25 results for “SNPs”

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Research ArticleOpen accessEvery word in the titleForensic Evidence for Cytochrome b Gene SNPs in Obese and Non Obese Saudi ArabiansSayed Amin Mohamed Amer, Bandar Raddat Allah AlHothali, Monira Hmoud Alotaibi, Salah Mohamed TubaigyOral swabs from obese and non obese Saudi Arabians from both sexes with an average age of 35 years old were collected and their DNAs were extracted. PCR for 1000 bp of the mitochondrial cytochrome b (cytb) gene was conducted and the amplified products were sequenced in order to determine the possible forensic or obesity-related SNPs. Alignment of the obtained … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 1 · 9 Mar 2018 · 9,380 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleMinimum Free Energy Based Evaluation of mRNAs Secondary Structures Constructed by 18 Clinically Significant Exonic Single Nucleotide Polymorphisms (SNPs) and Haplotypes of 5 Missense SNPs of RB1 GeneSarder Nasir Uddin, Apurba Majumder, Khandker Khaldun Islam et al.Clinically significant 18 Single Nucleotide Polymorphisms (SNPs) from exon regions of Retinoblastoma gene (RB1) were analyzed to find out the structural variations in mRNAs. Online bioinformatic tools i.e., Vienna RNA, RNAfold were used for secondary structure analysis of mRNAs. Predicted minimum Free Energy Change (MFE) was calculated for mRNAs structures. It has been observed that the average of predicted MFE … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 4 · 21 Oct 2015 · 8,556 accessesView PDF Cite

Review ArticleOpen accessIn the keywordsVascular Endothelial Growth Factor: An Overview Across Multiple Disease ConditionsMiriam CanaveseVascular Endothelial Growth Factor (VEGF) is the major player in the regulation of physiological angiogenesis as well as it has also been implicated in pathological angiogenesis, associated with cancers and other conditions, among which psoriasis, autoimmune diseases and visual loss in macular degeneration. Interestingly, three regulatory Single Nucleotide Polymorphisms (rSNPs) in the promoter region of VEGF-A gene have been significantly … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 1 · 6 May 2015 · 7,099 accessesView PDF Cite

Review ArticleOpen accessIn the abstractGoats’ Litter Size Concerning Bone Morphogenetic Protein 15 Gene VariationsTebogo Letsukulo Percy Thepa, Thobela Louis Tyasi, Jones Ng’ambiBone morphogenetic protein 15 (BMP15), a member of the transforming growth factor-β (TGF-β) superfamily, plays essential roles in follicular development and ovulation. Single nucleotide polymorphisms (SNPs) in the BMP15 gene have been associated with litter size in multiple livestock species, yet no comprehensive systematic review has synthesized findings across goat breeds. This systematic review aimed to evaluate the association between … …American Journal of Animal and Veterinary Sciences, Vol. 20, Issue 4 · 18 Feb 2026 · 1,405 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRandom Forest-Based Genome Analysis for Disease Association and SNP Marker IdentificationXiangdong LiuAt present, genomic data analysis has the problems of insufficient model interpretation and limited computational efficiency in disease association research. As a powerful machine learning algorithm, Random Forest has demonstrated excellent ability in processing complex and multi-dimensional data sets and has gradually become a popular tool in the field of bioinformatics. The purpose of this paper is to explore how … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 25 Jul 2025 · 5,533 accessesView PDF Cite

Research ArticleOpen accessIn the abstractGenome-Wide Association Study of Single Nucleotide Polymorphisms with Milk Traits in Red Gorbatov CattleMarina Ivanovna Selionova, Grigorii Sergeyevich Shekhovtsev, Ivan Petrovich Prokhorov et al.In order to preserve the gene pool of the Red Gorbatov breed, it is necessary to use a set of genomic analysis tools that allows more efficient planning in obtaining individuals who meet the economic requirements of dairy farming. The aim of the work was to identify candidate genes associated with milk production traits in Red Gorbatov cattle using a … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 4 · 12 Oct 2024 · 4,736 accessesView PDF Cite

Literature ReviewOpen accessIn the abstractSystematic Review of Single Nucleotide Polymorphisms of Cattle Beta-Lactoglobulin Gene and their Association with Milk Production TraitsThlarihani Cynthia Makamu, Thobela Louis TyasiThe application of molecular genetics technology to pinpoint certain DNA markers associated with commercially significant features is highly anticipated since it has the potential to enhance the effectiveness of breeding programs by selecting young animals early for use as future breeding stock. One of the main genes expressed in bovine milk is the Beta-Lactoglobulin Gene (βLG), and its polymorphism can … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 2 · 4 Mar 2024 · 5,811 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAlcohol Intubation and Synergistic Effect of Folic Acid and Egg Yolk Powder Solution on Alcohol Dehydrogenase [ADH] Class I Gene Expression and Single Nucleotide Polymorphism Frequency in Parent and Prenatal Alcohol Exposed Wistar RatsAdejoke Olukayode Obajuluwa, Oluyinka Ajibola Iyiola, Joseph Akintade Morakinyo et al.Point mutation detections in alcohol metabolizing genes could unravel molecular targets of gestational alcohol and epigenetic remodeling capacity of maternal nutrition, which underscores growth and health endpoints in Prenatal Alcohol Exposed (PAE) fetuses. gene expression was assayed using sequenced target and internal control gene primers in a two-step thermal cycling process from isolated RNA in purely bred alcohol male and … …OnLine Journal of Biological Sciences, Vol. 24, Issue 1 · 22 Nov 2023 · 4,857 accessesView PDF Cite

Research ArticleOpen accessIn the abstractFrequencies of the C1236T, G2677T/A, and C3435T Polymorphisms of the MDR1 Gene and their Haplotypes in UzbekistanS. B. Nurmatova, A. A. Abdurakhimov, O. S. Charishnikova et al.P-glycoprotein (P-gp) is encoded by the MDR1 gene and is involved in the pharmacokinetics of drugs. The best-known MDR1 gene polymorphisms are 1236C>T, 3435C>T, and 2677G>T/A, which are associated with protein folding, changes in mRNA levels, and drug pharmacokinetics. The aim of this study was to identify the frequency of distribution of functional polymorphisms C1236T, C3435T, G2677T/A of the MDR1 … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 5 Dec 2022 · 5,022 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Relevance of Bioinformatic Tools in the Study of Polymorphisms of the B4GALNT2 Gene and its Association with CancerEddaikra Atika, Haddouche Hayet, Touil-Boukoffa ChafiaThe human gene B4GALNT2 encodes an enzyme (β1,4-N-acetylgalactosaminyltransferase II) that controls the expression of the blood group Sda carbohydrate’s antigen. This gene is located in position 17q21,32 and consists of 11 exons. The characterization and understanding of genetic variation is a real challenge in human genetics, both for healthy individuals and diseased ones. The in silico study of the B4GALNT2 … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 6,767 accessesView PDF Cite