97 results for “Dose Dependent”

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Research ArticleOpen accessEvery word in the titleAntioxidant Properties and Dose-Dependent Effects of Monkey Fruits (Artocarpus lakoocha) against Paracetamol-Induced Hepato-Renal Toxicity in RatsMd. Yousuf Ali, Md. Reaz Morshed, Md. Sakib Hossen et al.In this study, the antioxidant potentials and protective effect of ethanolic extract of monkey fruits (Artocarpus lakoocha) (AL) was investigated against paracetamol-induced toxicity in rats. AL which contains high concentration of polyphenols, flavonoids, tannins and protein, exhibited high radical scavenging activity and ferric reducing antioxidant power. Administration of paracetamol (500 mg/kg) for seven consecutive days caused severe oxidative stress in … …American Journal of Pharmacology and Toxicology, Vol. 13, Issue 1 · 26 Nov 2018 · 8,337 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleDose-Dependent Neurotoxic Effects of Monosodium Glutamate and its Potential Genetic Transmission in MiceYanan Zou, Qiong Liang, Lu Liu et al.This study aimed to preliminarily investigated the neurotoxic effects of monosodium glutamate on mice and their pups, and the potential possibility of a genetic mechanism influencing the pups. In this study, mice were given different doses of Monosodium Glutamate (MSG) at doses of 2.0 or 4.0 g/kg body weight for 10 continuous days, and its impacts on both the mice … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 14 Nov 2025 · 3,031 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleVitamin D Supplements Tone Down the Progression of Atheromatous Plaque Formation in a Dose-Dependent MannerAhmed Farouk, Khalid M. Mohany, Magdy Algowhary et al.Hypovitaminosis D has a negative impact on the cardiovascular system. We performed the current study to investigate the expression of Vitamin D Receptor (VDR) in atherosclerotic human male aortas and to examine the effect of different doses of Vit. D supplementation on VDR expression in the aortas of male rats fed a High-Fat Diet (HFD). Human participants included 50 atherosclerotic … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 3 · 5 Oct 2021 · 6,724 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsEvaluation of Acute Oral Toxicity Induced by Tablets Based on Ethanolic Extract of Salvia dumetorum Leaves in Experimental RatsYana Levaya, Karakoz Badekova, Mussa Zholdasbayev, Gayane AtazhanovaThe aim of this study was to assess the acute oral toxicity of a solid dosage form based on Salvia dumetorum Andrz. ex Besser leaf extract (SDT5) in experimental rats. Acute toxicity was evaluated over a 14-day observation period following a single oral administration at three dose levels (500 mg/kg, 1000 mg/kg, and 2000 mg/kg), prepared in 0.5 mL of … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 23 Jun 2026 · 1,241 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEffects of Dietary Emamectin Benzoate at Recommended and Overdose Levels on the Pathophysiological Responses and Tolerability of Oreochromis niloticus at Fry StageJasmine Singha, Thangapalam Jawahar Abraham, Satyen Kumar Panda, Prasanna Kumar PatilEmamectin Benzoate (EB) has been recommended as a feed additive for the control of fish ectoparasites. This investigation examined the impact of dietary EB on physiological responses, antioxidant defence mechanisms, and histopathological changes in key organs, and on the kinetics of residue deposition and elimination in the muscle of Oreochromis niloticus fry. Fry were administered EB feeds at 50 µg … …American Journal of Pharmacology and Toxicology, Vol. 20, Issue 1 · 1 Jul 2026 · 1,469 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCytotoxicity Evaluation of Curcumin-FITC Conjugates in Granulosa Cells Isolated from Ovarian Follicles of Kampung Chicken (Gallus gallus domesticus)Sukarman Hadi Jaya Putra, Mansur S, UmarudinLinking curcumin to fluorescein isothiocyanate (FITC) results in a hybrid fluorescent marker (curcumin-FITC) that exhibits improved stability and sensitivity in detection. This study sought to evaluate the biological safety and cytotoxic effects of curcumin-FITC on granulosa cells obtained from ovarian follicles (2-5 mm, F1-F4 stage) of Kampung chickens. Following fluorescent labeling with different concentrations of curcumin-FITC (0-100 μg/mL), cell viability … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 14 May 2026 · 1,497 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe interplay between Cadmium and Zinc Induced Developmental Perturbations and Apoptosis in Daphnia MagnaNaima Hamid, Siti Nur Airina Binti Ibrahim et al.Assessing combined toxicity provides a realistic and comprehensive approach to determining toxicological effects in aquatic species under environmentally relevant conditions. This study was conducted to understand the effects of single and combined metal mixtures on freshwater flea and Daphnia magna. Environmentally Relevant Concentrations (ERCs) of Cadmium (Cd) and Zinc (Zn) at a low dose (10μg/L) and high dose (30 μg/L) … …American Journal of Environmental Sciences, Vol. 21, Issue 1 · 11 Jun 2025 · 6,015 accessesView PDF Cite

Research ArticleOpen accessIn the abstractMolluscicidal Activity of Ethanolic Dieffenbachia seguine (Dumb Cane) Leaf Extract Against Pomacea canaliculata (Golden Apple Snail)Alfredo V. Corpuz, Carmela M. Florentino, Ace Danielle C. Avero, Sherwin V. AlvaroThe golden apple snail (Pomacea canaliculata), an invasive species that originated in South America, has caused significant damage to rice plantations in Southeast Asia, notably the Philippines. Because of its voracious appetite for aquatic vegetation and quick reproduction rate, it poses a significant agricultural problem. Conventional control approaches, which mostly use chemical molluscicides, have increased environmental issues and threats to … …OnLine Journal of Biological Sciences, Vol. 26, Issue 3 · 14 Sep 2026 · 846 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIn-vitro Larvicidal Potentials of Achillea Extracts on Strongylid LarvaeLyudmila Lider, Yerlan Suleimen, Gulnur Mamytbekova et al.Strongylid infections remain among the most widespread and clinically significant helminthoses in horses, with increasing concerns regarding anthelmintic resistance. Against this background, we investigated the in-vitro larvicidal activity of Achillea salicifolia and Achillea setacea extracts against strongylid larvae. We evaluated concentrations of 20, 30, and 40% at exposure times of 0.5, 1, 2, and 4 h (n = 3). Larval … …American Journal of Animal and Veterinary Sciences, Vol. 21, Issue 2 · 21 Jul 2026 · 1,032 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAccumulation and Effect of Manganese on Chloroplasts and Antioxidant Responses in Arabidopsis ThalianaJun Xing, Xue Yang, Cailing YuanIn this study, 5-day-old seedlings of Arabidopsis thaliana were exposed to 0, 0.5, and 1.0 mmol/L MnCl₂ for 6 days by using three independent biological replicates. The results indicated that Mn content in roots exhibited a dose-dependent increase with rising external Mn supply. The elevated Mn levels led to significant reductions in the nutrient content of K, Ca, Na, and … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 18 Jul 2026 · 824 accessesView PDF Cite