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14 articles for “Molecular Pathogenesis”
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Review ArticleOpen accessIn the keywordsDecoding Late Blight of Potato and Tomato: Insights into Pathogen Dynamics, Host Interactions and Emerging SolutionsHumayra Ferdus, Mahabuba Mostafa, Dodi Al Sharif, Md. Motaher HossainThe oomycete Phytophthora infestans is the source of late blight, a devastating disease that significantly impacts on tomato and potato cultivation worldwide, threatening food security and causing considerable economic losses. This review explores the epidemiological dynamics of late blight, focusing on the pathogen's life cycle, reproductive strategies, and molecular pathogenesis. Traditional management strategies, including cultural practices, host resistance, and biocontrol … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 5 Feb 2026 · 2,530 accessesView PDFCite
Research ArticleOpen accessIn the abstractIntegrated Analysis of Transcriptomic and Metabolomic Responses in Rice Resisting False SmutYanmin Yu, Haiying Liu, Hongtao Wu et al.Rice false smut, caused by Ustilaginoidea virens, is an important fungal disease that reduces both grain yield and quality. To dissect the molecular basis of resistance, we combined transcriptome sequencing and metabolite profiling in resistant and susceptible rice cultivars. Transcriptome sequencing revealed more than 8,500 genes with altered expression patterns after infection, while metabolite profiling detected over 700 significantly changed … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 27 Aug 2026 · 1,057 accessesView PDFCite
Research ArticleOpen accessIn the abstractVirtual Screening of Bioactive Compounds from the Onion (Allium) Genus as Potential Epidermal Growth Factor Receptor Inhibitors for MonkeypoxDinda Ratu Agustiani, Rakhmat Ramdhani Alwie, Harry NoviardiMonkeypox (Mpox) is an emerging zoonotic disease caused by the Mpox virus infection that affects humans and animals. Epidermal Growth Factor Receptor (EGFR) is an important target in the pathogenesis of Mpox. Epidermal Growth Factor (EGF), encoded by orthopoxviruses, plays an important role in intercellular transmission of the virus. Onion is known to have antiviral and immunomodulatory properties. Active compounds … …OnLine Journal of Biological Sciences, Vol. 26, Issue 3 · 6 Aug 2026 · 945 accessesView PDFCite
Review ArticleOpen accessIn the abstractOverview of Vascular Smooth Muscle Cells, Endothelial Cells, and Macrophages Apoptosis During Atherosclerosis DevelopmentAnastasia Vladimirovna Poznyak, Varvara Alexandrovna Orekhova, Vasily Nikolaevich Sukhorukov et al.Atherosclerosis is a complex disease that has garnered significant attention from researchers studying its various aspects. Its pathogenesis involves a wide array of cellular and molecular components, as well as crucial mechanisms and processes crucial for cellular and organismal functioning. Atherosclerosis is considered a chronic inflammatory disease characterized by disrupted lipid metabolism, oxidative stress, and immune response. Apoptosis, a fundamental … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 5 Jul 2024 · 4,675 accessesView PDFCite
EditorialOpen accessIn the abstractFocalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old DiseasesShuai Xing, Ping ZhouAll diseases have their Achilles’ Heel to target and this is especially true for immunorelated diseases which must be treated by targeting the immune system somewhere and somehow correctly. In the most recent decade, immunologists recognized that the Toll-Like Receptor (TLR) signaling pathway in innate immune system plays a double-edged role in the pathogenesis of many notorious diseases. Although the … …American Journal of Immunology, Vol. 13, Issue 3 · 6 Sep 2017 · 7,862 accessesView PDFCite
EditorialOpen accessIn the abstractChasing the Fat Demon: Fat Chance, Buddy?David L. Katz, Joachim Storsberg, Christian SchmidtScience is an interesting profession. At times, one could get caught up in his or her own world of thoughts, perception, far away from reality, sometimes referred to as the proverbial ivory tower (Lederberg, 1972). Science for the sake of science is, per se, not without merit, with our fragmented understanding of a given issue providing ample justification for experimentation … …American Journal of Immunology, Vol. 13, Issue 2 · 29 May 2017 · 8,134 accessesView PDFCite
EditorialOpen accessIn the abstractBig Data and Parkinson’s Disease - from Understanding of Disease to Personalised MedicineYen F. Tai, Nicola PaveseThe advancement of information technology in recent years has generated a huge amount of datasets in all areas of scientific research. This has led to new opportunities to harness the 'Big Data' to improve our understanding of diseases - from investigating disease mechanisms to monitoring treatment responses. The Big Data approach is a data-driven and often hypothesis-free, way of studying … …Neuroscience International, Vol. 7, Issue 1 · 27 Jul 2016 · 7,755 accessesView PDFCite
Review ArticleOpen accessIn the abstractRole of Cytokines and Transcription Factors in Periodontitis: A Review of Cellular and Molecular MechanismsAnne Carolina Eleutério Leite, Valéria Martins de Araújo Carneiro, Júlia Faria Nunes et al.Periodontal Diseases (PD) are characterized by pathological manifestation of host immune response to bacterial infection at the tooth/gingival interface. Evidences points periodontitis as a risk factor for pathological systemic conditions, such as, cardiovascular diseases and diabetes. The identification of host factors that determine their susceptibility to immune subversion can provide useful information in the pathogenesis of periodontitis. Protective acute inflammatory … …American Journal of Immunology, Vol. 11, Issue 4 · 9 Dec 2015 · 7,807 accessesView PDFCite
Research ArticleOpen accessIn the abstractGeneration of Anti-platelet Autoantibody During Dengue Virus InfectionKao-Jean Huang, Yee-Shin Lin, Hsiao-Sheng Liu et al.Dengue virus infection causes dengue fever, Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Thrombocytopenia is common in dengue fever and is always found in DHF/DSS. The pathogenesis of thrombocytopenia is poorly understood. To further understand the relationship between anti-dengue virus antibody and anti-platelet antibody, we generated monoclonal anti-dengue virus antibodies from the dengue virus infected mice that developed … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,535 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunopathogenesis of Dengue Hemorrhagic FeverHuan-Yao Lei, Kao-Jean Huang, Yee-Shin Lin et al.Dengue virus infection causes Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) whose pathogeneses were not clearly understood. A new hypothesis of immunopathogenesis is proposed for the development of the DHF/DSS. An aberrant immune over-activation after dengue virus infection not only impair the immune response to clear the virus, but also result in overproduction of cytokines … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 14,762 accessesView PDFCite