhou, and Wenzhou] provinces) were collected, … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 1 · 23 Feb 2023 · 5,722 accessesView PDF Cite

Research ArticleOpen accessIn the abstractComputer Aid Screening for Potential Antimalarial Choroquinone Compounds as Covid 19 Utilizing Computational Calculations and Molecular Docking StudyAsmaa Aboelnaga, Asmaa M. Fahim, Taghreed H. EL-SayedClick reaction of 4,7-dichloroquinoline (1) with thiosemicarbazide (2) to afford the corresponding 2-(7-chloroquinolin-4-yl)thiosemicarbazide (3) utilized ultrasonic irradiation which can cyclized easily with ethylacetoacetate to give the 3-(7-chloroquinolin-4-ylamino)-tetrahydro-6-methyl-2-thioxopyrimidin-4(1H)-one (4) via nucleophilic substitution reaction. The synthesized compounds was examined in vitro antimalarial activity with IC50 = 11.92, 25.37 μg/mL against chloroquinone drug. Furthermore, the theoretical investigation of most active compounds CQT and … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 30 Nov 2020 · 6,568 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAir Quality Measurement at the Solid Waste Disposal of Matuail Landfill Site at Dhaka, BangladeshMd. Faruque Hossain, ASM Maksud Kamal, Abdul Halim Farhad Sikder, Zakia ParveenAn investigation was conducted to assess the air quality impact and possible health risk of solid waste disposal on surrounding environment of Matuail landfill site in Dhaka city. Three different locations were selected for soil and plant samples. Leachate samples were collected from active dumping area and fish samples from treated leachate pond. Seven different locations were selected for air … …American Journal of Environmental Sciences, Vol. 15, Issue 5 · 31 Oct 2019 · 8,348 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPrediction and Remediation of Water Quality in Monitoring Potential of Acid Mine DrainageNur Athirah Mohamad Basir, Wan Zuhairi Wan Yaacob, Nuur Hani Mohammed et al.Acid Mine Drainage (AMD) associated with both active and abandoned mining operations related to sulfide minerals, oxidation of pyrite affording an acidic solution that contains toxic metal ions. Result shows that pH value of water in Kg. Aur, Chini and Sg. Lembing are acidic with value of 2.81, 4.16 and 3.60 respectively. Maximum concentrations of heavy metals in the study … …American Journal of Engineering and Applied Sciences, Vol. 12, Issue 2 · 24 May 2019 · 7,011 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPollution Potential Assessment of Nymphaea alba in Nigeen Basin of Dal Lake, Kashmir (J&K), IndiaHina Mushtaq, Shameem Ahmad Shameem, Mumtaz Mohd Bhat et al.The present study was conducted to investigate the biochemical attributes of Nymphaea alba (also known as the European White Water lily or Nenuphar), an annual or perennial aquatic flowering plant at three study sites viz., site I (Nagoo Mohalla, near residential area); site II (Ashaibagh-adjacent to floating gardens) and site III (Marzibagh-Nigeen boat club) in Nigeen Basin of Dal Lake, … …American Journal of Environmental Sciences, Vol. 14, Issue 2 · 8 May 2018 · 8,807 accessesView PDF Cite