12 results for “Cephalosporin C”

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Research ArticleOpen accessEvery word in the titleThe Effect of a 4th Generation-Cephalosporin Introduction upon the Incidence of Multidrug-Resistant Gram-Negative Bacteria in a Non-Teaching HospitalGuilherme Henrique Campos Furtado, Luciana Baria Perdiz, Eduardo Alexandrino Servolo MedeirosProblem statement: Antimicrobial resistance is a worrisome situation in hospitals around the world and the misuse of certain classes of antimicrobials has contributed for this situation. Approach: We performed a prospective surveillance study on the incidence of multi-drug resistant bacteria before (phase 1) and after (phase 2) the introduction of a 4th-generation cephalosporin in a non-teaching hospital. Results: There was … …American Journal of Infectious Diseases, Vol. 4, Issue 4 · 31 Dec 2008 · 6,876 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleResistance to Third-Generation Cephalosporins and Other Antibiotics by Enterobacteriaceae in Western NigeriaA. O. Okesola, O. MakanjuolaProblem statement: The emergence and spread of resistance to third-generation cephalosporins are threatening to create species resistant to all currently available agents. The most common cause of bacterial resistance to beta-lactam antibiotics is the production of beta-lactamases and many of the 2nd and 3rd-generation penicillins and cephalosporins were specifically designed to resist the hydrolytic action of major β-lactamases. However new … …American Journal of Infectious Diseases, Vol. 5, Issue 1 · 31 Mar 2009 · 8,007 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsProbing the Substrate Specificity and Intersubunit Interactions of Brevundimonas Diminuta Glutaryl Acylase with Site-Directed MutagenesisMichael Eldarov, Anna Lyashenko, Tatyana Sherbakova et al.Glutaryl-7-ACA acylases (GLA) are industrial enzymes widely used for the production of 7-aminocepahlosporanic acid (7-ACA)-the starting compound for manufacturing of semisynthetic cephalosporin antibiotics. Generation of mutant GLA's with increased activity and stability, capability for single-step conversion of cephalosporin C (CPC) directly to 7-ACA is a promising route to improve the current biocatalytic technologies. In this study GLA from Brevundimonas diminuta … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 12 Nov 2014 · 8,160 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsAntibiotic Usage in Intensive Care Units of Tabriz Imam Reza Hospital, 2011Sepehr Taghizadeh, Mehdi Haghdoost, Omid Mashrabi, Zahra ZeynalikhasraghiDrug therapy is one of the most important factors in providing community health. In a proper selection of an antibiotic for curing an infection, the kind of infective agent and its sensitivity to the utilized drugs must be regarded. The patients whom are admitted in ICUs are 5 to 7 folds more vulnerable to infection. The studies has been done … …American Journal of Infectious Diseases, Vol. 9, Issue 4 · 22 Nov 2013 · 7,715 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAnaerobic Fermentation for Ceftriaxone Sodium Degradation in Excess Sludge: pH-Dependent Performance, Metabolite Formation, and Microbial Community DynamicsWeiwei Li, Hong Niu, Yonghui Zhang et al.The accumulation of ceftriaxone sodium (CTX), a third-generation cephalosporin antibiotic, in wastewater and sludge poses significant environmental and health risks, necessitating effective degradation strategies. This study investigated anaerobic fermentation of excess sludge (12,000-14,000 mg/L) spiked with 15 mg/L CTX under varying pH conditions (4, 7, 10, 12) to evaluate sludge reduction, metabolite formation, and microbial community dynamics. Results demonstrated that … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 31 Jul 2026 · 857 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDominant Multidrug-Resistant Bacteria in Five Biggest Hospitals in Asir Region from March to June 2018Mohammed AlmaghrabiThere is a rapid increase in the emergence of multidrug resistance which consider as one of the public health threats in all over the world. MDR was defined as acquired non-susceptibility to at least one agent in three or more antimicrobial categories. The present study aims to determine the dominant multi-drug resistant bacteria in the five biggest hospitals in Asir … …American Journal of Infectious Diseases, Vol. 17, Issue 1 · 9 Mar 2021 · 6,782 accessesView PDF Cite

Research ArticleOpen accessIn the abstractStandard Versus Specific Therapy for Chronic Osteomyelitis TreatmentAngela Ingianni, Giorgio Lampis, Samuela Laconi et al.58 patients with chronic osteomyelitis were treated either with a standard therapy or with a specific targeted therapy based on the antibiogram assay. Standard therapy was performed by a 15-day course of a parenteral cephalosporin (usually ceftriaxone) in combination with an aminoglycoside (e.g. netilmicin), followed by oral therapy with a fluoroquinolone (generally ciprofloxacin) for 1 to 3 months; specific therapy … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 6,874 accessesView PDF Cite

Research ArticleOpen accessIn the abstractBacterial Resistance in Primary Bloodstream Infections in the COVID-19 Pandemic: What has Changed at a Reference Hospital in Northeastern Brazil?Jonathan Da Silva Xavier, Jorge Luiz Nobre Rodrigues, Caroline Mary Gurgel Dias Florêncio et al.The increased use of central venous catheters due to the severity of COVID-19 cases and the difficulty in implementing preventive Healthcare-Associated Infection measures contributed to worsening an already challenging scenario of bacterial resistance. Characterizing the impact of these significant health crises on the bacterial resistance profile is necessary to strengthen antimicrobial control protocols in an effort to decrease morbidity. Our … …American Journal of Infectious Diseases, Vol. 20, Issue 2 · 4 Sep 2024 · 5,033 accessesView PDF Cite

Research ArticleOpen accessIn the abstractExtended-Spectrum β-Lactamases Producing Escherichia coli Strains Monitored Over 4 Years in The University Hospital in Košice, SlovakiaViera Lovayová, Lucia Vargová, Mária Nagyová et al.The beta-lactamases with extended spectrum of activity (ESBL) are medically one of the most important group of enzymes. The presented study provides identification and determination of the spectrum of resistance against different and clinically used antimicrobial drugs in the clinical isolates of Escherichia coli. These isolates had their origin in different departments of the University Hospital L. Pasteur in Košice. … …Current Research in Microbiology, Vol. 7, Issue 1 · 16 Jun 2016 · 14,537 accessesView PDF Cite

Research ArticleOpen accessIn the abstractSusceptibility and Detection of Extended Spectrum β-Lactamase Enzymes from Otitis Media PathogensEjikeugwu Chika, Iroha Ifeanyichukwu, Adikwu Michael, Esimone CharlesOtitis media is the bacterial infection of the middle ear usually accompanied with inflammation, effusions and pain. It can present clinically in two major forms: Acute Otitis Media (AOM) and Otitis Media with Effusion (OME) and it is one of the leading cause of hospital visits and antibiotic prescriptions amongst children and even adults. Antibiotic resistance is a global public … …American Journal of Infectious Diseases, Vol. 9, Issue 1 · 21 Mar 2013 · 7,970 accessesView PDF Cite