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13 results for “Na+K+-ATPase”
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Research ArticleOpen accessEvery word in the titleOligoasthenoteratozoospermia and Necrozoospermia: A Study of Sperm Na+, K+-ATPase α4 and Plasma Membrane Ca2+-ATPase 4 RegulationSilvia W. Lestari, Dessy Noor Miati, AsmarinahThe oligoasthenoteratozoospermia (OAT) and necrozoospermia are the extreme sperm abnormalities in male infertility. These sperm abnormalities may be related to the imbalance of ion transport which mediated by the ion-transporting P-type ATPases, such as Na+, K+-ATPase and Ca2+-ATPase. Until now, there is limited data about the activity of Na+, K+-ATPase and Ca2+-ATPase in sperms in the OAT and necrozoospermia samples. … …OnLine Journal of Biological Sciences, Vol. 18, Issue 3 · 3 Aug 2018 · 11,269 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleQUERCETIN AMELIORATES DIABETIC NEPHROPATHY IN RATS VIA MODULATION OF RENAL NA+, K+-ATPASE EXPRESSION AND OXIDATIVE STRESSSalah O. Bashir, Mohamed Darwesh Morsy, Hussein F. Sakr et al.Diabetic Nephropathy (DN) is one of most prevalent complications of Diabetes Mellitus (DM), therefore prevention of its development is a important field for researches. Quercetin is a plant flavenoid with hypoglycemic and antioxidant properties that is claimed to have a reno-protective effect in diabetes. This study was designed to investigate the reno-preventive role of Quercetin treatment in terms of biochemical … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 14 Feb 2014 · 8,047 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleInvolvement of Microsomal Na+/K+ ATPase Activity in the Mechanism of Action of Dopaminergic D2 ReceptorsAbdulrahim Abu-JayyabProblem statement: Our previous research has shown that mitochondrial ATPase may have a role in the action of dopaminergic D2 receptors. It is therefore, thought of interest to investigate the effect of bromocriptine, sulpiride or their combination on the mitochondrial and microsomal ouabain sensitive and ouabain insensitive Na+/K+-ATPase in the liver of rats. Approach: In vivo treatment was carried out … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 6,971 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleNa,K-ATPase α Subunit-like Immunoreactive Proteins in Human Body FluidsJeng-Hsiung F. PengNa,K-ATPase was recently considered a target for breast cancer treatment since its potent inhibitors ouabain and related digitalis compounds that were reported circulating in body fluids before, were found to possess potent anti-breast cancer activity. Based on this finding, it is hypothesized that Na,K-ATPase derivatives could be circulating in the body and potential candidate biomarkers for early disease detection. Western … …American Journal of Immunology, Vol. 2, Issue 1 · 31 Mar 2006 · 6,892 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAroclor 1254 Toxicity to Mice Liver Membrane AtpasesShweta Pathak, Rahul KunduPresent communication reports the sub-acute dose and exposure duration dependent effects of Aroclor 1254 on total, Na+, K+, Ca++ and Mg++-ATPases of the mouse liver cells. The study tests two hypotheses, (a) whether the sublethal dose or the exposure duration dependent in vivo exposure of hydrophobic PCB (Aroclor 1254) affects the hydrophilic membrane-bound ion dependent ATPases of the liver cells … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 13 Jul 2013 · 6,791 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCadmium Induced Changes in Metabolic Function of Mitochondrial Isolated from Potato Tissue (Solanum tuberosum L.)Chagra Ali, Djebar Mohammed Réda, Rouabhi Rachid, Berrebbah HouriaProblem statement: Cadmium is highly toxic at low concentrations, but the mechanism of its toxicity is still not understood particularly at the cellular and subcellular level. Approach: In this study we examined the effects of cadmium on the oxidophosphorylation properties of mitochondria isolated from potatoes. Results: Cadmium strongly disturbed the respiratory metabolism of mitochondria isolated especially in the transfer of … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 1 · 31 Aug 2009 · 7,838 accessesView PDFCite
Research ArticleOpen accessIn the keywordsFour Dimensional (4-D) BioChemInfoPhysics Models of Cardiac Cellular and Sub-Cellular Vibrations (Oscillations)Kang Cheng, Chang-Hua ZouProblem statement: Cardiovascular Diseases (CVD) continued to be the leading cause of death. Failure or abnormal cardiac cellular or sub-cellular vibrations (oscillations) could lead failure or abnormal heart beats that could cause CVD. Understanding the mechanisms of the vibrations (oscillations) could help to prevent or to treat the diseases. Scientists have studied the mechanisms for more than 100 years. To … …OnLine Journal of Biological Sciences, Vol. 9, Issue 2 · 15 Jun 2009 · 7,057 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino RatsAjay k. Gupta, Neelam MisraHepatoprotective activity of aqueous ethanolic extract of Chamomile recutita capitula against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of aqueous ethanolic extract of Chamomile recutita capitula on blood and liver glutathione, Na+ K+- ATPase activity, serum marker enzymes, serum bilirubin, glycogen and thiobarbutiric acid reactive substances against paracetamol induced damage in rats … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 1 · 31 Mar 2006 · 18,946 accessesView PDFCite
EditorialOpen accessIn the abstractAre Heat Shock Proteins Druggable Candidates?Tawanda Zininga, Addmore ShonhaiBanumathy, G., V. Singh, S.R. Pavithra and U. Tatu, 2003. Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. J. Biol. Chem., 278: 18336-18345. DOI: 10.1074/jbc.M211309200 Brehmer, D., S. Rudiger, C.S. Gassler, D. Klostermeier and L. Packschies et al., 2001. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nature Structural Molecular … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 2 Dec 2014 · 8,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Glia Connection of the Glutamate/Glutamine ShuttleAngelina Rodriguez, Arturo OrtegaProblem statement: Glia cells outnumber neurons but their role in synaptic transmission is still matter of debate. The recycling of Glutamate, the main excitatory neurotransmitter, carried out by the glutamate/glutamine shuttle, requires the involvement of glia, suggesting their involvement in neurotransmission. Approach: This review focuses on novel functions of glia proteins involved in this cycle. Results: An activity-dependent interaction of … …Neuroscience International, Vol. 3, Issue 1 · 3 Sep 2012 · 7,770 accessesView PDFCite