Hypermethylation and Hypomethylation of DNA: Implication for Diagnosis and Prognosis of Prostate Cancer
Lubos Danisovic1 & Stanislav Ziaran2 Show affiliations
- University of the Comenius, Slovakia
- Comenius University, Slovakia
OnLine Journal of Biological Sciences, Volume 15, Issue 2, pp. 83–88 · doi.org/10.3844/ojbsci.2015.83.88
Abstract
Prostate cancer belongs to the most common cancers and it is the second leading cause of cancer death in men. A genetic predisposition with epigenetic changes in DNA contributes to the development of the disease. DNA hypermethylation and hypomethylation belong to the most studied epigenetic changes in prostate cancer development. Both forms may lead to chromosomal instability and transcriptional gene silencing. This article is aimed at brief review of information in respect to DNA hypermethylation and hypomethylation in the prostate cancer development. Moreover, we discuss their implication for diagnosis and prognosis of prostate cancer.
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Danisovic, L. & Ziaran, S. (2015). Hypermethylation and Hypomethylation of DNA: Implication for Diagnosis and Prognosis of Prostate Cancer. OnLine Journal of Biological Sciences, 15(2), 83–88. https://doi.org/10.3844/ojbsci.2015.83.88
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