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291 results for “DNA”
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Research ArticleOpen accessEvery word in the titleNerve Growth Factor (NGF) Gene Analysis in Menstrual Blood of Endometriosis: DNA Methylation and mRNA Expression LevelsOcktariyana, Nurul Hikmawati et al.Menstrual blood flow is reversed through the fallopian tubes during the menstrual process and implants outside the uterus, which is the theory of pathogenesis in endometriosis sufferers. This study aims to analyze the level of DNA methylation and mRNA expression of the Nerve Growth Factor (NGF) gene in menstrual blood in endometriosis patients and analyze the correlation. The study was … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 7 Aug 2025 · 4,684 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAssociations of HSD17B1 Gene Expression with its DNA Methylation and Estradiol Level in Polycystic Ovary Syndrome Indonesian PatientsRina Puspita, Andon Hestiantoro et al.PCOS's origin and mechanism are still unknown. Epigenetics has been linked to PCOS in an increasing number of studies in recent years. The most extensively researched epigenetic alteration is DNA methylation. During organismal development, DNA methylation can control gene expression by altering transcription factor binding. The alterations in DNA methylation are directly associated with follicular development in PCOS. Studies show … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 8 Jan 2024 · 5,399 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleOrlistat Induce Renal Toxicity, DNA Damage, and Apoptosis in Normal and Obese Female RatsHaneen Mushtaq Hameed, Ahmed Flayyih Hasan, Zainab Haytham Razooki et al.Obesity has been linked to several chronic diseases, including fatty liver disease, fatty heart disease, diabetes mellitus, hypertension, obstructive sleep apnea, and cancer. The purpose of the current study was to determine how Orlistat affected renal toxicity, DNA damage, and apoptosis that were brought on by obesity in normal and obese female rats. There were four groups made up of … …OnLine Journal of Biological Sciences, Vol. 23, Issue 1 · 18 Jan 2023 · 5,831 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDNA Yields and PCR Amplification Success Using Degraded Animal CorpsesJimmy Ilunga, Paul Michael, Grace Daniel et al.A recurring problem with ancient specimens from wildlife animals is that their preserved tissues contain small amounts of DNA in a degraded state. The specific objectives of the present study were: (1) To determine DNA yields from different animal tissues; (2) to compare traditional (manual) DNA extraction protocols with commercial procedures and (3) to assess the success of PCR amplification … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 12 Feb 2020 · 7,479 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAge-Dependent Variation of Telomere Length and DNA Damage in ChickenMaxim S. Makarenko, Alexander V. Usatov, Lyubov V. Getmantseva et al.Birds are unique models for molecular studies on aging processes and cellular senescence because of their slow rates of aging and comparatively long life spans among homoeothermic animals. The study aimed to examine the relative telomere length and amount of nuclear, mitochondrial DNA lesions in hens of different ages and to find out the correlation between these biomarkers of aging. … …OnLine Journal of Biological Sciences, Vol. 17, Issue 4 · 14 Dec 2017 · 7,505 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSperm DNA Fragmentation and Apoptosis Levels: A Comparison of the Swim up and the Density Gradient Centrifugation Methods for Sperm PreparationSilvia W. Lestari, Triyana Sari, Dwi A. PujiantoThis study investigated the efficiency of two sperm preparation methods, namely, density gradient centrifugation and the swim-up method, in selecting spermatozoa based on the DNA fragmentation index and the apoptosis levels. Fifteen semen samples from infertile couples underwent sperm preparation in this study. The Makler® counting chamber and Eosin Y staining were used to analyse the sperm concentration, motility and … …OnLine Journal of Biological Sciences, Vol. 16, Issue 4 · 14 Nov 2016 · 7,419 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCpG Oligodeoxynucleotides Debate the Damaging Action of Cisplatin on Immune Cell DNA: A PCR Array Application on Repair Genes ExpressionNaglaa Fathy Alhusseini, Amal Abo El-Fadl, Shabaan Hemada et al.Synthetic Oligodeoxynucleotides (ODN) expressing CpG motifs (CpG-ODN) mimic the immunostimulatory activity of bacterial DNA and are commonly used to activate Toll Like Receptor 9 (TLR9) for therapeutic applications. CpG-ODN can counteract the activity of DNA-damaging chemotherapy and radiation therapy on immune cell and enhance immunity in preclinical mouse models. We hypothesized that these actions of CpG-ODN on immune cells are … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 3 · 27 Jul 2016 · 7,625 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleDNA Vaccination Associated with Eliminating Inheritance Risks during Embryo Development: A ReviewRia MargianaThe process of immunization using modified DNA is essential whenever scientists desire to trigger an artificial response in the host’s body to improve immunity. The use of DNA vaccines awakens the somatic cells of the host to produce antigens that will assist the body to prepare to fight infections through preventive measures triggered by the vaccines. These biological inventions have … …OnLine Journal of Biological Sciences, Vol. 16, Issue 2 · 26 May 2016 · 6,873 accessesView PDFCite
HypothesisOpen accessEvery word in the titleExtending the Repertoire of Structures in DNA NanotechnologyClive DelmonteDNA nanotechnology remains an active area of research and advances have been reviewed recently. DNA nanotechnology seeks to deploy molecules at an atomic level and on a small molecule scale. Other techniques in biophysics and biochemistry do not need to address the issue of the true structure of the nucleic acids at an atomic level but, rather, at a macro-atomic … …Current Research in Nanotechnology, Vol. 6, Issue 1 · 7 Oct 2015 · 13,914 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleHypermethylation and Hypomethylation of DNA: Implication for Diagnosis and Prognosis of Prostate CancerLubos Danisovic, Stanislav ZiaranProstate cancer belongs to the most common cancers and it is the second leading cause of cancer death in men. A genetic predisposition with epigenetic changes in DNA contributes to the development of the disease. DNA hypermethylation and hypomethylation belong to the most studied epigenetic changes in prostate cancer development. Both forms may lead to chromosomal instability and transcriptional gene … …OnLine Journal of Biological Sciences, Vol. 15, Issue 2 · 13 Jun 2015 · 6,528 accessesView PDFCite