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8 results for “Phase I/II Integrated Design”
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Research ArticleOpen accessEvery word in the titleATLCEP: A New Integrated Design that Encompasses the Safety and Efficacy Objectives of Phase I/II TrialsRevathi Ananthakrishnan, Stephanie Green, Mark Chang et al.Several designs, such as designs to find the optimal biological dose, the Eff-Tox design and seamless Phase I/II designs, have been proposed to evaluate both drug toxicity and efficacy as alternatives to the traditional paradigm of a stepwise drug development approach. Here, we first examine the effect of sample and cohort size on the accuracy of dose selection in early … …Current Research in Biostatistics, Vol. 7, Issue 2 · 7 Apr 2018 · 7,980 accessesView PDFCite
Research ArticleOpen accessIn the abstractA GUI-Enabled, Automated LSTM-Based Inverse Kinematics Pipeline for 6-DOF Robotic Arms Using MATLAB and CoppeliaSimWaleed Abdulrahman Saleh Al-Akwa, Mohammed Abdulwahab Ahmed DabaExisting deep learning-based inverse kinematics (IK) solutions often target specific robotic arms and require significant modifications when applied to different configurations. To support early-phase design and testing of 6-degree-of-freedom (6-DOF) robotic arms, this study presents a fast and adaptable IK solution through a user-friendly interface. Unlike traditional numerical methods that are computationally intensive, sensitive to initial conditions, and may not … …Journal of Mechatronics and Robotics, Vol. 9, Issue 1 · 26 May 2025 · 8,252 accessesView PDFCite
Research ArticleOpen accessIn the abstractFuzzy Logic Controller for Static Synchronous Series Compensator with Energy Storage System for Transient Stability AnalysisSona Padma, M. RajaramProblem statement: FACTS devices play a major role in the efficient operation of the complex power system. FACTS devices such as STATCOM, SSSC and IPFC are in increasing usage. With energy storage systems they have a good control over the real as well as reactive power compensation and transient stability improvement. The design of controller for the SSSC with SMES … …Journal of Computer Science, Vol. 7, Issue 6 · 14 Jun 2011 · 6,694 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudy on the Key Success Factors of the Operation of a Regional Military Logistic Food Material CenterFu-Jin Wang, Chich-Jen Shieh, Chin-Jing LiProblem statement: In order to establish an integrated supply system of the military food material, the study was to discuss the key success factors of operation of the military regional food material logistic center in Taiwan. Approach: The Delphi method, questionnaires and telephone interviews were used to collect and integrate the opinions of experts and scholars. Simultaneously, the Analytic Hierarchy … …American Journal of Applied Sciences, Vol. 7, Issue 2 · 28 Feb 2010 · 7,137 accessesView PDFCite
Research ArticleOpen accessIn the abstractLow Power Phase Locked Loop Frequency Synthesizer for 2.4 GHz Band ZigbeeNesreen Mahmoud Hammam Ismail, Masuri OthmanProblem statement: Wireless communication systems are required for many applications. There are different standards for these systems. IEEE 802.15.4 defines the communication system standard for zigbee. This study discussed designing one of the blocks of zigbee transceiver which is the Phase Locked Loop (PLL). A major target for any communication systems is saving battery power, especially for zigbee as it … …American Journal of Engineering and Applied Sciences, Vol. 2, Issue 2 · 30 Jun 2009 · 8,057 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Framework for Design of Intelligent Simulation EnvironmentAli Azadeh, Farid GhaderiThis study describes a framework for design and development of intelligent simulation environment. The intelligent simulation environment prescribes an integrated rule-based approach to simulate and optimize a manufacturing system. An intelligent simulation model is a computer program capable of improving its performance by referring to production constraints, system's limitations and desired targets. It is a goal oriented, flexible and integrated … …Journal of Computer Science, Vol. 2, Issue 4 · 30 Apr 2006 · 6,702 accessesView PDFCite
Review ArticleOpen accessIn the abstractNikola TESLARelly Victoria Virgil Petrescu, Raffaella Aversa, Antonio Apicella et al.Nicolae Tesla, has remained and spent most of his life, making it hard to pronounce "Teslea"), is considered to be the inventor of the alternating current and uncovered cableless power transmission. It is attributed to the transmission of energy through monophase, biphasic, polyphase alternating currents and transmission of non-wired energy by electromagnetic waves (oscillations) in the industrial alternating current frequency … …American Journal of Engineering and Applied Sciences, Vol. 10, Issue 4 · 6 Nov 2017 · 13,193 accessesView PDFCite
Research ArticleOpen accessIn the abstractAn Analysis of Hybrid Tool Estimator: An Integration of Risk with Software EstimationJ. Frank Vijay, C. ManoharanProblem statement: One important problem with software development projects is to get an early and nevertheless accurate estimation of the effort needed to complete the project within the schedule. In the literature various methods have been developed for this purpose. The most popular examples are Boehm’s COCOMO, Albrecht’s Function Point Method or Sneed’s object-point method. The two last named methods … …Journal of Computer Science, Vol. 7, Issue 11 · 25 Aug 2011 · 6,752 accessesView PDFCite