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14 articles for “GCM”
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EditorialOpen accessEvery word in the titleGc Protein-Derived Macrophage Activating Factor (GcMAF) and Autism: Do Clinical Results Require a Novel Interpretation?Marco RuggieroIn this Editorial I reinterpret the results observed with the Gc protein-derived Macrophage Activating Factor (GcMAF) at the light of two recent papers published on this topic. According to the results and the hypothesis emerging from these papers, the biological and clinical effects thus far attributed to GcMAF are indeed to be ascribed to a glycosaminoglycan, chondroitin sulfate, that binds … …American Journal of Immunology, Vol. 12, Issue 4 · 14 Oct 2016 · 10,339 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleTherapeutic Effects of Highly Purified De-Glycosylated Gcmaf in the Immunotherapy of Patients with Chronic DiseasesLynda Thyer, Emma Ward, Rodney Smith et al.The de-Glycosylated vitamin D binding protein is a powerful Macrophage Activating Factor (GcMAF) that shows multiple biological effects that could be exploited in the immunotherapy of tumours, viral infections and autism. Here we report the observation of a series of clinical cases describing the results obtained administering highly purified GcMAF to patients with diverse types of chronic diseases. These are … …American Journal of Immunology, Vol. 9, Issue 3 · 20 Aug 2013 · 11,858 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCLIMATE CHANGE IMPACT ASSESSMENT ON WATERSHED HYDROLOGY: A COMPARISON OF THREE APPROACHESSomsubhra Chattopadhyay, Manoj K. JhaSeveral methods of impact assessment have been developed over the years which basically incorporate future climate projections of atmospheric-ocean circulation based climate models into the simulation of land surface hydrological processes. This study attempted to evaluate three methods of climate change impact assessment: (a) Frequency perturbation method, (b) direct method and (c) delta change method. A well-calibrated hydrologic model, Soil … …American Journal of Engineering and Applied Sciences, Vol. 7, Issue 1 · 27 Mar 2014 · 8,597 accessesView PDFCite
Research ArticleOpen accessIn the keywordsGenetic Analysis of Bifidobacteriaceae in a Fermented Milk and Colostrum Product in Relation to Immune FunctionMarco RuggieroThis study investigates the microbial composition of a commercially available Swiss fermented milk and colostrum product with a history of use in chronic condition management since 2014. The analysis, performed using the Axiom Microbiome Array, identified a high number of targets corresponding to microbial species classified as probiotics belonging to the Bifidobacteriaceae family. The array provided 28 unique targets, each … …American Journal of Immunology, Vol. 19, Issue 1 · 2 Aug 2024 · 9,049 accessesView PDFCite
Case ReportOpen accessIn the keywordsConsumption of an Extremely Biodiverse Probiotic and a Supplement based on Microbial Chondroitin Sulfate is Associated with Very Low Serum Alpha-N-acetylgalactosaminidase (Nagalase) Activity and Decrease of C-reactive Protein ValuesMichael Carter, Stefania Pacini, Marco RuggieroWe describe the case of a 57-years-old male healthy professional who added to his nutritional plan a novel, extremely biodiverse, probiotic and a supplement based on microbial chondroitin sulfate, vitamin D3 and ultrapure phosphatidylcholine to improve his healthy life expectancy. After three months of such a nutritional regimen, serum alpha-N-acetylgalactosaminidase (nagalase) activity was 0.40 that is a value below the … …American Journal of Immunology, Vol. 16, Issue 1 · 22 Apr 2020 · 13,049 accessesView PDFCite
EditorialOpen accessIn the keywordsIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCLINICAL EXPERIENCE OF CANCER IMMUNOTHERAPY INTEGRATED WITH OLEIC ACID COMPLEXED WITH DE-GLYCOSYLATED VITAMIN D BINDING PROTEINEmma Ward, Rodney Smith, Jacopo J.V. Branca et al.Proteins highly represented in milk such as α-lactalbumin and lactoferrin bind Oleic Acid (OA) to form complexes with selective anti-tumor activity. A protein present in milk, colostrum and blood, vitamin D binding protein is the precursor of a potent Macrophage Activating Factor (GcMAF) and in analogy with other OA-protein complexes, we proposed that OA-GcMAF could demonstrate a greater immunotherapeutic activity … …American Journal of Immunology, Vol. 10, Issue 1 · 8 Mar 2014 · 13,186 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEffects of Gc-Macrophage Activating Factor in Human Neurons; Implications for Treatment of Chronic Fatigue SyndromeRodney Smith, Lynda Thyer, Emma Ward et al.Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease of multifactorial aetiology characterized by immune system dysfunction, widespread inflammation, multisystemic neuropathology and persistent pain. Given the central role of the immune system in the pathogenesis of the syndrome, we studied the effects of a potent modulator of the immune system in in vitro and in vivo models that could help … …American Journal of Immunology, Vol. 9, Issue 4 · 6 Nov 2013 · 10,982 accessesView PDFCite
Case ReportOpen accessIn the keywordsClinical Case Report of a Novel Immunotherapeutic Approach to Autism Spectrum Disorders based on an emulsion of Chondroitin Sulfate, Vitamin D3 and Oleic AcidNicola Antonucci, Stefania Pacini, Marco RuggieroIn this clinical case report we describe the effects associated with the administration of a supplement constituted by chondroitin sulfate, vitamin D3 and oleic acid (Rerum®) on the symptoms of Autism Spectrum Disorders (ASD). 44 patients (11 females and 33 males) were administered this supplement for a period of two months and variations of symptomatology were evaluated by the Clinical … …American Journal of Immunology, Vol. 13, Issue 3 · 10 Aug 2017 · 19,224 accessesView PDFCite
Research ArticleOpen accessIn the abstractSynthesis and Charaterization of Magnesium Zinc Ferrites as Electromagnetic SourceNoorhana Yahya, Ami Salwani Mohamad Nor Aripin, Azizuddin A. Aziz et al.Fabrication of Mg1-XZnXFe2O4 (where x = 0.2, 0.3, 0.4 and 0.5) samples using a conventional technique is reported. Oxides of magnesium, zinc and iron with purity of about 99.99% were mixed with distilled water in a milling machine for 12 hours. They were then filtered and presintered at 1250°C and sintered at 1350°C for 10 h in air. The phase … …American Journal of Engineering and Applied Sciences, Vol. 1, Issue 1 · 31 Mar 2008 · 8,998 accessesView PDFCite