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109 results for “Mutation”
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Research ArticleOpen accessEvery word in the titleIn silico Assessment of the Arg85Trp Glucokinase Mutation EffectsFaiza Bouldjennet, Souhila Bouaziz-Terrachet, Malha Azzouz, Rachida RaacheMaturity Onset Diabetes of the Young (MODY) is a heterogeneous group of autosomal dominantly inherited, young-onset β-cell disorders that account for approximately 2% of non-insulin-dependent diabetics in Europe. MODY2 or GCK-MODY is caused by inactivating heterozygous mutations in the glucokinase. Linkage of MODY to the Arg85Trp GCK mutation, among Algerian diabetic patients has been established in our previous research. The … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 6,808 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThrombophilic Genes Mutations in Women with Repeated In-Vitro Fertilization FailureNaglaa Fathy Al Husseini, Ahmad Y. Rezk, Mosad M. Odah et al.Problem statement: Thrombophilia has been recently implicated in early pregnancy loss and IVF implantation failure, by impairing the initial vascularization process occurring at implantation, which is necessary for a successful pregnancy. Approach: The aim of this study is to assess the presence possibility of mutation in thrombophilic genes [Factor V (FV) gene, Prothrombin (PT) gene and Methylenetetrahydrofolate Reductase (MTHFR) gene] … …Current Research in Medicine, Vol. 2, Issue 1 · 29 Mar 2011 · 7,662 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleChanges in Flower Development, Chlorophyll Mutation and Alteration in Plant Morphology of Curcuma alismatifolia by Gamma IrradiationThohirah Lee Abdullah, Johari Endan, B. Mohd NazirProblem statement: Curcuma alismatifolia Gagnep., commonly known as 'Thai tulip' or pathumma is a member of the family Zingiberaceae. This herbaceous perennial which can be grown from rhizomes have a great potential for use as a cut flower, flowering potted plant and as a garden plant for tropical landscaping. Unlike other bulbous floral crops, research on C. alismatifolia using gamma … …American Journal of Applied Sciences, Vol. 6, Issue 7 · 31 Jul 2009 · 8,437 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRisk of Second Non Breast Malignancies (SNBM) in Relation to Brca1 And Brca2 Mutation Status Following Breast-Conserving Surgery and RadiotherapyYoulia M. Kirova, Alain Fourquet, Alexia Savignoni, Brigitte Sigal-ZafraniWomen from hereditary breast cancer families with BRCA1/2 germline mutation are at increased risk for contralateral breast cancer (BC) and for ovarian cancer (OC). It is less clear whether mutation status influences the rate of SNBM other than OC. In addition, little is known on the risk of OC in individuals from hereditary BC families without identified BRCA mutation. Our … …American Journal of Immunology, Vol. 2, Issue 3 · 30 Sep 2006 · 7,228 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleTumor Suppressor P53 Gene Mutations Pattern Induced by Repeated Fried Palm Oil in RatsAbeer A.I. Hassanin, Abeer G.A. Hassan, Saadia A. Ali, Takao ItakuraThe present study aimed to examine the presence of p53 gene mutations in white albino rats fed on repeated fried palm oil. Eighteen sexually mature male Albino rats were used throughout the experiment. Rats were divided randomly into three groups, 6 animals each, namely; control group (CO) which orally administered by distilled water (NO) group which fed on basal diet … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 4 · 19 Dec 2014 · 7,696 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMutations in Tumor suppressor TP53 Gene in Formalin- Fixed, Paraffin Embedded Tissues of Squamous Cell Carcinoma (SCC) of Lung CancerAbbas Mohammadi, Ali Vaziri Gohar, Mohamad Reza ShakibaieThe TP53 gene mutations have been extensively studied in lung cancer and have been used as a means to understand the origin(s) and mechanisms of these mutations in lung cancer development. TP53 gene mutations occur frequently in many human cancers. Analysis of TP53 gene mutations can also provide clues to the etiology of tumor formation. Formalin-fixed, paraffin embedded (FFPE) tissues … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 1 · 31 Mar 2008 · 8,000 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSearching of Main Cause Leading to Severe Influenza A Virus Mutations and Consequently to Influenza Pandemics/EpidemicsGuang Wu, Shaomin YanThe unpredictable mutations in the proteins from influenza A virus lead to the great difficulty in prevention of possible outbreak of bird flu and pandemic/epidemic of influenza. This unpredictability is due to the fact that we know little about the causes that lead to the mutations. In three of our recent studies on the hemagglutinins from influenza A virus, we … …American Journal of Infectious Diseases, Vol. 1, Issue 2 · 30 Jun 2005 · 9,970 accessesView PDFCite
Literature ReviewOpen accessEvery word in the titlePotential Therapies for Mitochondrial Diseases Caused by mtDNA MutationsAnastasia V. Poznyak, Nikolay A. Orekhov, Dmitry Felixovich Beloyartsev et al.Mitochondrial diseases, caused by mutations in mitochondrial DNA (mtDNA), present significant genetic and clinical complexities that challenge accurate diagnosis and treatment. This review examines the critical molecular mechanisms underlying these disorders, particularly the role of heteroplasmy, where mixtures of mutated and normal mtDNA influence disease severity, and the nuclear-mitochondrial DNA interactions that compound diagnostic and therapeutic challenges. The threshold effect, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,735 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleGenetic Testing for Inherited Thrombophilia in Women with Recurrent Pregnancy Loss: Prevalence and Risk Assessment of Factor V Leiden, Prothrombin, and MTHFR MutationsLina M. Al Momani, Manal A. AbbasGenetic testing for inherited thrombophilia in women with recurrent pregnancy loss (RPL) may play an important role in detecting high-risk subjects. DNA was extracted from peripheral blood leukocytes. The high pure polymerase chain reaction template preparation kit and Reverse hybridization technique were used to detect the presence of factor V (G1691A, Leiden) (FVL), Factor II (prothrombin, G20210A), and 5,10-methylenetetrahydrofolate reductase … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 29 Nov 2025 · 2,559 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleNew Spring Wheat Mutation Resources with Improved Grain Quality, Metals Bioavailability and Yield ComponentsSaule Kenzhebayeva, Alfia Abekova, Guoping Zhang et al.Genetic variability in micronutrients is limited in wheat varieties. To broaden variation, seeds of cv. Eritrospermum-35 were irradiated with 100 and 200 Gy using 60Co, the treated seeds were grown to M7 generation with successive selection of the highest yield lines in each generation. Selected lines were evaluated for yield and grain quality traits such as iron, zinc and phytic … …American Journal of Agricultural and Biological Sciences, Vol. 12, Issue 4 · 2 Jan 2018 · 8,672 accessesView PDFCite