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Research ArticleOpen accessPhrase in the titleComputational Prediction of Diabetic Nephropathy-Associated Comorbidities and Their Key Genes by Analyzing RNA-Seq DataChaity Paul, Md. Ashiq Uddin, Rupa Dey et al.Diabetic Nephropathy (DN) is a complex health condition that leads to various kidney diseases. According to the World Health Organization, over 2 million deaths have been reported due to diabetes and diabetes related kidney diseases in 2021. And at the recent 78th World Health Assembly, chronic kidney disease was reported to be one of the most common diabetes-related complications, and … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 19 May 2026 · 1,667 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIdentification of Long Non-coding RNAs Expressed During Early AdipogenesisRongkun Shen, Rachel A. Soeder, Henry D. Ophardt et al.Long non-coding RNAs (lncRNAs) are transcripts with a length of more than 200 nucleotides that lack protein-coding capacity. LncRNAs play important roles in the regulation of genes during many biological processes, development and disease progression, such as obesity. Obesity is an increasing health concern around the world. Although multiple studies linking lncRNAs and fully differentiated adipocytes have been published, the … …OnLine Journal of Biological Sciences, Vol. 19, Issue 4 · 30 Nov 2019 · 7,823 accessesView PDFCite
Research ArticleOpen accessIn the keywordsApplication of RNA-DNA Duplex Base Triplets to Antisense DrugsJie Yang, Yao Leng, Ju BaoSixty-four sets of three-dimensional models of RNA-DNA duplex base triplets were constructed based on codons by homology modeling method using software InsightII on Indigo workstation, which should be helpful for the study of RNA-DNA annealing, the basis of nucleic acids interactions and some peculiar motifs for design antisense oligonucleotides. Our research result reveal that the energies (such as E, Ec, … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,531 accessesView PDFCite
Review ArticleOpen accessIn the abstractSalt Tolerance and Cultivation Challenges of Jojoba (Simmondsia chinensis): A ReviewHeba Allah Adel MohassebJojoba is considered to be salt tolerant, but little is known about the extent of its tolerance and the relative influence on ion uptake and ethylene production and other factors are affecting the mode of actions of jojoba salt tolerant. According to many research has done before including our article about the glyoxalase I gene from jojoba which exhibits moderate … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 12 Jun 2025 · 3,314 accessesView PDFCite
Research ArticleOpen accessIn the abstractBiomolecular Identification of Bacteria Endophytic From Betel Leaf in Jambi City Forest Park Area as Antibiotic-Producing PotentialArzita, Miranti Sari Fitriani, Nyimas Myrna Elsa Fathia et al.Background and Objective: Muhammad Sabki City Forest Park in Jambi City has three types of betel plants that contain endophytic bacteria. In 2021, six isolates of endophytic bacteria with the potential for producing antibiotics (halo zone above 10 mm) have been isolated, which can kill Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) test bacteria. that are 5 (five) isolates derived … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,234 accessesView PDFCite
Research ArticleOpen accessIn the abstractGenetic Diversity of Leifsonia xyli Subsp. xyli Causing Ratoon Stunting Diseases of Sugarcane in Indonesia Using Intergenic Spacer Region Sequence AnalysisSisca Prayudani Usman, Abdul Latief Abadi et al.Leifsonia xyli subsp xyli (Lxx) is the cause of Ratoon Stunting Disease (RSD) on sugarcane and it considers as a quarantine pest in certain regions of Indonesia. RSD is a systemic disease that causes severe cane yield loss. Information about genetic diversity of this bacterial pathogen in Indonesia is limited. While global trading of sugar cane seed may facilitate the … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 23 Jun 2025 · 3,351 accessesView PDFCite
Research ArticleOpen accessIn the abstractTranscriptomic Analysis of the Erythritol High-Yielding Mutant Strain Yarrowia lipolytica Y44Xiaojie Ren, Heng Ban, Chao Huang et al.RNA-seq technique was used to analyze the transcriptomics of Yarrowia lipolytica control strain Po1g, an erythritol-producing natural isolate Yarrowia lipolytica Y 22 and an erythritol high-yielding mutant strain Y44 derived from Y 22. Functional annotation of genes and classification of metabolic pathways were carried out to identify Differentially Expressed Genes (DEGs). These DEGs were classified into related metabolic pathways to … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 4 · 20 Dec 2021 · 6,115 accessesView PDFCite
Research ArticleOpen accessIn the abstractAlcohol Intubation and Synergistic Effect of Folic Acid and Egg Yolk Powder Solution on Alcohol Dehydrogenase [ADH] Class I Gene Expression and Single Nucleotide Polymorphism Frequency in Parent and Prenatal Alcohol Exposed Wistar RatsAdejoke Olukayode Obajuluwa, Oluyinka Ajibola Iyiola, Joseph Akintade Morakinyo et al.Point mutation detections in alcohol metabolizing genes could unravel molecular targets of gestational alcohol and epigenetic remodeling capacity of maternal nutrition, which underscores growth and health endpoints in Pre­natal Alcohol Exposed (PAE) fetuses. gene expression was assayed using sequenced target and internal control gene primers in a two-step thermal cycling process from isolated RNA in purely bred alcohol male and … …OnLine Journal of Biological Sciences, Vol. 24, Issue 1 · 22 Nov 2023 · 4,857 accessesView PDFCite
Research ArticleOpen accessIn the abstractUPLC-QTOF-MS/MS and Bioinformatics Association Analysis Reveals the Pharmacodynamic Flavonoids in Scutellaria barbata and the Underlying Anti-Colorectal Cancer MechanismYi-Jie Cheng, Xin-Yun Du et al.Colorectal Cancer (CRC) is one of the most common and deadly malignancies worldwide, with no safe and effective drugs. The flavonoid in Scutellaria Barbata D. Don (SB) showed a good therapeutic effect on CRC. However, the pharmacodynamic substances and underlying mechanisms have not been elucidated which limited its development and application. This study aimed to identify the main flavonoid in … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 4 · 14 Nov 2023 · 5,398 accessesView PDFCite
Review ArticleOpen accessIn the abstractCOVID-19: A Review of Current Evidence on Phylogenetics and EtiopathogenesisRafiq Shajahan, Naganathan K. PillaiCOVID-19 represents the latest pandemic caused by the SARS-CoV-2 coronavirus. Coronaviruses are RNA viruses that cause a largely viral mediated immune-related syndrome similar to the SARS epidemic. Following metagenomic sequencing, SARS-CoV-2 closely resembles SARS-CoV (79% similarity) and MERS-CoV virus (50% similarity). Despite this, clinical observations have found varying degrees of infectivity and pathogenesis amongst these viruses. Phylogenetic origins of SARS-CoV-2 … …American Journal of Infectious Diseases, Vol. 17, Issue 1 · 2 Apr 2021 · 6,764 accessesView PDFCite