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14 results for “Genetic Structures”
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Research ArticleOpen accessIn the keywordsOptimal Arrangement of Energy-Dissipating Members for Seismic Retrofitting of Truss StructuresToru Takeuchi, Yusuke Kinouchi, Ryota Matsui, Toshiyuki OgawaAlthough passive response control design is a popular method, an arrangement methodology for energy-dissipating devices in spatial structures has not been established yet. In this study, optimization techniques are applied to arrangements of energy-dissipating devices in truss tower structures. First, a response prediction rule using the response spectrum and the equivalent linearization method is proposed. Then, a genetic algorithm is … …American Journal of Engineering and Applied Sciences, Vol. 8, Issue 4 · 14 Jul 2015 · 7,619 accessesView PDFCite
InvestigationOpen accessIn the keywordsDevelopment of Genetic Constructions for Exctocytosis ControlIrina Nikolaevna Dominova, Vitaly Anvarovich Kasymov, Ekaterina Vladimirovna Silina et al.A fragment of the research project devoted to the development of genetic control of exocytosis is presented in the work, which can further ensure the success of targeted therapy of various diseases, including neurodegenerative ones. For the purpose of specific transfection of intracellular cascades in astrocytes in vivo, we have developed an experimental sample of the reagent kit. The latter … …OnLine Journal of Biological Sciences, Vol. 18, Issue 2 · 29 Jan 2018 · 7,310 accessesView PDFCite
Research ArticleOpen accessIn the abstractConservation of Binding of Llama and Other Animals’ Hemoglobins to Haptoglobins Across SpeciesMoges Woldemeskel, Oluseyi A. VanderpuyeThe plasma protein haptoglobin binds hemoglobin released from lysed erythrocytes. It causes removal of the free hemoglobin, thus preventing pathological oxidation of cells. Hemoglobin higher level structures are well conserved across animal species but primary structures can be as little as 50% homologous. Because of these differences, the question arose as to what extent hemoglobins can bind to haptoglobins from … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 1 · 26 Jan 2018 · 9,200 accessesView PDFCite
Research ArticleOpen accessIn the abstractIntegrating a Repairing-based Genetic Algorithm-Neighborhood Search Structure in Solving the Course Timetabling ProblemChong-Keat Teoh, Habibollah Haron, Antoni Wibowo, Mohd. Salihin NgadimanThe course timetabling problem is not a trivial task as it is an NP-hard and NP-complete problem and many solutions have been proposed due to its high complexity search landscape. In essence, the nature of the course timetabling problem is to assign a lecturer-course entity to existing teaching venue and timeslot in an academic institution. In this article, the authors … …Journal of Computer Science, Vol. 12, Issue 10 · 15 Dec 2016 · 7,102 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn silico Analysis of three Committed-Steps Involved in Triterpenoid Biosynthesis from Ganoderma lucidumXiaorong Shui, Xiaozhong Lan, Wei LeiGanoderma lucidum is widely considered as one of the most valuable Traditional Chinese Medicines, with various bioactive constituents and pharmaceutical effects. Triterpenoids are important effective ingredients of G. lucidum, which are synthesized mainly through the mevalonate pathway. In this study, we aimed to characterize and analyze three committed-step enzymes of the mevalonate pathway, 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (HMGR), Farnesyl Diphosphate Synthase … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 3 · 15 Aug 2016 · 7,347 accessesView PDFCite
Research ArticleOpen accessIn the abstractPerformance of Hybrid GANN in Comparison with Other Standalone Models on Dengue Outbreak PredictionNor Azura Husin, Norwati Mustapha, Md. Nasir Sulaiman et al.Early prediction of diseases especially dengue fever in the case of Malaysia, is very crucial to enable health authorities to develop response strategies and context preventive intervention programs such as awareness campaigns for the high risk population before an outbreak occurs. Some of the deficiencies in dengue epidemiology are insufficient awareness on the parameter as well as the combination among … …Journal of Computer Science, Vol. 12, Issue 6 · 2 Jul 2016 · 8,162 accessesView PDFCite
Research ArticleOpen accessIn the abstractMulti-Objective Evolutionary Optimization of Sandwich Structures: An Evaluation by Elitist Non-dominated Sorting Evolution StrategyIlyani Akmar, A.B, O. Kramer, T. RabczukIn this study, an application of evolutionary multi-objective optimization algorithms on the optimization of sandwich structures is presented. The solution strategy is known as Elitist Non-Dominated Sorting Evolution Strategy (ENSES) wherein Evolution Strategies (ES) as Evolutionary Algorithm (EA) in the elitist Non-dominated Sorting Genetic algorithm (NSGA-II) procedure. Evolutionary algorithm seems a compatible approach to resolve multi-objective optimization problems because it … …American Journal of Engineering and Applied Sciences, Vol. 8, Issue 1 · 22 Apr 2015 · 7,323 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Analysis of UGT1A9 Genetic Polymorphisms between Chinese Han and Tibetan PopulationsWei Yan, Jian Cui, Yuewen Wang et al.Although various polymorphisms have been identified in the UGT1A9 gene in the main sorts of ethnic groups in the world, no investigations have been focused on the Chinese Tibetan populations and the comparison between Chinese Tibetan and Han populations to date. This study was designed to systematically compare genetic differences between the two populations. We investigated the functional regions of … …Current Research in Medicine, Vol. 3, Issue 2 · 23 Aug 2012 · 7,641 accessesView PDFCite
Research ArticleOpen accessIn the abstractVoltage-Gated Channels as Causative Agents for EpilepsiesMutasem Abuhamed, Xiao Bo, Kun Xia et al.Problem statement: Epilepsy is a common neurological disorder that afflicts 1-2% of the general population worldwide. It encompasses a variety of disorders with seizures. Approach: Idiopathic epilepsies were defined as a heterogeneous group of seizure disorders that show no underlying cause .Voltage-gated ion channels defect were recognized etiology of epilepsy in the central nervous system. The aim of this article … …American Journal of Immunology, Vol. 4, Issue 4 · 31 Dec 2008 · 6,959 accessesView PDFCite
Research ArticleOpen accessIn the abstractRapamycin Inhibits Cystogenesis by Cystic Epithelial Cells Derived from Human Autosomal Dominant Polycystic KidneysGerard Elberg, Teresa V. Lewis, Lijuan Chen, Martin A. TurmanAutosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders and carries a high health burden since it progresses to renal failure in half of the afflicted individuals by the 6th decade of life. Currently, there is no effective treatment to slow the progression of ADPKD. Rapamycin, a drug most commonly used as an immunosuppressive agent … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 7,101 accessesView PDFCite