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4 articles for “DNA Repair Genes”
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Research ArticleOpen accessEvery word in the titleCpG Oligodeoxynucleotides Debate the Damaging Action of Cisplatin on Immune Cell DNA: A PCR Array Application on Repair Genes ExpressionNaglaa Fathy Alhusseini, Amal Abo El-Fadl, Shabaan Hemada et al.Synthetic Oligodeoxynucleotides (ODN) expressing CpG motifs (CpG-ODN) mimic the immunostimulatory activity of bacterial DNA and are commonly used to activate Toll Like Receptor 9 (TLR9) for therapeutic applications. CpG-ODN can counteract the activity of DNA-damaging chemotherapy and radiation therapy on immune cell and enhance immunity in preclinical mouse models. We hypothesized that these actions of CpG-ODN on immune cells are … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 3 · 27 Jul 2016 · 7,625 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Research ArticleOpen accessIn the abstractExperimental Evidence for the Role of Natural Radioactivity in Influencing Viability of Commensal MicroorganismsMarco RuggieroTo investigate the feasibility of culturing edible microbes, classified as probiotics for human consumption, in commercially available, naturally radioactive, mineral water; to compare their viability with that of the same microbes cultured in deuterium-depleted water. A diversified array of probiotics was cultured in two different naturally radioactive mineral waters, or in deuterium-depleted water in order to assess the effects of … …American Journal of Immunology, Vol. 17, Issue 1 · 26 May 2021 · 8,741 accessesView PDFCite
Research ArticleOpen accessIn the abstractColor Doppler Evaluation of Isovolumetric Relaxation Time and of Signals Arising from Axons of the Median Nerve as a Means to Evaluate Mitochondrial Functionality in the Context of Immunotherapy of Cancer and Chronic Conditions Associated with Mitochondrial DysfunctionStefania Pacini, Marco RuggieroReactive Oxygen Species (ROS) arising from the disruption of mitochondrial respiration act as endogenous mutagens and tumor promoters. When production of ROS exceeds the capacity of DNA repair mechanisms, random mutations and aneuploidy ensue, thousands of genes become unbalanced and genetic/epigenetic chain reactions lead to progressive aneuploidy with only two outcomes: karyotypes so altered that are not viable or karyotypes … …American Journal of Immunology, Vol. 15, Issue 1 · 12 Oct 2019 · 9,690 accessesView PDFCite