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284 results for “JAK”
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Review ArticleOpen accessEvery word in the titleJAK Inhibitors for Rheumatoid Arthritis: Assessing Efficacy and Safety in TreatmentAnastasia V. Poznyak, Varvara A Orekhova, Natalia Vladimirovna Elizova et al.Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, progressive joint destruction, and systemic complications. Dysregulated cytokine signaling through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway plays a central role in RA pathogenesis, making JAK inhibitors an important therapeutic option. Tofacitinib, baricitinib, and upadacitinib are oral targeted synthetic disease-modifying antirheumatic drugs that interfere with … …OnLine Journal of Biological Sciences, Vol. 26, Issue 4 · 8 Oct 2026 · 412 accessesView PDFCite
Case ReportOpen accessEvery word in the titleBrief Report: 20-Year Follow-Up of an Infant with Neurological Impairment Born to a Mother with Variant Creutzfeldt-Jakob DiseaseJustin Penner, Anjali Rampersad, James E. Burns et al.A term infant born via uncomplicated caesarian section was noted to be jittery, hypotonic, and have pooling of secretions at birth. Over the first four weeks of life, the infant developed four limb hypertonia, hyperreflexia, and clonus. MRI at 3.5 weeks old showed brain immaturity, poor myelination, and increased signal in the dorsal thalami. At six months, dystonic features with … …American Journal of Infectious Diseases, Vol. 21, Issue 1 · 7 Mar 2025 · 7,660 accessesView PDFCite
Case ReportOpen accessEvery word in the titleA Unique Presentation of Creutzfeldt-Jakob Disease in a Patient Consuming Deer Antler VelvetJoseph Wiedemer, Yanely Sanchez Ceja, An Cao, Ibrahim MustafaCreutzfeldt-Jakob Disease (CJD) is a rare rapidly progressive neurodegenerative prion disorder that is usually sporadic but may also be acquired from exposure to infected sources, classically via infections of bovine or human etiology. Cervid transmission of CJD is of particular concern in North America given the rapid spread of Chronic Wasting Disease (CWD)- the Cervid version of CJD. We present … …American Journal of Infectious Diseases, Vol. 17, Issue 1 · 18 Mar 2021 · 7,551 accessesView PDFCite
Research ArticleOpen accessEvery word in the titlePROBABLE CREUTZFELDT JAKOB DISEASE: CASE REPORTYanes Brum Bello, Alexandre Cossenza Pettezzoni De Almeida, Daniela Mendonca Sueth et al.Prion diseases are associated with the accumulation of an abnormal isoformof cellular prion protein (PrPSc), which is the principal constituent of prions. Prions replicate in lymphoreticular tissues before neuroinvasion, suggesting that lymphoreticular biopsy samples may allow early diagnosis by detection of PrPSc. Creutzfeldt-Jakob Disease (CJD) is the most frequent prion disease in humans. Clinical diagnosis of sporadic (CJD) is based … …Current Research in Medicine, Vol. 5, Issue 1 · 14 Mar 2014 · 8,133 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEscherichia Coli and Biophysicochemical Relationships of Seawater and Water Pollution Index in the Jakarta BayEndan Suwandana, Kensuke Kawamura, Kazuhiko Tanaka et al.Problem statement: Relationships between Escherichia coli (E. coli) and biophysicochemical properties of seawater at different seasons and water pollution index were investigated in the Jakarta Bay, Indonesia. Approach: Water quality data taken at different seasons (Early Rainy Season (ERS) in November 2007 and Late Dry Season (LDS) in August 2008) were analyzed. Additionally, to compare pollution level at different seasons, … …American Journal of Environmental Sciences, Vol. 7, Issue 3 · 9 Jul 2011 · 7,992 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDesign of Enterprise Architecture Using Zachman Framework at Private School in Center JakartaKeysia Aprilia, Francka Sakti Lee, Yemima Monica Geasela et al.Technology is currently fundamental and necessary, including in the education sector, where information technology, such as enterprise architecture, can be applied to support and facilitate school business processes. Private schools in Central Jakarta are one of the schools that utilize information technology in running their business. However, currently, schools still need to use information technology optimally, so it is necessary … …Journal of Computer Science, Vol. 20, Issue 9 · 8 Jul 2024 · 6,359 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSpatial Analysis of Accessibility for Public Transportation, A Case Study in Jakarta, Bus Rapid Transit System (Transjakarta), IndonesiaApri Zulmi Hardi, AbdulKader Ali MuradIntegrating public transportation has become a prevalent aspect of urban expansion in developed and developing countries. There are numerous benefits associated with implementing public transportation systems within urban areas, which may serve as a viable solution to address various traffic-related issues. Nevertheless, certain nations that have adopted public transportation encounter accessibility issues affecting the efficiency of such services. The authors … …Journal of Computer Science, Vol. 19, Issue 10 · 31 Aug 2023 · 8,096 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleTransTrip: A Shortest Path Finding Application for Jakarta Public Transportation using Dijkstra AlgorithmRini Wongso, Cin Cin, Suhartono, JosephGovernment of Jakarta, the capital of Indonesia, highlighted congestion as one of the issues that must be addressed immediately. The high population of Jakarta increases the number of vehicles operating on the streets and causes congestion that leads to a loss of 67.5 trillion rupiah. The development of adequate public transport facilities is expected to be one of the solution, … …Journal of Computer Science, Vol. 14, Issue 7 · 29 Jun 2018 · 9,328 accessesView PDFCite
InvestigationOpen accessEvery word in the titleThermal Comfort Investigation in Three Hot-Humid Climate Theme Parks in JakartaM. Donny Koerniawan, Weijun GaoThis research presents the results of a study about thermal comfort measurement and evaluation in the theme parks. Physiological Equivalent Temperature (PET) is employed as a thermal index in this research. This research studied how climate impacts thermal comfort in the three biggest theme parks in Jakarta: Taman Mini Indonesia Indah (TMII), Kebun Binatang Ragunan (KBR) and Taman Impian Jaya … …American Journal of Environmental Sciences, Vol. 11, Issue 3 · 17 Aug 2015 · 8,110 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleReview of Photochemical Smog Pollution in Jakarta Metropolitan, IndonesiaDollaris R. Suhadi, M. Awang, M. N. Hassan et al.An analysis of photochemical smog pollution in Jakarta was attempted using data from the existing air quality monitoring stations. Ground-level ozone potential is high in Jakarta due to the high traffic emissions of ozone precursors and the favorable surface meteorological conditions. Despite the frequent missing data during the 1996-1999 monitoring, which resulted in lower ozone values, ozone episodes were significantly … …American Journal of Environmental Sciences, Vol. 1, Issue 2 · 30 Jun 2005 · 7,247 accessesView PDFCite